Claire Brooks
A5090581597- Pesticide Exposure and Toxicity
- Esophageal Cancer Research and Treatment
- Occupational and environmental lung diseases
- Health, Environment, Cognitive Aging
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Cancer Genomics and Diagnostics
- Occupational Health and Performance
- Genomics and Rare Diseases
- Carcinogens and Genotoxicity Assessment
- Helicobacter pylori-related gastroenterology studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Brain Metastases and Treatment
- SARS-CoV-2 and COVID-19 Research
- Health, psychology, and well-being
- Genetics and Neurodevelopmental Disorders
- Delphi Technique in Research
- Genetic factors in colorectal cancer
- Glioma Diagnosis and Treatment
- Eosinophilic Esophagitis
- SARS-CoV-2 detection and testing
- Infection Control and Ventilation
- Congenital Ear and Nasal Anomalies
- Hedgehog Signaling Pathway Studies
- Genetic Associations and Epidemiology
University of Bradford
2025
Great Ormond Street Hospital for Children NHS Foundation Trust
2020-2023
University of Oxford
2009-2023
University of Liverpool
2005-2021
London North West Healthcare NHS Trust
2020-2021
St Mark's Hospital
2020-2021
Liverpool Women's Hospital
2021
Institute of Cancer Research
2021
University College London Hospitals NHS Foundation Trust
2020
University College London
2020
Oesophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's oesophagus biggest risk factor. We aimed to evaluate efficacy high-dose esomeprazole proton-pump inhibitor (PPI) aspirin for improving outcomes in patients with oesophagus.
Abstract Background Median survival for patients with glioblastoma is less than a year. Standard treatment consists of surgical debulking if feasible followed by temozolomide chemo-radiotherapy. The immune checkpoint inhibitor ipilimumab targets cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and has shown clinical efficacy in preclinical models glioblastoma. aim this study to explore the addition standard therapy Methods/design Ipi-Glio phase II, open label, randomised (Arm A) versus...
Dignity is widely recognized as a foundational concept in the provision of healthcare. Despite this, concepts dignity are only vaguely described literature relating to mental health services, contributing frequent violations service users’ dignity. Notably, discussions services often do not include user perspective. We offer narrative review examine how users and peer workers articulate co-production within services. Seven overarching dimensions emerge from available evidence, spanning...
Abstract Background Glioblastoma confers a bleak prognosis, with median survival of less than year. This trial evaluated whether addition the CTLA-4 immune checkpoint inhibitor ipilimumab to standard therapy improves in patients recently diagnosed glioblastoma. Methods Ipi-Glio was stratified randomised, open label, multicentre, academic phase II study. Patients de-novo glioblastoma following completion chemo-radiotherapy were randomised 2:1 + temozolomide (Arm A) versus alone B), extent...
Hermansky-Pudlak syndrome 2 (HPS2; OMIM #608233) is a rare, autosomal recessive disorder caused by loss-of-function genetic variations affecting AP3B1, which encodes the β3A subunit of adaptor-related protein complex 3 (AP3). Phenotypic characteristics include reduced pigmentation, absent platelet dense granule secretion, neutropenia and cytotoxic T lymphocyte (CTL) natural killer (NK) cell function. To date HPS2 has been associated with non-synonymous, stop-gain or deletion-insertion...
To describe national patterns of National Health Service (NHS) analysis mismatch repair (MMR) genes in England using individual-level data submitted to the Disease Registration (NDRS) by NHS regional molecular genetics laboratories.
LBA2023 Background: Median survival for patients with glioblastoma is less than a year. Standard treatment comprises surgical debulking if feasible followed by temozolomide (TMZ) chemoradiotherapy. The objective of this clinical trial to evaluate whether the addition CTLA-4 immune checkpoint inhibitor ipilimumab (IPI) improves survival. Methods: Ipi-Glio an academic phase II, open label, stratified randomised multicentre study IPI + TMZ (Arm A) vs alone B), after surgery and radical...
<b>Objective</b> To investigate any long term effects on mortality in participants experimental research related to chemical warfare agents from 1941 1989. <b>Design</b> Historical cohort study. <b>Data sources </b>Archive of UK government facility at Porton Down, military personnel records, and national death cancer records. <b>Participants </b>18 276 male members the armed forces who had spent one or more short periods (median 4 days between first last test) Down a comparison group 17 600...
<b>Objective</b> To determine cancer morbidity in members of the armed forces who took part tests chemical warfare agents from 1941 to 1989. <b>Design</b> Historical cohort study, with followed up December 2004. <b>Data source </b>Archive UK government research facility at Porton Down, military personnel records, and national death records. <b>Participants</b> All veterans included study mortality, excluding those known have died or been lost follow-up before 1 January 1971 when registration...
PurposeConditions and thresholds applied for evidence weighting of within-codon concordance (PM5) pathogenicity vary widely between laboratories expert groups. Because the sparseness available clinical classifications, there is little variation in practice.MethodsWe used as a truthset 7541 dichotomous functional classifications BRCA1 MSH2, spanning 311 codons 918 generated from large-scale assays that have been shown to correlate excellently with classifications. We assessed PM5 at 5...
This study describes exposures to military veterans who participated between 1941 and 1989 in British research at Porton Down on the effects of exposure chemical warfare agents defences against those agents. The is part a programme epidemiological initiated response service veterans' concerns about possible long-term health their participation.All entries 97 books held historical experimental archive covering years 1939-1989 were reviewed. For tests April December 1989, data abstracted...
Background National and international amalgamation of genomic data offers opportunity for research audit, including analyses enabling improved classification variants uncertain significance. Review individual-level from Health Service (NHS) testing cancer susceptibility genes (2002–2023) submitted to the Disease Registration revealed heterogeneity across participating laboratories regarding (1) structure, quality completeness data, (2) ease with which that could be assembled locally...
The UK government has carried out a research programme studying military capability under conditions of chemical warfare at facility Porton Down, Wiltshire, since World War I. In 2001 the Ministry Defence commissioned cohort study to investigate long-term health effects on veterans their participation in this programme. We assessed availability and quality exposure assessment data held archive Down for purpose study. This involved looking detail sample 150 undertaking general review all...
Background There has been a Human Volunteer Programme at the British chemical weapons research facility Porton Down since First World War, in which some of participants were exposed to warfare agents. Aim To identify any striking specific morbidity patterns members Veterans Support Group (PDVSG). Methods A self-completed postal questionnaire was prepared including health immediately after visits Down, subsequent diagnoses and hospital admissions, symptoms in, after, first 5 years visits,...
The effects of exposure to chemical warfare agents in humans are topical. Porton Down is the UK's centre for research on where, since WWI, a programme experiments involving ~30000 participants drawn from UK armed services has been undertaken.Our aim report exposures nerve agents, particularly sarin, using detailed data not explored previous analysis.In this paper, we have used existing servicemen who attended human volunteer at examine general and sarin particular.Six principal were tested...
LBA4008 Background: Esophageal adenocarcinoma (EA) is the sixth most common cause of global cancer death. We rely on endoscopy screening to identify and monitor patients with Barrett’s esophagus (BE) find neoplastic lesions early enough manage their EA. This approach has a modest effect EA supported by low quality evidence. evaluated efficacy aspirin high dose acid suppression in preventing BE. Methods: recruited ≥ 1cm BE no grade dysplasia (HGD) or at baseline UK Canadian hospitals. To...
TPS5615 Background: BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair have been implicated familial breast ovarian cancer tumorigenesis. Tumor cells with these mutations demonstrate increased sensitivity to cisplatin poly(ADP-ribose) polymerase (PARP) inhibitors. 6MP was identified a screen for novel drugs found selectively kill BRCA-defective xenograft model as effectively the PARP inhibitor, AGO14699, even after had acquired resistance inhibitor or (Issaeva 2010)....