A5058969229- Optical Imaging and Spectroscopy Techniques
- Pain Management and Treatment
- Meningioma and schwannoma management
- Spine and Intervertebral Disc Pathology
- Pelvic and Acetabular Injuries
- Nanoplatforms for cancer theranostics
- Vascular Malformations Diagnosis and Treatment
- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Health Policy Implementation Science
- Orthopaedic implants and arthroplasty
- Artificial Intelligence in Healthcare and Education
- Traumatic Brain Injury and Neurovascular Disturbances
- Radiology practices and education
- Cardiac, Anesthesia and Surgical Outcomes
- Molecular Communication and Nanonetworks
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Abdominal Trauma and Injuries
- Cerebrovascular and Carotid Artery Diseases
- Patient-Provider Communication in Healthcare
- Surgical Simulation and Training
- Cervical and Thoracic Myelopathy
- Peripheral Artery Disease Management
- Trauma Management and Diagnosis
King's College London
2023-2025
King's College Hospital NHS Foundation Trust
2024
King's College Hospital
2023
Imperial College Healthcare NHS Trust
2019-2021
Barking, Havering And Redbridge University Hospitals NHS Trust
2020
Queen's Hospital
2020
Charing Cross Hospital
2019
University of Liverpool
2017-2018
Aintree University Hospital
2018
University of Cambridge
2017
Introduction Hyperspectral imaging (HSI) has shown promise in the field of intra-operative and tissue differentiation as it carries capability to provide real-time information invisible naked eye whilst remaining label free. Previous iterations HSI systems have limitations, either due carrying a large footprint limiting ease use within confines neurosurgical theater environment, having slow image acquisition time, or by compromising spatial/spectral resolution favor improvements surgical...
INTRODUCTION: Seizures are made up of the coordinated activity networks neurons. It follows that control neurons in pathologic circuits epilepsy could allow for disease. In non-human disease models epilepsy, optogenetics has been effective at stopping seizure-like by increasing inhibitory tone or decreasing excitation. However, this not shown human brain tissue. Many genetic means achieving channelrhodopsin expression possible humans, and vector-mediated methods susceptible to...
Introduction The natural history and optimal treatment of previously ruptured anterior communicating artery (ACOM) aneurysms that recur is unknown. This study looks at rates complications recurrences ACOM treated endovascularly surgically.Materials methods A retrospective observational all patients presenting to a single tertiary neurosurgical centre with the first presentation subarachnoid haemorrhage (SAH) secondary aneurysm. Data was collected from November 2012 September 2018 included...
Type II odontoid fractures are known to have low fusion rates following conservative management with a hard collar. However, most patients elderly comorbidities and not fit for surgery. The present study identified the of bony fusion, complications, clinical outcomes type fractures.We included consecutive referred suspected fracture Major Trauma Centre in UK between March 2015 December 2017. Data including patient demographics, management, complications outcomes. Bony was assessed by two...
Cervical disc arthroplasty is a treatment option for symptomatic cervical disease. There paucity of literature on long-term safety outcomes, durability, and device-related failure rates. The M6-C artificial device with titanium alloy endplates complex polymeric centerpiece. To date, trials have exhibited acceptable profiles.This case series describes the presentation, management, pathological findings delayed prevertebral periprosthetic mass anterior to disc. Four patients at 3 different...
Background There is very little reported in the literature about relationship between modifications of bacterial proteins and their secretion by mammalian cells that synthesize them. We previously enzyme Chondroitinase ABC requires strategic removal at least three N-glycosylation sites. The aim this study was to determine if it possible enhance efficacy as a treatment for spinal cord injury increasing quantity secreted or altering its cellular location. Methodology/Principal findings To...
In surgical skill assessment, Objective Structured Assessments of Technical Skills (OSATS scores) and the Global Rating Scale (GRS) are established tools for evaluating performance surgeons during training. These metrics, coupled with feedback on their performance, enable to improve achieve standards practice. Recent studies open-source dataset JIGSAW, which contains both GRS OSATS labels, have focused regressing scores from kinematic signals, video data, or a combination both. this paper,...
Objective: To illustrate our experience when managing a complex patient with potentially life-threatening bilateral otological disease facing multisensory compromise including complete loss of audiovestibular function and visual disturbanceClinical presentation: A 67 year old lady, presented large left vestibular schwannoma extensive right cholesteatoma encircling the otic capsule. She underwent translabyrinthine resection schwannoma, resulting in profound sensorineural hearing loss,...
Physical phantom models have been integral to surgical training, yet they lack realism and are unable replicate the presence of blood resulting from actions. Existing domain transfer methods aim enhance realism, but none facilitate simulation. This study investigates overlay on images acquired during endoscopic transsphenoidal pituitary surgery models. The process involves employing manual techniques using GIMP image manipulation application automated pythons Blend Modes module. We then...
Objectives Type 2 peg fractures are known to have low fusion rates but most elderly with comorbidities and not fit for surgery. Increasingly, clinicians want stop using hard collars due its complications, little supporting evidence. We aim provide data add this debate. Design Single centre cohort study. Subjects 145 consecutive patients referred a Major Trauma Centre as type fracture. Methods All suspected fracture between March 2015 December 2017 were included. imaging assessed case notes...
Introduction This study reviews the type, severity, management and follow-up of renal trauma presenting to a major centre in northwest England four years following inception centre. Given recent introduction centres nationally, research is needed within every specialty ensure that centralisation services benefits all patients affected by these changes. Methods Patients Aintree University Hospital with between June 2012 2016 were identified using Trauma Audit Research Network (TARN) database....
INTRODUCTION: The natural history and optimal treatment—of previously ruptured anterior communicating artery (ACOM) aneurysms that recur is unclear. This study determines whether our management decisions of endovascular treatment vs open surgery correct with respect to recurrence rebleeding rates. METHODS: A retrospective observational study. All patients presenting a single centre subarachnoid haemorrhage (SAH) secondary an ACOM aneurysm were included. Data was collected from November 2012...