A5029560991- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Hepatitis C virus research
- Genetic factors in colorectal cancer
- Hepatitis B Virus Studies
- Glioma Diagnosis and Treatment
- Esophageal and GI Pathology
- Eosinophilic Esophagitis
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Pediatric Hepatobiliary Diseases and Treatments
- Wnt/β-catenin signaling in development and cancer
- Brain Metastases and Treatment
- Metabolism and Genetic Disorders
- Ovarian cancer diagnosis and treatment
- Inflammatory mediators and NSAID effects
- S100 Proteins and Annexins
- Liver physiology and pathology
- Cancer, Hypoxia, and Metabolism
- Gastroesophageal reflux and treatments
- CAR-T cell therapy research
BC Cancer Agency
2024
Oregon Health & Science University
2024
Leicester Royal Infirmary
2004-2022
The University of Texas MD Anderson Cancer Center
2018-2021
University Hospitals of Leicester NHS Trust
2005-2020
Royal Manchester Children's Hospital
2018
Manchester Academic Health Science Centre
2018
Genomics (United Kingdom)
2017
University of Birmingham
1989-2016
University of Edinburgh
2016
Oesophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's oesophagus biggest risk factor. We aimed to evaluate efficacy high-dose esomeprazole proton-pump inhibitor (PPI) aspirin for improving outcomes in patients with oesophagus.
Cirrhosis with liver failure due to hepatitis C virus (HCV) infection is the most common indication for transplantation (LT). Reinfection of transplanted by HCV inevitable, and aggressive accelerated progression graft cirrhosis may be observed. Of concern, recent reports suggest that outcome LT have deteriorated in years. Determinants rate immunocompetent non-transplant patient are well defined, powerful determinant age at time infection. Following HCV, recipient does not affect reinfection....
Intestinal metaplasia (IM) and dysplasia in Barrett's esophagus are recognized surrogates for esophageal adenocarcinoma risk. While few would argue with the "hunt dysplasia," there is a divide regarding usefulness of histological confirmation intestinal endoscopically apparent long segment esophagus. We aimed to assess frequency 125 consecutive patients columnar-lined determine optimal biopsy protocol detect metaplasia.Two-hundred ninety-six endoscopies were performed over 4-yr period...
Current models of clonal expansion in human Barrett's oesophagus are based upon heterogenous, flow-purified biopsy analysis taken at multiple segment levels. Detection identical mutation fingerprints from these samples led to the proposal that a mutated clone with selective advantage can clonally expand fill an entire expense competing clones (selective sweep fixation model). We aimed assess clonality much higher resolution by microdissecting and genetically analysing individual crypts. The...
Barrett's esophagus (BE) increases the risk of esophageal adenocarcinoma (EAC). We found to be BE has been associated with single nucleotide polymorphisms (SNPs) on chromosome 6p21 (within HLA region) and 16q23, where closest protein-coding gene is FOXF1. Subsequently, Esophageal Adenocarcinoma Consortium (BEACON) identified loci for near CRTC1 BARX1, within 100 kb FOXP1. aimed identify further SNPs that increased validate previously reported associations.
Fibroobliterative lesions and fibrous cholangitis are characteristic histological of primary sclerosing cholangitis. To determine whether such can be found in the liver allograft, they represent recurrent disease, we reviewed all consecutive material taken at greater than 6 mo after transplantation a 3-yr period from series 207 transplantations (22 with cholangitis, 185 controls without cholangitis). Because patients have biliary system reconstructed by means Roux loop, compared findings...
Abstract Purpose: At presentation, most cases of adenocarcinoma the esophagus (ACE) are inoperable. Although chemotherapy can prolong survival, patients eventually die as a result refractory disease. Epidermal growth factor receptor (EGFR) is almost universally expressed in ACE and negative prognostic factor. Experimental Design: This open-label, two-center, noncomparative, two-part phase II trial assessed EGFR tyrosine kinase inhibitor gefitinib (500 mg/d) with advanced, inoperable ACE. The...
OBJECTIVES To assess the variation in practice of Barrett's esophagus (BE) management comparison with accepted international guidelines before and after introduction a large BE randomized controlled trial (RCT) protocols including those tissue sampling. DESIGN A validated anonymized questionnaire was sent to 401 senior attending gastroenterologists asking for details their current BE, especially histological Of 228 respondents, 57 individuals (each from different center) were first group...
<h3>Objective</h3> Barrett9s oesophagus shows appearances described as 'intestinal metaplasia', in structures called 'crypts' but do not typically display crypt architecture. Here, we investigate their relationship to gastric glands. <h3>Methods</h3> Cell proliferation and migration within glands was assessed by Ki67 iododeoxyuridine (IdU) labelling. Expression of mucin core proteins (MUC), trefoil family factor (TFF) peptides <i>LGR5</i> mRNA determined immunohistochemistry or situ...
Patients with Barrett's oesophagus are at increased risk of oesophageal adenocarcinoma. Observational studies have suggested increase in overall mortality also but data conflicting.To assess the cause death patients compared general population.Patients were identified retrospectively four hospitals Leicestershire, UK using electronic endoscopy and histopathology records from 1997 to 2003. Data on deaths this cohort through Office National Statistics age- gender-adjusted Leicestershire...
<h3>Background</h3> Little is known about the stem cell organisation of normal oesophagus or Barrett9s metaplastic oesophagus. Using non-pathogenic mitochondrial DNA mutations as clonal markers, authors reveal human squamous and metaplasia determine mechanism expansion mutations. <h3>Methods</h3> Mutated cells were identified using enzyme histochemistry to detect activity cytochrome <i>c</i> oxidase (CCO). CCO-deficient laser-captured confirmed by PCR sequencing. Cell lineages...
p53 immunostaining in Barrett's oesophagus (BO) has been shown to be predictive of progression, but data regarding its generalizability routine practice are lacking. This study compared the reliability and dysplasia interpretation grading.Seventy-two cases encompassing full spectrum BO were circulated 10 pathologists from four institutions after a brief training session interpretation. Each pathologist classified on haematoxylin eosin (H&E) alone using Vienna classification assessed staining...
The first case of amyloidosis is reported in which spontaneous massive hepatic haemorrhage necessitated emergency liver transplantation. Liver transplantation, as a treatment for failing due to has not been previously reported. At the tissue was uncharacteristically friable, although subsequent vascular and biliary anastomoses were uncomplicated. Histological examination showed surprisingly modest amount amyloid, shown immunohistochemically be derived from lysozyme, striking absence...