A5020317135- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Radiopharmaceutical Chemistry and Applications
- Neurological disorders and treatments
- Cerebrospinal fluid and hydrocephalus
- Advanced MRI Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Brain Metastases and Treatment
- Medical Imaging Techniques and Applications
- Neurosurgical Procedures and Complications
- Radiomics and Machine Learning in Medical Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Diet and metabolism studies
- Neuroscience and Neuropharmacology Research
- Head and Neck Surgical Oncology
- Pituitary Gland Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Nanoplatforms for cancer theranostics
- COVID-19 and healthcare impacts
- RNA modifications and cancer
- Transcranial Magnetic Stimulation Studies
- Spinal Fractures and Fixation Techniques
Oxford University Hospitals NHS Trust
2015-2025
John Radcliffe Hospital
2016-2025
University of Oxford
2016-2025
Nuffield Orthopaedic Centre
2022-2025
Brain Tumour Charity
2024
All India Institute of Medical Sciences Raipur
2024
All India Institute of Medical Sciences
2024
All India Institute of Medical Sciences Bhopal
2024
Wellcome Centre for Integrative Neuroimaging
2018
Frenchay Hospital
2004-2015
Deep brain stimulation (DBS) has an increasing role in the treatment of idiopathic Parkinson's disease. Although, subthalamic nucleus (STN) is commonly chosen target, a number groups have reported that most effective contact lies dorsal/dorsomedial to STN (region pallidofugal fibres and rostral zona incerta) or at junction between dorsal border latter. We analysed our outcome data from disease patients treated with DBS April 2002 June 2004. During this period we moved target region...
Gait disturbance and postural instability are some the most disabling symptoms of idiopathic Parkinson's disease in late stage can be resistant to both medical surgical therapies. We implanted bilateral deep brain stimulation electrodes into pedunculopontine nucleus two patients with advanced disease. demonstrate for first time that low frequency (20-25 Hz) this significantly improves gait dysfunction 'on' 'off' medication states. Their combined total Unified Disease Rating Scale score...
Abstract We have shown previously that intraparenchymal infusion of glial cell line–derived neurotrophic factor (GDNF) continuously into the posterior putamen in five Parkinson's disease patients is safe and may represent a new treatment option. Here, we report continuation this phase I study. After 2 years continual GDNF infusion, there were no serious clinical side effects significant detrimental on cognition. Patients showed 57% 63% improvement their off‐medication motor activities daily...
<h3>Introduction:</h3> The ventrolateral (VL) nucleus of the thalamus is commonly chosen target for deep brain stimulation (DBS) to alleviate tremor. However, it has a poor efficacy in alleviating proximal tremor and patients may develop tolerance action component We performed bilateral caudal or motor part zona incerta (cZI) determine its safety <h3>Methods:</h3> 5 with parkinsonian 13 range tremors (Holmes (HT), cerebellar (CT), essential (ET), multiple sclerosis (MS) dystonic (DT))...
Abstract Mutations in the isocitrate dehydrogenase genes (IDH1/2) occur often diffuse gliomas, where they are associated with abnormal accumulation of oncometabolite 2-hydroxyglutarate (2-HG). Monitoring 2-HG levels could provide prognostic information this disease, but detection strategies that noninvasive and sufficiently quantitative have yet to be developed. In study, we address need by presenting a proton magnetic resonance spectroscopy (1H-MRS) acquisition scheme uses an ultrahigh...
Introduction Given its proximity to the central nervous system, surgical site infections (SSIs) after craniotomy (SSI-CRAN) represent a serious adverse event. SSI-CRAN are associated with substantial patient morbidity and mortality. Despite recognition of SSI in other fields, there is paucity evidence neurosurgical literature devoted skin closure, specifically patients brain tumors. The primary objective this service evaluation ascertain incidence risk factors SSI-CRAN. secondary objectives...
Object. The goal of this study was to determine the safety and efficacy bilateral subthalamic region stimulation in treatment essential tremor (ET). Methods. Following induction general anesthesia, four patients with disabling that had proved be refractory pharmacotherapy underwent magnetic resonance imaging—guided deep brain (DBS) region. Tremor assessed by applying Fahn-Tolosa-Marín Rating Scale at baseline again 12-month follow-up examination. surgery total score improved 80.1% (from a...
<h3>Background</h3> Over the past few years, bilateral stimulation of caudal or motor part zona incerta nucleus (cZI) has been performed by authors in patients with essential tremor (ET). Outcomes including quality life data 15 a follow-up period up to 84 months (mean 31.7±28.6 months) are presented. <h3>Methods</h3> consecutive ET underwent MRI guided cZI deep brain implantation. Patients were assessed applying Fahn–Tolosa–Marin Tremor Rating Scale and Short Form Health Survey-36 (SF-36)...
Abstract Background Glioblastoma (GBM) is the most common and malignant primary brain tumor in adults. Despite maximal treatment, median survival remains dismal at 14–24 months. Immunotherapies, such as checkpoint inhibition, have revolutionized management of some cancers but little benefit for GBM patients. This is, part, due to low mutational neoantigen burden this immunogenically “cold” tumor. Methods U87MG patient-derived cell lines were treated with 5-aza-2′-deoxycytidine (DAC)...
OBJECTIVE We present a magnetic resonance imaging-directed stereotactic system using implantable guide tubes for targeting deep brain nuclei in functional neurosurgery. METHODS Our method relies on visualization of the high-resolution images that delineate target boundaries and enable direct specific regions nucleus. The delivery comprises modified stereoguide capable delivering an tube to vicinity desired target. (in-house investigational device) has hub at its proximal end is fixed within...
Introduction. Axial symptoms including postural instability, falls and failure of gait initiation are some the most disabling motor Parkinson's disease (PD). We performed bilateral deep brain stimulation (DBS) pedunculopontine nucleus (PPN) in combination with caudal zona incerta (cZi) order to determine their efficacy alleviating these symptoms.
Abstract Background The molecular genetic classification of gliomas, particularly the identification isocitrate dehydrogenase (IDH) mutations, is critical for clinical and surgical decision-making. Raman spectroscopy probes unique vibrations a sample to accurately characterize its composition. No processing required allowing rapid analysis tissue. aim this study was evaluate ability rapidly identify common subtypes diffuse glioma in neurosurgical setting using fresh biopsy In addition,...
OBJECTIVE Raman spectroscopy is a biophotonic tool that can be used to differentiate between different tissue types. It nondestructive and no sample preparation required. The aim of this study was evaluate the ability glioma normal brain when using fresh biopsy samples and, in case glioblastomas, compare performance predict presence or absence tumor with 5-aminolevulinic acid (5-ALA)–induced fluorescence. METHODS A principal component analysis (PCA)–fed linear discriminant (LDA) machine...
Group II metabotropic glutamate receptor (mGluR) ligands are potential novel drugs for neurological and psychiatric disorders, but little is known about the effects of these compounds at synapses human cerebral cortex. Investigating neuropsychiatric in brain tissue with preserved synaptic circuits might accelerate development more potent selective pharmacological treatments. We have studied group mGluR activation on excitatory transmission recorded from pyramidal neurons cortical layers 2-3...
We aim to describe the outcomes after chronic subdural hematoma drainage (CSDH) management in a large cohort of patients on antithrombotic drugs, either antiplatelets or anticoagulants, at presentation and inform clinical decision making timing surgery recommencement these drugs. used data from previous UK-based multi-center, prospective study. Outcomes included recurrence within 60 days, functional outcome discharge, thromboembolic event during hospital stay. performed Cox regression...
To clarify the outcome of all cases Rathke's cleft cysts (RCC) treated surgically and followed up in Oxford during a long-term period.The records patients with RCC seen Department Endocrinology between January 1978 June 2009 were reviewed.A total 33 (20 females, median age 43 years) identified. At presentation, major visual field defects detected 58% gonadotrophin, ACTH TSH deficiency 60, 36 36% respectively. Desmopressin treatment was required 18% patients. Treatment consisted cyst...
Abstract Magnetic resonance spectroscopic imaging (MRSI) is a promising technique in both experimental and clinical settings. However, to date, MRSI has been hampered by prohibitively long acquisition times artifacts caused subject motion hardware-related frequency drift. In the present study, we demonstrate that density weighted concentric ring trajectory (DW-CRT) k-space sampling combination with semi-LASER excitation metabolite-cycling enables high-resolution data be rapidly acquired at 3...
Objectives Pressures on healthcare systems due to COVID-19 has impacted patients without with surgery disproportionally affected. This study aims understand the impact initial management of brain tumours by measuring changes normal multidisciplinary team (MDT) decision making. Design A prospective survey performed in UK neurosurgical units from 23 March 2020 until 24 April 2020. Setting Regional outside London (as pandemic was more advanced at time study). Participants Representatives all...