A5005560477- Anesthesia and Sedative Agents
- Mechanical Circulatory Support Devices
- Vaccine Coverage and Hesitancy
- Antibiotics Pharmacokinetics and Efficacy
- Virology and Viral Diseases
- Pharmaceutical studies and practices
- SARS-CoV-2 and COVID-19 Research
- Smoking Behavior and Cessation
- Heart Failure Treatment and Management
- Cardiac Arrest and Resuscitation
- Urinary Bladder and Prostate Research
- Airway Management and Intubation Techniques
- Respiratory viral infections research
- Emergency and Acute Care Studies
- Trauma Management and Diagnosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Homicide, Infanticide, and Child Abuse
- Homelessness and Social Issues
- Cardiac, Anesthesia and Surgical Outcomes
- Child Abuse and Trauma
- Attention Deficit Hyperactivity Disorder
- Pharmacological Effects and Toxicity Studies
- Antibiotic Resistance in Bacteria
- Child and Adolescent Health
- Metabolism and Genetic Disorders
Rainbow Babies & Children's Hospital
2013-2025
Case Western Reserve University
2014-2015
University of Waterloo
2015
ObjectivesTo determine safety and efficacy of the 5HT1A serotonin partial agonist buspirone on core autism associated features in children with spectrum disorder (ASD).Study designChildren 2-6 years age ASD (N = 166) were randomized to receive placebo or 2.5 5.0 mg twice daily. The primary objective was evaluate effects 24 weeks Autism Diagnostic Observation Schedule (ADOS) Composite Total Score. Secondary objectives included evaluating social competence, repetitive behaviors, language,...
Procedural sedation/anesthesia outside the operating room for a variety of procedures is well described with an overall low adverse event rate in certain settings. Adverse associated procedural gastrointestinal have been described, albeit small, single-center studies wide variance outcomes. Predictors such outcomes are unclear. We aimed to estimate prevalence children undergoing esophagogastroduodenoscopy, colonoscopy, or both identify predictors event.Retrospective analysis Pediatric...
This study aimed to investigate the pharmacokinetics (PK), safety, and tolerability of a single dose ceftazidime-avibactam in pediatric patients. A phase I, multicenter, open-label PK was conducted patients hospitalized with an infection receiving systemic antibiotic therapy. Patients were enrolled into four age cohorts (cohort 1, ≥12 <18 years; cohort 2, ≥6 <12 3, ≥2 <6 4, ≥3 months <2 years). received 2-h intravenous infusion 2,000 500 mg; mg [≥40 kg] or 50 12.5 mg/kg [<40 kg]; 3 mg/kg)....
Objectives To describe nationally representative outcomes of physical abuse injuries in children necessitating Emergency Department (ED) visits United States. The impact various on mortality is examined. We hypothesize that resulting intracranial are associated with worse outcome. Materials and Methods performed a retrospective analysis the Nationwide Sample (NEDS), largest all payer hospital based ED database, for years 2008–2010. All subsequent hospitalizations diagnosis “Child abuse”...
MMR II (M-M-R [Merck & Co, Inc.]) is currently the only measles, mumps, and rubella (MMR) vaccine licensed in United States. A second would mitigate potential risk of supply shortage or delay. In this study, we assessed immunogenicity safety another (MMR-RIT [Priorix, GlaxoSmithKline]) compared with those 12- to 15-month-old children who received it as a first dose.In phase III, observer-blinded, noninferiority, lot-to-lot consistency clinical trial (ClinicalTrials.gov identifier...
Abstract Milrinone is a type 3 phosphodiesterase inhibitor used to improve cardiac output in critically ill infants and children. primarily excreted unchanged the urine, raising concerns for toxic accumulation setting of renal dysfunction critical illness. We developed population pharmacokinetic model milrinone using nonlinear mixed‐effects modeling NONMEM perform dose‐exposure simulations children with variable function. included aged <21 years who received intravenous per clinical care....
Abstract Differences in fentanyl pharmacokinetics (PK) between obese and nonobese adults have previously been reported; however, the impact of childhood obesity on PK is relatively unknown. We developed a population pharmacokinetic (PopPK) model using opportunistically collected samples from cohort predominately children receiving per standard care. Using probability‐based approach, we evaluated ability different continuous infusion strategies to provide steady‐state concentrations (C ss )...
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Das, Ashima1; Anderson, Ingrid1; Speicher, David2; Richard3; Shein, Steven3; Rotta, Alexandre4 Author Information
Rampa, Sankeerth; Das, Ashima; Allareddy, Veerasathpurush; Rotta, Alexandre; Veerajalandhar; Speicher, David Author Information
Allareddy, Veerajalandhar1; Rampa, Sankeerth2; Das, Ashima3; Nalliah, Romesh4; Speicher, David1; Rotta, Alexandre1; Veerasathpurush5 Author Information
Das, Ashima1; Rampa, Sankeerth2; Nalliah, Romesh3; Allareddy, Veerasathpurush4; Speicher, David5; Rotta, Alexandre5; Veerajalandhar5 Author Information
Allareddy, Veerajalandhar; Rampa, Sankeerth; Das, Ashima; Nalliah, Romesh; Veerasathpurush; Speicher, David; Rotta, Alexandre Author Information
Rampa, Sankeerth; Das, Ashima; Allareddy, Veerasathpurush; Speicher, David; Veerajalandhar; Rotta, Alexandre Author Information
Das, Ashima; Rampa, Sankeerth; Nalliah, Romesh; Allareddy, Veerasathpurush; Speicher, David; Rotta, Alexandre; Veerajalandhar Author Information
Rampa, Sankeerth1; Nalliah, Romesh2; Allareddy, Veerasathpurush3; Speicher, David4; Veerajalandhar4; Rotta, Alexandre4 Author Information
Introduction: Pediatric Sedation Anesthesia- Outside Operating Room (PSA-OOR) is well described with overall low adverse events (AE) in certain settings. AE associated PSA-OOR for Gastro-Intestinal procedures have been small single center studies wide variance outcomes. Predictors of such outcomes are unclear. Estimating the incidence children undergoing Esophagogastroduodenoscopy (EGD), Colonoscopy (Col), or both may help identify predictors AE. Methods: Retrospective analysis prospectively...
Introduction: Child Maltreatment Syndrome is a spectrum ranging from neglect to abuse. Identification of risk factors may enhance Emergency Department(ED) physicians screening for potential child maltreatment syndrome. Current national estimates and hospital resource utilization associated with syndrome are unclear. Methods: The Nationwide Department Sample (for year 2009) the Healthcare Cost Utilization Project sponsored by Agency Research Quality was used. A retrospective analysis all ED...
Introduction: Alcohol use and abuse among children (aged ≤ 21 years) is a persistent pervasive problem worldwide. Underage drinking associated with high risk behaviors significant negative societal outcomes. Hospital resource utilization outcomes alcohol necessitating Emergency department(ED) visits are unclear. Methods: The Nationwide Department Sample (for year 2009) of the Healthcare Cost Utilization Project sponsored by Agency for Research Quality was used. We performed retrospective...