A5039346718- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Helicobacter pylori-related gastroenterology studies
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Gastroesophageal reflux and treatments
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Eosinophilic Esophagitis
- Cardiac, Anesthesia and Surgical Outcomes
- Dysphagia Assessment and Management
- Transplantation: Methods and Outcomes
- Gastrointestinal disorders and treatments
- Lung Cancer Treatments and Mutations
- Enhanced Recovery After Surgery
- Foreign Body Medical Cases
- Nutrition and Health in Aging
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Pancreatic function and diabetes
- Clinical Nutrition and Gastroenterology
- Organ Transplantation Techniques and Outcomes
- Diabetes and associated disorders
- Neuroendocrine Tumor Research Advances
Newcastle University
2003-2025
Fera Science (United Kingdom)
2025
Royal Victoria Infirmary
2013-2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2012-2021
Newcastle upon Tyne Hospital
1994-2021
Royal College of Surgeons of Edinburgh
2020-2021
Queen Mary University of London
2021
St. James's Hospital
2020
Queen Elizabeth Hospital Birmingham
2020
Trinity College Dublin
2020
In Brief Introduction: Perioperative complications influence long- and short-term outcomes after esophagectomy. The absence of a standardized system for defining recording quality measures esophageal resection has meant that there is wide variation in evaluating their impact on these outcomes. Methods: Esophageal Complications Consensus Group comprised 21 high-volume surgeons from 14 countries, supported by all the major thoracic upper gastrointestinal professional societies. Delphi surveys...
Utilizing a standardized dataset with specific definitions to prospectively collect international data provide benchmark for complications and outcomes associated esophagectomy.Outcome reporting in oncologic surgery has suffered from the lack of system operative results particularly complications. This is case esophagectomy affecting accuracy relevance outcome assessments, clinical trial results, quality improvement projects.The Esophageal Complications Consensus Group (ECCG) involving 24...
Application of evidence-based perioperative care protocols reduces complication rates, accelerates recovery and shortens hospital stay. Presently, there are no comprehensive guidelines for gastrectomy.An international working group within the Enhanced Recovery After Surgery (ERAS®) Society assembled an framework optimal patients undergoing gastrectomy. Data were retrieved from standard databases personal archives. Evidence recommendations classified according to Grading Recommendations,...
In Brief Objective: Surveillance, Epidemiology and End Results (SEER) data indicate that number of lymph nodes removed impacts survival in gastric cancer. Our aim was to study this relationship esophageal Methods: The population included 2303 cancer patients (1381 adenocarcinoma, 922 squamous) from 9 international centers had R0 esophagectomy prior 2002 were followed at regular intervals for 5 years or until death. Patients treated with neoadjuvant adjuvant therapy excluded. Results:...
Objective The authors determined if more radical surgery with extended lymphadenectomy improves the results of gastrectomy in patients adenocarcinoma gastric antrum. Summary Background Data overall survival cancer is disappointing. Improved has been reported by Japanese authors. Whether this because a higher number early cancers series, different biologic behavior Asians, or adoption remains unclear. Methods R1 subtotal omentectomy and R3 total (omentectomy, splenectomy, distal...
In Brief Objective: The aim of this study was to determine whether the risk systemic disease after esophagectomy can be predicted by number involved lymph nodes. Summary Background Data: Primary is curative in some but not all patients with esophageal cancer. Identification at high for would allow selective use additional therapy. This a multinational, retrospective review treated resection alone assess impact nodes on probability disease. Methods: population included 1053 cancer (700...
Background Barrett's esophagus (BE) is a commonly undiagnosed condition that predisposes to esophageal adenocarcinoma. Routine endoscopic screening for BE not recommended because of the burden this would impose on health care system. The objective study was determine whether novel approach using minimally invasive cell sampling device, Cytosponge, coupled with immunohistochemical staining biomarker Trefoil Factor 3 (TFF3), could be used identify patients who warrant endoscopy diagnose BE....
BackgroundPeri-operative chemotherapy and surgery is a standard of care for patients with resectable oesophagogastric adenocarcinoma. Bevacizumab, monoclonal antibody against VEGF, improves the proportion responding to treatment in advanced gastric cancer. We aimed assess safety efficacy adding bevacizumab peri-operative gastric, junction, or lower oesophageal adenocarcinoma.MethodsIn this multicentre, randomised, open-label phase 2–3 trial, we recruited aged 18 years older histologically...
BackgroundNeoadjuvant chemotherapy before surgery improves survival compared with alone for patients oesophageal cancer. The OE05 trial assessed whether increasing the duration and intensity of neoadjuvant further improved current standard regimen.MethodsOE05 was an open-label, phase 3, randomised clinical trial. Patients surgically resectable adenocarcinoma classified as stage cT1N1, cT2N1, cT3N0/N1, or cT4N0/N1 were recruited from 72 UK hospitals. Eligibility criteria included WHO...
These guidelines have been prepared by the British Society of Gastroenterology.They represent a
BACKGROUND: Bile duct strictures may be benign or malignant. A definite diagnosis is desirable to advise patients of their prognosis and identify any amenable curative surgery. AIMS: To compare different methods cytology sampling from biliary evaluate the use in this context. PATIENTS AND METHODS: In a prospective study 54 undergoing endoscopic retrograde cholangiopancreatography (ERCP) had samples obtained as follows: (1) stricture brushings, (2) screw thread "Soehendra stent retriever"...
Despite increasingly radical surgery for oesophageal cancer, many patients continue to develop recurrent disease. The aim of this study was evaluate the pattern failure following attempted curative oesophagectomy with two-field lymphadenectomy adenocarcinoma and squamous cell carcinoma middle lower third oesophagus.A total 176 consecutive discharged from hospital R0 resection between 1 April 1990 31 December 1999 were followed evidence recurrence over a mean interval 26 months.Adenocarcinoma...
Neoadjuvant therapy is increasingly the standard of care in management locally advanced adenocarcinoma oesophagus and junction (AEG). In randomised controlled trials (RCTs), MAGIC regimen pre- postoperative chemotherapy, CROSS preoperative chemotherapy combined with radiation, were superior to surgery only RCTs that included AEG but not powered on this cohort. No completed RCT has directly compared neoadjuvant or perioperative chemoradiation. The Neo-AEGIS trial, uniquely AEG, including...
Abstract Background Oesophagogastric cancer surgery is immunosuppressive. This may be modulated by omega-3 fatty acids (O-3FAs). The aim of this study was to assess the effect perioperative O-3FAs on clinical outcome and immune function after oesophagogastric surgery. Methods Patients undergoing subtotal oesophagectomy total gastrectomy were recruited allocated randomly an O-3FA enteral immunoenhancing diet (IED) or standard nutrition (SEN) for 7 days before surgery, postoperative...
To address uncertainty of whether clinical stage groupings (cTNM) for esophageal cancer share prognostic implications with pathologic after esophagectomy alone (pTNM), we report data-simple descriptions patient characteristics, categories, and non-risk-adjusted survival-for clinically staged patients from the Worldwide Esophageal Cancer Collaboration (WECC). Thirty-three institutions six continents submitted data using variables standard definitions: demographics, comorbidities, all-cause...
The information surgeons impart to patients and want about surgery for cancer is important but rarely examined. This study explored provided by patient preferences in consultations which oesophageal was discussed. Pre-operation oesophagectomy discussed were studied three United Kingdom hospitals subsequently interviewed. Consultations interviews audio-recorded, transcribed full anonymized. Interviews elicited views the patients’ information. Thematic analysis of consultation-interview pairs...
An important parameter for survival in patients with esophageal carcinoma is lymph node status. The distribution of metastases depends on tumor characteristics such as location, histology, invasion depth, and neoadjuvant treatment. exact unknown. Neoadjuvant treatment surgical strategy the pattern nodal but consensus extent lymphadenectomy has not been reached. aim this study to determine resectable or gastro-esophageal junction whom a transthoracic esophagectomy 2- 3-field performed. This...
The aim of this study was to evaluate the diagnosis, management and outcome mediastinal leaks following radical oesophagectomy with a stapled intrathoracic anastomosis.Some 291 consecutive patients underwent two-phase subtotal gastric interposition for malignancy. Patients clinical suspicion leak were investigated contrast radiology flexible upper gastrointestinal endoscopy.Nineteen (6.5 per cent) developed proven at median 8 (range 3-30) days surgery. Contrast endoscopy identified that 13...