A5102771938- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Prostate Cancer Diagnosis and Treatment
- Delphi Technique in Research
- Meta-analysis and systematic reviews
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Health Systems, Economic Evaluations, Quality of Life
- Clinical practice guidelines implementation
- Urological Disorders and Treatments
- Colorectal Cancer Screening and Detection
- Urinary Tract Infections Management
- Statistical Methods in Clinical Trials
- Gastric Cancer Management and Outcomes
- Medical and Biological Sciences
- Connective tissue disorders research
- Cancer Risks and Factors
- Hormonal and reproductive studies
- Body Contouring and Surgery
- Humor Studies and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Identity, Memory, and Therapy
- Mental Health via Writing
- Dialysis and Renal Disease Management
- Nausea and vomiting management
University of Bristol
2010-2020
At Bristol
2020
NIHR Bristol Biomedical Research Centre
2017
Southmead Hospital
2004-2011
New England Research (United States)
2007
New England Research Institutes
2007
Velindre NHS Trust
2004
University of Oxford
2004
Medical Research Council
2002
Newcastle University
2001
Methods for developing a core outcome or information set require involvement of key stakeholders to prioritise many items and achieve agreement as the set. The Delphi technique requires participants rate importance in sequential questionnaires (or rounds) with feedback provided each subsequent round such that are able consider views others. This study examines impact receiving from different stakeholder groups, on rating level between stakeholders. Randomized controlled trials were nested...
Objective To investigate the effect of hormone replacement therapy on post‐menopausal urinary stress incontinence. Design Double‐blind, placebo‐controlled, randomised trial. Setting University associated teaching hospital. Population Post‐menopausal women with genuine incontinence, not taking therapy. Methods Randomisation to six months oestradiol valerate 2 mg daily or placebo. Assessment prior treatment and upon study completion SF‐36 health status questionnaire, Bristol Female Lower...
<h3>Abstract</h3> <b>Objective:</b> To examine the impact on sexual function of treatments for lower urinary tract symptoms in men. <b>Design:</b> Multicentre pragmatic randomised controlled trial standard surgery (transurethral resection prostate), non-contact laser therapy, and conservative management (no active intervention). <b>Setting:</b> Three clinical centres United Kingdom. <b>Participants:</b> 340 men aged between 48 90 years with related to benign prostatic enlargement. <b>Main...
Abstract Background Accurate assessment of surgical-site infection (SSI) is crucial for surveillance and research. Self-reporting patient measures are needed because current SSI tools limited assessing patients after leaving hospital. The Bluebelle Wound Healing Questionnaire (WHQ) was developed or observer completion; this study tested its acceptability, scale structure, reliability validity in with closed primary wounds abdominal surgery. Methods Patients completed the WHQ...
Resource use measurement by patient recall is characterized inconsistent methods and a lack of validation. A validated standardized resource measure could increase data quality, improve comparability between studies, reduce research burden.To identify minimum set core items that should be included in adult instrument for UK health economic evaluation from provider perspective.Health economists with experience UK-based evaluations were recruited to participate an electronic Delphi survey....
A comprehensive evaluation of bariatric surgery is required to inform decision-making. This will include measures benefit and risk. It possible that stakeholders involved with value these outcomes differently, although this has not previously been explored. study aimed investigate compare how professionals patients prioritise surgery.Systematic reviews qualitative interviews created an exhaustive list outcomes. informed the development a 130-item questionnaire, structured in four sections...
No AccessJournal of UrologyCLINICAL UROLOGY: Original Articles1 Jul 2000A RANDOMIZED TRIAL COMPARING TRANSURETHRAL RESECTION OF THE PROSTATE, LASER THERAPY AND CONSERVATIVE TREATMENT MEN WITH SYMPTOMS ASSOCIATED BENIGN PROSTATIC ENLARGEMENT: CLasP STUDY JENNY L. DONOVAN, TIM J. PETERS, DAVID E. NEAL, SARA T. BROOKES, SANDEEP GUJRAL, K. NINAN CHACKO, MARK WRIGHT, GAIL KENNEDY, and PAUL ABRAMS DONOVANJENNY DONOVAN , PETERSTIM PETERS NEALDAVID NEAL BROOKESSARA BROOKES GUJRALSANDEEP GUJRAL...
We explored the association of lower urinary tract symptoms and erectile dysfunction in a racially ethnically diverse random sample men.The Boston Area Community Health Survey used stratified, 2-stage cluster to recruit 2,301 men representative Boston. Data were obtained on suggestive number urogynecologic conditions, comorbidities, lifestyle psychosocial factors.The percent reporting moderate/severe symptoms, as measured by American Urological Association symptom index, ranged from 8% those...
<h3>Importance</h3> Acute lower respiratory tract infection is common and often treated inappropriately in primary care with antibiotics. Corticosteroids are increasingly used but without sufficient evidence. <h3>Objective</h3> To assess the effects of oral corticosteroids for acute adults asthma. <h3>Design, Setting, Participants</h3> Multicenter, placebo-controlled, randomized trial (July 2013 to final follow-up October 2014) conducted 54 family practices England among 401 cough at least 1...
Health economics analysis plans (HEAPs) currently lack consistency, with uncertainty surrounding appropriate content. We aimed to develop a list of essential items that should be included in HEAPs for economic evaluations conducted alongside randomized trials.
<h3>BACKGROUND/AIMS</h3> Primary open angle glaucoma patients and suspects make up a considerable proportion of outpatient ophthalmological attendances require lifelong review. Community optometrists can be suitably trained for assessment glaucoma. This randomised controlled trial aims to assess the ability community in monitoring this group patients. <h3>METHODS</h3> Measures cup disc ratio, visual field score, intraocular pressure were taken by optometrists, hospital eye service research...
BackgroundTransurethral resection of the prostate (TURP) is standard operation for benign prostatic obstruction. Thulium laser transurethral vaporesection (ThuVARP) a technique with suggested advantages over TURP, including reduced complications and hospital stay. We aimed to investigate TURP versus ThuVARP in men lower urinary tract symptoms or retention secondary obstruction.MethodsIn this randomised, blinded, parallel-group, pragmatic equivalence trial, seven UK hospitals bothersome...
We assessed the effectiveness of laser therapy versus transurethral prostatic resection in men with symptomatic chronic urinary retention secondary to benign enlargement.This trial was multicenter, pragmatic and randomized. Analysis done by intent treat. Laser involved neodymium:YAG noncontact visual prostate ablation, while performed standard electroresection. Patients were included our study if they reported moderate severe lower tract symptoms an International Prostate Symptom Score...
The optimal treatment for localised oesophageal squamous cell carcinoma (SCC) is uncertain. We assessed the feasibility of an RCT comparing neoadjuvant and surgery with definitive chemoradiotherapy. A in three centres examined incident patients reasons ineligibility using multi-disciplinary team meeting records. Eligible were offered participation integrated qualitative research involving audio-recorded recruitment appointments interviews to inform training staff. Of 375 SCC, 42 (11.2%)...
Core outcome set (COS) developers increasingly employ Delphi surveys to elicit stakeholders' opinions of which outcomes measure and report in trials a particular condition or intervention. Research outside COS development demonstrates that question order can affect response rates lead 'context effects', where prior questions determine an item's meaning influence responses. This study examined the impact within survey for oesophageal cancer surgery.
For the majority of patients with osteoarthritis (OA), joint replacement is a successful intervention for relieving chronic pain. However, between 10-30% continue to experience pain after replacement. Evidence suggests that risk factor severity acute post-operative The aim this randomised controlled trial (RCT) determine if intra-operative local anaesthethic wound infiltration additional standard anaethesia regimen can reduce at 12-months total knee (TKR) and hip (THR) OA. 300 TKR THR are...
Abstract Background Five-year survival after hepatic resection for colorectal cancer (CRC) liver metastases is good, but data on patient-reported outcomes are lacking. This study describes the long-term impact of surgery CRC outcomes. Methods The used European Organization Research and Treatment Cancer (EORTC) Quality Life Questionnaire (QLQ) C30 disease-specific module, EORTC QLQ-LMC21. For functional scales, mean scores out 100 with 95 per cent c.i. were calculated; differences 10 points...
Joint hypermobility syndrome (JHS) is a heritable disorder associated with laxity and pain in multiple joints. Physiotherapy the mainstay of treatment, but there little research investigating its clinical effectiveness.To develop comprehensive physiotherapy intervention for adults JHS; to pilot intervention; conduct randomised controlled trial (RCT) determine feasibility conducting future definitive RCT.Patients' health professionals' perspectives on JHS were explored focus groups (stage 1)....
In previous randomised clinical trials of thromboprophylaxis after total hip replacement, low-molecular-weight heparin has been given for an arbitrary 7 to 14 days. The risk factors are mainly perioperative and it is possible that a shorter course may be adequate. We assessed the safety effectiveness three-day course. 156 primary THR patients randomisation either control group or receive enoxaparin at 12 hours preoperatively 36 postoperatively. Thrombosis was diagnosed by routine venography....