A5033925746- Glioma Diagnosis and Treatment
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Meningioma and schwannoma management
- Optical Imaging and Spectroscopy Techniques
- Transcranial Magnetic Stimulation Studies
- Radiomics and Machine Learning in Medical Imaging
- Traumatic Brain Injury and Neurovascular Disturbances
- Surgical site infection prevention
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Cerebrospinal fluid and hydrocephalus
- Radiopharmaceutical Chemistry and Applications
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Neural dynamics and brain function
- Lanthanide and Transition Metal Complexes
- CNS Lymphoma Diagnosis and Treatment
- Vestibular and auditory disorders
- Pituitary Gland Disorders and Treatments
- Photoacoustic and Ultrasonic Imaging
- Ethics in Clinical Research
- Intraoperative Neuromonitoring and Anesthetic Effects
- Ferroptosis and cancer prognosis
- Fetal and Pediatric Neurological Disorders
King's College Hospital NHS Foundation Trust
2020-2025
King's College Hospital
2020-2025
King's College London
2014-2024
Wellcome Centre for Human Neuroimaging
2022
Haywards Heath Hospital
2002
University Hospital of Wales
1996
The aim was to predict survival of glioblastoma at 8 months after radiotherapy (a period allowing for completing a typical course adjuvant temozolomide), by applying deep learning the first brain MRI completion.
Introduction Given its proximity to the central nervous system, surgical site infections (SSIs) after craniotomy (SSI-CRAN) represent a serious adverse event. SSI-CRAN are associated with substantial patient morbidity and mortality. Despite recognition of SSI in other fields, there is paucity evidence neurosurgical literature devoted skin closure, specifically patients brain tumors. The primary objective this service evaluation ascertain incidence risk factors SSI-CRAN. secondary objectives...
Introduction Hyperspectral imaging (HSI) has shown promise in the field of intra-operative and tissue differentiation as it carries capability to provide real-time information invisible naked eye whilst remaining label free. Previous iterations HSI systems have limitations, either due carrying a large footprint limiting ease use within confines neurosurgical theater environment, having slow image acquisition time, or by compromising spatial/spectral resolution favor improvements surgical...
Abstract Intracranial dermoid cysts are benign lesions that may be diagnosed incidentally or present symptomatically due to mass effect—focal neurological deficits, seizures and/or hydrocephalus—or chemical meningitis secondary spontaneous rupture. The use of tubular retractors in minimally invasive parafascicular surgery (tsMIPS) has been described extensively as a technique preserve function whilst safely maximizing the extent resection. authors first tsMIPS approach for removal cyst...
Abstract Objectives Glutaric aciduria type 1 (GA1) is a rare autosomal recessive organic acidaemia caused by deficiency of the glutaryl-CoA dehydrogenase enzyme. We describe outcomes following deep brain stimulation (DBS) for management dystonia children and adults with glutaric (GA1). Methods Cases GA1 were identified from institutional databases two tertiary movement disorder services. Data extracted clinical records using standardised proforma, including baseline characteristics, imaging...
Parkinson's disease is linked to increased beta oscillations in the subthalamic nucleus, which correlate with motor symptoms. However, findings across studies have varied. Our standardized analysis of multicenter datasets reveals that insufficient sample sizes contributed these discrepancies - a challenge we address by pooling into one large cohort (n=119). Moving beyond power, disentangled spectral components reflecting distinct neural processes. Combining aperiodic offset, low beta, and...
Background: The tubular retractor-assisted minimally invasive parafascicular approach (trMIPS) is a transsulcal to deep-seated brain tumours. It safe surgical but its impact on the microvascular dynamics of retracted cortex and clinical implications are unknown. Methods: This was single-centre prospective study including patients with tumours operated trMIPS (BrainPath Nico System©). All underwent pre- post-cannulation indocyanine green using FLOW 800 module in KINEVO Zeiss© microscope....
Abstract Control of the hand muscles during fine digit movements requires a high level sensorimotor integration, which relies on complex network cortical and subcortical hubs. The components this have been extensively studied in human non-human primates, but discrepancies findings obtained from different mapping approaches are difficult to interpret. In study, we defined connectional motor same cohort 20 healthy adults 3 neurosurgical patients. We used multimodal structural magnetic...
Abstract Background Repetitive transcranial magnetic stimulation (rTMS) is established for depression and rehabilitation after stroke emerging cognitive rehabilitation. We sought to evaluate patient carer perceptions toward rTMS neurosurgery. Methods Two surveys were undertaken. Group 1: Patients who received 7 days of motor or language severe postoperative deficits following lesional resection prospectively surveyed on the last day their treatment, as well next kin. 2: had previously been...
Although pneumothorax is the commonest presentation of pulmonary barotrauma unrelated to mechanical ventilation, systemic air embolism and emphysema within interstitium, mediastinum, retroperitoneum, pericardium, subcutaneous tissues have all been described.1 We report a case after inflation party balloons. A 24 year old previously healthy, non-smoker presented with 48 hour history sensation crackling under skin. His symptoms were initially confined neck but hours had affected his chest...
Deep learning-based (DL) methods are the best-performing for white matter tract segmentation in anatomically healthy subjects. However, annotations variable or absent clinical data and manual especially difficult patients with tumors where normal anatomy may be distorted. Direct cortical subcortical stimulation is gold standard ground truth to determine sub-cortical lo- cation of motor-eloquent areas intra-operatively. Nonetheless, this technique invasive, prolongs surgical procedure, cause...
We aim to demonstrate intraoperative recording of cerebellar cortical pathways that have not been previously recorded in humans, though imaged.We report 2 cases with neurophysiologic mapping cerebellocortical tracts. Direct electrical stimulation subcortical cerebellum along recordings evoked potential and motor muscle was performed during surgery. MR tractography data from healthy participants were used further illustrate the pathways.Neurophysiologic showed large waveforms potentials...
Abstract BACKGROUND Glioblastoma multiforme (GBM) portends poor prognosis despite multiple attempts at finding newer therapies. The current standard of care remains maximal safe resection. 5-ALA guidance helps to maximise the resection extent but complete removal is not always possible. It unclear, if residual pattern can predict outcome patients with GBM. MATERIALS & METHODS Patients GBM treated our centre between January 2018 - July 2019 were included they had based tumour excision...
Central nervous system lymphoma (CNSL) represents one of the most aggressive forms extranodal lymphoma. The gold standard for CNSL diagnosis remains stereotactic biopsy, with a limited role cytoreductive surgery that has not been supported by historical data. Our study aims to provide comprehensive overview neurosurgery's in systemic relapsed and primary CNSL, an emphasis on impact management survival. This is single center retrospective cohort data collected between August 2012 2020,...
Abstract BACKGROUND Patients with IDH-mutant, 1p/19-codeleted oligodendroglioma have a relatively favourable prognosis and can experience long periods of stable disease. Treatment modalities used vary, the long-term impacts both tumour itself its treatment on patient health-related quality life (HRQOL) cognition remain largely unclear. We aimed to investigate associations between functioning patients ≥5 years after diagnosis. MATERIAL AND METHODS In this international cross-sectional...