A5035590428- Cardiac, Anesthesia and Surgical Outcomes
- Parkinson's Disease Mechanisms and Treatments
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Acute Kidney Injury Research
- Genetic Neurodegenerative Diseases
- Surgical site infection prevention
- Multiple Sclerosis Research Studies
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Epilepsy research and treatment
- Botulinum Toxin and Related Neurological Disorders
- Smoking Behavior and Cessation
- Mitochondrial Function and Pathology
- HIV-related health complications and treatments
- Restless Legs Syndrome Research
- Reconstructive Surgery and Microvascular Techniques
- Appendicitis Diagnosis and Management
- Rheumatoid Arthritis Research and Therapies
- Ion Transport and Channel Regulation
- Anorectal Disease Treatments and Outcomes
- Urological Disorders and Treatments
- Prion Diseases and Protein Misfolding
- Nuclear Receptors and Signaling
- Pain Management and Opioid Use
- Neurological and metabolic disorders
National Hospital for Neurology and Neurosurgery
2022-2024
University College London
2022-2024
Queen Mary University of London
2024
Queen's Hospital
2022
University Hospitals Bristol NHS Foundation Trust
2019
University of Birmingham
2016
Queen Elizabeth Hospital Birmingham
2016
University Hospitals Birmingham NHS Foundation Trust
2016
Imperial College London
2014
Introduction While magnetic resonance imaging (MRI) is established in diagnosing and monitoring disease activity multiple sclerosis (MS), its utility predicting progression less clear.
Background HIV has changed from a rapidly deteriorating illness to complex chronic disease, with increasing incidences of comorbidity, including cancer, and liver, lung cardiovascular diseases. North West London 6719 individuals living the human immunodeficiency virus (HIV), 873 whom reside in Borough Brent. Traditionally, commissioning services have focused on therapy alone without considering how comorbidity affects treatment outcome total service costs. Setting The setting for study was...
Abstract Background Accurate assessment of surgical-site infection (SSI) is crucial for surveillance and research. Self-reporting patient measures are needed because current SSI tools limited assessing patients after leaving hospital. The Bluebelle Wound Healing Questionnaire (WHQ) was developed or observer completion; this study tested its acceptability, scale structure, reliability validity in with closed primary wounds abdominal surgery. Methods Patients completed the WHQ...
Among people with Parkinson's disease (PD), non-motor symptoms (NMS) are a well-recognised cause of significant morbidity and poor quality life. Yet, it is only more recently that NMS have been recognised to affect the lives patients atypical parkinsonian syndromes in similar fashion. The aim this article highlight compare relative prevalence among published literature, which largely remain underreported unaddressed routine clinical practice. All occur PD also found commonly syndromes. In...
Background In multiple sclerosis (MS), both lesion accrual and brain atrophy predict clinical outcomes. However, it is unclear whether these prognostic features are equally relevant throughout the course of MS. Among 103 participants recruited following a clinically isolated syndrome (CIS) followed up over 30 years, we explored (1) white matter lesions were prognostically more earlier later in disease towards development secondary progressive (SP) disease; (2) if so, when balance...
Nonneurogenic chronic urinary retention is an uncommon problem in young female individuals, and a well characterised causes Fowler syndrome (primary disorder of urethral sphincter relaxation). Intermittent catheterisation often challenging, gold standard treatment sacral neuromodulation not widely available. Urethral botulinum toxin injection has been shown to be effective cross-sectionally, however little known about long-term outcomes.
Surgical site infection (SSI) affects up to 20% of people with a primary closed wound after surgery. Wound dressings may reduce SSI. To assess the feasibility multicentre randomised controlled trial (RCT) evaluate effectiveness and cost-effectiveness dressing types or no SSI in surgical wounds. Phase A - semistructured interviews, outcome measure development, practice survey, literature reviews value-of-information analysis. B pilot RCT qualitative research questionnaire validation. Patients...
Urethral sphincter botulinum toxin injections is an alternative treatment for urinary retention in women with Fowler's syndrome and when access to health services were curtailed during the Covid19 pandemic, we continued offer prevent increased demand on catheter due a recurrence of retention. We describe our experience delivering safe timely this period lockdowns restricted healthcare. retrospectively reviewed records all treated transperineal urethral injection between 23rd March 2020 31st...
Atraumatic splenic rupture is a rare surgical emergency that often attributed to neoplastic or infectious causes. Rarely, it has been identified also occur in the setting of an acute severe sepsis and cases pelvic abscess formation post-appendicectomy. However, our knowledge, co-presentation appendiceal not previously described. We present case 67-year old male with decompensating haemorrhagic shock secondary atraumatic on background inadequately treated complicated appendicitis originally...
A previously well and independent 84-year-old man presented with subacute behavioural disturbance cognitive decline, progressing over one month to a bedbound encephalopathic state myoclonus. Examination at that time revealed global dysfunction, dysarthria, dysphasia, myoclonus motor pyramidal signs. MRI study widespread high signal on T2-weighted imaging in the hemi- spheric deep white matter, as right caudate nucleus. EEG frequent periodic triphasic complexes. CSF examination was positive...
Background Fowler’s Syndrome typically presents as chronic urinary retention in young women, charac- terised by poor urethral sphincter relaxation. Standard treatment sacral neuromodulation is invasive and may not necessarily be appropriate for all patients. Aims To evaluate efficacy safety of botulinum toxin injections into the women with syndrome Results 17 (mean age 36.9±12.4 years) diagnosed (abnormal EMG and/or elevated pressure profile) unsuitable received 100U injected EMG-guided...