A5083650031- Adipose Tissue and Metabolism
- Thermoregulation and physiological responses
- Exercise and Physiological Responses
- Liver Disease Diagnosis and Treatment
- Nutritional Studies and Diet
- Indigenous Studies and Ecology
- Climate Change and Health Impacts
- Hepatitis C virus research
- Diet and metabolism studies
- Animal Behavior and Reproduction
- Obesity and Health Practices
- Thyroid Disorders and Treatments
- Insect and Arachnid Ecology and Behavior
- Plant and animal studies
- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Smoking Behavior and Cessation
- High Altitude and Hypoxia
- Neuroendocrine regulation and behavior
- Paleopathology and ancient diseases
- Multiculturalism, Politics, Migration, Gender
- Genetic and Kidney Cyst Diseases
- Mediterranean and Iberian flora and fauna
- Biological Control of Invasive Species
- Cancer Immunotherapy and Biomarkers
New York Consortium in Evolutionary Primatology
2020-2025
Hunter College
2018-2025
University of Oxford
2022-2025
Yale University
2018-2019
Northwestern University
2013-2016
University of Reading
2016
Université de Reims Champagne-Ardenne
2006-2012
Centre Hospitalier Universitaire de Reims
2006-2012
University of Michigan
2009-2011
Hasbro (United States)
2010
ObjectivesTo determine safety and efficacy of the 5HT1A serotonin partial agonist buspirone on core autism associated features in children with spectrum disorder (ASD).Study designChildren 2-6 years age ASD (N = 166) were randomized to receive placebo or 2.5 5.0 mg twice daily. The primary objective was evaluate effects 24 weeks Autism Diagnostic Observation Schedule (ADOS) Composite Total Score. Secondary objectives included evaluating social competence, repetitive behaviors, language,...
Journal Article Late lethal hepatitis B virus reactivation after rituximab treatment of low‐grade cutaneous B‐cell lymphoma Get access G. Perceau, Perceau CHU de Reims, Hôpital Robert‐Debré, Service Dermatologie et *Service Gastroentérologie, avenue du Général Koenig, 51092 Reims Cedex, France Search for other works by this author on: Oxford Academic Google Scholar N. Diris, Diris O. Estines, Estines C. Derancourt, Derancourt S. Lévy, Lévy P. Bernard Pr Bernard. E‐mail: pbernard@chu‐reims.fr...
ABSTRACT Objectives: Previous research has shown that indigenous circumpolar populations have elevated basal metabolic rates (BMRs), yet few studies explored whether increase during the winter. This study addresses this gap by examining seasonal variation in BMR and its associations with thyroid function lifestyle factors among Yakut (Sakha) of Siberia. Methods: Anthropometric dimensions, BMR, hormone levels (free triiodothyronine [fT3], free thyroxine [fT4], thyroid‐stimulating [TSH]) were...
Many animals use signals to assess the fighting ability of rivals and reduce cost aggressive competition. However, little is known about how an individual's own quality influences their signal assessment decisions. Polistes dominulus wasps have visual that provide a good model for testing dynamics rival choice. We found behaviour was influenced by advertised individual, rivals, interaction between individual quality. Individuals high were more likely challenge individuals low be challenged....
Abstract Objectives Recent research suggests that brown adipose tissue (BAT) plays a functional role in non‐shivering thermogenesis; however, few studies have examined population variation BAT or its relationship with other mechanisms of adaptation to cold stress. This study characterized thermogenesis and adaptive responses low temperatures among Indigenous Siberian young adults living near Chicago, IL. Materials methods We recruited 72 Yakut participants (42 females; 30 males) 54 Evanston,...
Background The built environment buffers residents of large cities, such as New York (NYC), from exposure to low temperatures. Furthermore, average winter temperatures are rising in NYC due climate change. degree which exhibit metabolic adaptations cold stress is currently unclear.
Abstract Background Glioblastoma confers a bleak prognosis, with median survival of less than year. This trial evaluated whether addition the CTLA-4 immune checkpoint inhibitor ipilimumab to standard therapy improves in patients recently diagnosed glioblastoma. Methods Ipi-Glio was stratified randomised, open label, multicentre, academic phase II study. Patients de-novo glioblastoma following completion chemo-radiotherapy were randomised 2:1 + temozolomide (Arm A) versus alone B), extent...
Objectives Previous research has shown that the extreme cold and short day lengths of polar winters promote increased production uptake thyroid hormones, resulting in marked declines free triiodothyronine (fT3). However, this “polar T3 syndrome” been documented almost exclusively on small samples male sojourners little is known about seasonal changes function among indigenous circumpolar groups. The present study addresses gap by examining hormone levels Yakut (Sakha) northeastern Siberia....
Abstract Objectives This study provides the first investigation of non‐shivering thermogenesis (NST) and brown adipose tissue (BAT) activity among an indigenous circumpolar population, Yakut northeastern Siberia. The also examines health significance BAT in this population by testing relationships between biomarkers cardio‐metabolic disease risk, such as percent body fat blood glucose cholesterol levels. Methods Data were collected Sakha Republic (Yakutia) for 31 men 43 women. Change energy...
ABSTRACT Objectives Among indigenous circumpolar populations, extreme seasonality influences food availability and energy metabolism. Furthermore, subsistence patterns wage labor opportunities shift with season. Thus, health measures among populations likely exhibit seasonal changes that are influenced by lifestyle factors. This study examines how markers of cardio‐metabolic vary between summer winter as a function an individual's sex the Yakut northeastern Siberia. Methods Anthropometric...
Abstract Objectives Increasing obesity rates and accelerating climate change represent two global health challenges shaped by lifestyle human environmental modifications. Yet, few studies have considered how these issues may interact to exacerbate disease risk. Methods In this theory article, we explore evidence that obesity‐related climatic changes share socio‐ecological drivers increase morbidity mortality risks. Additionally, consider obesity‐climate interactions disproportionately affect...
Abstract Objectives Evolutionary theorists have debated the adaptive significance of developmental plasticity in organisms with long lifespans such as humans. This debate part stems from uncertainty regarding timing sensitive periods. Does sensitivity to environmental signals fluctuate across development or does it steadily decline? We investigated brown adipose tissue (BAT) among indigenous Siberians order explore phenotypic cold stress. Methods BAT thermogenesis was quantified using...
Abstract Objectives This study investigates the energetic costs associated with Oldowan‐style flake production and how skill differences influence these costs. Materials Methods Nine adult participants, including novice expert toolmakers, underwent a 2‐h experimental session where we measured energy expenditure flaking outcomes. We body mass (kg), percent fat, fat‐free (kg) used open‐circuit indirect calorimetry to quantify expenditure. The lithic analysis standard linear measurements on...
Abstract Non‐shivering thermogenesis (NST) is a metabolic response to acute cold exposure that involves the liberation of chemical energy through physiological mechanisms are separate from muscle shivering. Recent research suggests and endocrine action brown adipose tissue (BAT) may play an important role in adult human NST. Thus, characterizing variation BAT across populations central importance biologists interested energetics cardio‐metabolic health. The gold standard for measuring...
LBA2023 Background: Median survival for patients with glioblastoma is less than a year. Standard treatment comprises surgical debulking if feasible followed by temozolomide (TMZ) chemoradiotherapy. The objective of this clinical trial to evaluate whether the addition CTLA-4 immune checkpoint inhibitor ipilimumab (IPI) improves survival. Methods: Ipi-Glio an academic phase II, open label, stratified randomised multicentre study IPI + TMZ (Arm A) vs alone B), after surgery and radical...
BackgroundEffective surveillance strategies are required for patients diagnosed with oesophageal squamous cell carcinoma (OSCC) or adenocarcinoma (OAC) whom chemoradiotherapy (CRT) is used as a potentially-curative, organ-sparing, alternative to surgery. In this study, we evaluated the safety, acceptability and tolerability of non-endoscopic immunocytological device (the Cytosponge™) assess treatment response following CRT.MethodsThis multicentre, single-arm feasibility trial took place in...
Recent studies in adults indicate that cold-induced temperature change of supraclavicular skin corresponds with brown adipose tissue (BAT) thermogenesis.This study examined the feasibility using thermography to assess changes infants aged 18-25 months after mild cooling. Further, this sought evaluate whether cold exposure induces a thermal response suggestive BAT activity underlying region.Changes maximum at and interscapular regions were determined imaging following 5-minute cooling...