A5101528549- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Glioma Diagnosis and Treatment
- Nerve injury and regeneration
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Spine and Intervertebral Disc Pathology
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Advanced MRI Techniques and Applications
- Spinal Fractures and Fixation Techniques
- Epilepsy research and treatment
- Cervical and Thoracic Myelopathy
- Neuroscience and Neural Engineering
- Autism Spectrum Disorder Research
- Virus-based gene therapy research
- Advanced Neuroimaging Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- RNA Interference and Gene Delivery
- Fetal and Pediatric Neurological Disorders
- Radiomics and Machine Learning in Medical Imaging
- Viral Infectious Diseases and Gene Expression in Insects
Imperial College London
2012-2025
University of Bristol
2012-2023
Frimley Park Hospital
2023
North Bristol NHS Trust
2019
Renishaw (United Kingdom)
2015-2019
London Women's Clinic
2019
Southmead Hospital
2011-2018
University of Arizona Cancer Center
2018
Frenchay Hospital
2007-2016
Bristol Royal Hospital for Children
1997-2016
Abstract Objective Glial cell line–derived neurotrophic factor (GDNF) exerts potent trophic influence on midbrain dopaminergic neurons. This randomized controlled clinical trial was designed to confirm initial benefits observed in a small, open‐label using intraputamenal (Ipu) infusion of recombinant human GDNF (liatermin). Methods Thirty‐four PD patients were 1 receive bilateral continuous Ipu liatermin 15μg/putamen/day or placebo. The primary end point the change Unified Parkinson Disease...
Gait disturbance and postural instability are some the most disabling symptoms of idiopathic Parkinson's disease in late stage can be resistant to both medical surgical therapies. We implanted bilateral deep brain stimulation electrodes into pedunculopontine nucleus two patients with advanced disease. demonstrate for first time that low frequency (20-25 Hz) this significantly improves gait dysfunction 'on' 'off' medication states. Their combined total Unified Disease Rating Scale score...
Abstract We have shown previously that intraparenchymal infusion of glial cell line–derived neurotrophic factor (GDNF) continuously into the posterior putamen in five Parkinson's disease patients is safe and may represent a new treatment option. Here, we report continuation this phase I study. After 2 years continual GDNF infusion, there were no serious clinical side effects significant detrimental on cognition. Patients showed 57% 63% improvement their off‐medication motor activities daily...
We investigated the effects of glial cell line-derived neurotrophic factor (GDNF) in Parkinson’s disease, using intermittent intraputamenal convection-enhanced delivery via a skull-mounted transcutaneous port as novel administration paradigm to potentially afford putamen-wide therapeutic delivery. This was single-centre, randomized, double-blind, placebo-controlled trial. Patients were 35–75 years old, had motor symptoms for 5 or more years, and presented with moderate disease severity OFF...
Proton magnetic resonance spectroscopy (1H MRS) was used to investigate intracranial tumours in vitro and vivo. Biopsy specimens were studied from 47 patients, 11 of whom also examined Analysis based on the signals N-acetylaspartate (NAA), phosphocreatine plus creatine (Cr), choline-containing compounds (Cho), alanine (Ala), lactate. data 26 astrocytomas showed that NAA/Cr ratio differs significantly all grades its value normal white matter Cho/Cr grade IV other grades. Meningiomas have an...
Object. To assess the effectiveness of Cummins' artificial cervical joint, authors reviewed cases 20 patients in whom joint had been placed. Methods. A review patients' medical records and reexamination 18 were performed. The surgical experience with implantation movable stainless-steel joints treated for myelopathy (16 patients), radiculopathy (three severe pain (one patient) indicated that procedure is safe well tolerated does preserve motion most over an extended period observation. date,...
<h3>Introduction:</h3> The ventrolateral (VL) nucleus of the thalamus is commonly chosen target for deep brain stimulation (DBS) to alleviate tremor. However, it has a poor efficacy in alleviating proximal tremor and patients may develop tolerance action component We performed bilateral caudal or motor part zona incerta (cZI) determine its safety <h3>Methods:</h3> 5 with parkinsonian 13 range tremors (Holmes (HT), cerebellar (CT), essential (ET), multiple sclerosis (MS) dystonic (DT))...
Object. The authors report the preservation of motion at surgically treated and adjacent spinal segments after placing an artificial cervical joint (ACJ) they describe influence interbody fusion on changes in angulation occurring sagittal plane levels treatment spondylosis. Methods. conducted a prospective nonrandomized study patients whom ACJ was placed or autologous bone graft performed. Angular measurements to that were calculated using plain flexion—extension radiographs obtained 6-month...
Hyperactivity in the subthalamic nucleus (STN) is seen animal models of Parkinson's disease, and lesioning STN dramatically relieves animal's parkinsonism. Deep brain stimulation (DBS) an effective treatment for patients with advanced disease. We have studied effects a unilateral lesion placed predominantly hemi-parkinsonian patients. Twenty-one idiopathic disease were studied. Seventeen had asymmetrical tremor-dominant four bilateral All underwent radiofrequency dorsolateral part under...
Background: Intraputamenal glial cell line-derived neurotrophic factor (GDNF), administered every 4 weeks to patients with moderately advanced Parkinson's disease, did not show significant clinical improvements against placebo at 40 weeks, although it significantly increased [ 18 F]DOPA uptake throughout the entire putamen.Objective: This open-label extension study explored effects of continued (prior GDNF patients) or new exposure for another weeks.Methods: Using infusion protocol parent...
Study Design. A clinical prospective observational cohort study of 15 patients undergoing cervical intervertebral disc replacement. Objective. To assess the safety, stability, and capacity a newly designed replacement for preserving motion in spine with degenerative disease. Summary Background Data. Anterior discectomy interbody fusion results loss segments there is evidence accelerated changes occurring at adjacent levels. Intervertebral may be valid alternative to fusion. There need...
Abstract 1 H NMR spectroscopy of human brain in vivo can be used to detect a number cerebral metabolites including N ‐acetylaspartate, creatine + phosphocreatine and choline‐containing compounds. We have analyse these signals (i) biopsy material from both normal astrocytomas, (ii) primary astrocyte cultures. On the basis this analysis, we conclude that could play an important clinical role non‐invasive assessment neuronal degeneration proliferation non‐neuronal cells.
Object. The goal of this study was to determine the safety and efficacy bilateral subthalamic region stimulation in treatment essential tremor (ET). Methods. Following induction general anesthesia, four patients with disabling that had proved be refractory pharmacotherapy underwent magnetic resonance imaging—guided deep brain (DBS) region. Tremor assessed by applying Fahn-Tolosa-Marín Rating Scale at baseline again 12-month follow-up examination. surgery total score improved 80.1% (from a...
<h3>Background</h3> Over the past few years, bilateral stimulation of caudal or motor part zona incerta nucleus (cZI) has been performed by authors in patients with essential tremor (ET). Outcomes including quality life data 15 a follow-up period up to 84 months (mean 31.7±28.6 months) are presented. <h3>Methods</h3> consecutive ET underwent MRI guided cZI deep brain implantation. Patients were assessed applying Fahn–Tolosa–Marin Tremor Rating Scale and Short Form Health Survey-36 (SF-36)...
We currently use Convection-Enhanced Delivery (CED) of the platinum-based drug, carboplatin as a novel treatment strategy for high grade glioblastoma in adults and children. Although initial results show promise, is not specifically toxic to tumour cells has been associated with neurotoxicity at infused concentrations pre-clinical studies. Our requires intermittent infusions due rapid clearance from brain. In this study, was encapsulated lactic acid-glycolic acid copolymer (PLGA) develop...
OBJECTIVE The pan-histone deacetylase inhibitor panobinostat has preclinical efficacy against diffuse intrinsic pontine glioma (DIPG), and the oral formulation entered a Phase I clinical trial. However, does not cross blood-brain barrier in humans. Convection-enhanced delivery (CED) is novel neurosurgical drug technique that bypasses of considerable interest treatment DIPG. METHODS authors investigated toxicity, distribution, clearance water-soluble (MTX110) small- large-animal model CED....
Context: Inadequate penetration of the blood–brain barrier (BBB) by systemically administered chemotherapies including carboplatin is implicated in their failure to improve prognosis for patients with glioblastoma. Convection-enhanced delivery (CED) has potential outcomes facilitating bypass BBB.Objective: We report first use an implantable CED system incorporating a novel transcutaneous bone-anchored port (TBAP) intermittent patient recurrent glioblastoma.Materials and methods: The catheter...