A5101584955- Intraocular Surgery and Lenses
- Glaucoma and retinal disorders
- Ocular Surface and Contact Lens
- Corneal surgery and disorders
- Genetics and Neurodevelopmental Disorders
- Speech and Audio Processing
- Acoustic Wave Phenomena Research
- Ophthalmology and Visual Impairment Studies
- Anesthesia and Neurotoxicity Research
- Corneal Surgery and Treatments
- Noise Effects and Management
- Hydrogen's biological and therapeutic effects
- Hearing Loss and Rehabilitation
- Metabolism and Genetic Disorders
- Advanced Glycation End Products research
- Pharmacological Effects and Toxicity Studies
- Family and Disability Support Research
- Ocular Infections and Treatments
- Epilepsy research and treatment
- RNA regulation and disease
- Advanced Algorithms and Applications
- Nerve injury and regeneration
- Retinal and Macular Surgery
- Contact Dermatitis and Allergies
- Aerodynamics and Acoustics in Jet Flows
Suzuki (Japan)
2006-2025
Nippon Medical School
2010-2022
Chiba Hokusou Hospital
2022
Alcon (Japan)
2022
Nippon Medical School Musashi Kosugi Hospital
2012-2017
Nippon Dental University Hospital
2015
Christie's
2014
Ministry of Education, Culture, Sports, Science and Technology
2014
Kyushu University
2004-2010
Faculty of Design
2004-2007
Oesophageal adenocarcinoma is the sixth most common cause of cancer death worldwide and Barrett's oesophagus biggest risk factor. We aimed to evaluate efficacy high-dose esomeprazole proton-pump inhibitor (PPI) aspirin for improving outcomes in patients with oesophagus.
Retinal ischemia-reperfusion (I/R) injury by transient elevation of intraocular pressure (IOP) is known to induce neuronal damage through the generation reactive oxygen species. Study results have indicated that molecular hydrogen (H(2)) an efficient antioxidant gas selectively reduces hydroxyl radical (*OH) and suppresses oxidative stress-induced in several organs. This study was conducted explore neuroprotective effect H(2)-loaded eye drops on retinal I/R injury.Retinal ischemia induced...
Although tear hyperosmolarity is assumed to play a major role in dry eye disease, correlation between the level of and inflammation remains unclear. The purpose this study was examine effect short-time exposure production inflammatory cytokines corneal epithelial cells vitro.Human (HCE) were cultured under different osmotic conditions [310 (control), 400-1000 mOsm]. Lactate dehydrogenase (LDH) release after short-term (10 minutes) or long-term (24 hours) hyperosmotic stress evaluated...
Abstract In phacoemulsification, ultrasound induces hydroxyl radical (·OH) formation, damaging corneal endothelium. Whether H 2 can prevent such oxidative damage in phacoemulsification was examined by vitro and vivo studies. dissolved a commercial irrigating solution. The effects of against ·OH generation were first confirmed electron-spin resonance (ESR) hydroxyphenyl fluorescein (HPF). ESR showed significantly decreased signal magnitude fluorescence intensity oxidized HPF less the...
Hydrogen (H2) has been reported to scavenge free radicals, particularly the hydroxyl radical (·OH). Ultrasound oscillation in an aqueous solution produces ·OH. Our recent study demonstrated that H2 dissolved irrigation prevented corneal endothelial damage during phacoemulsification animal model. We examined effects of clinical phacoemulsification.A single-center, prospective, randomized, double-masked trial.Thirty-two patients who had cataracts similar nucleus hardness both eyes (age:...
Subacute sclerosing panencephalitis is caused by persistent brain infection of mutated measles virus, showing inflammation, neuronal loss, and demyelination. We neuropathologically examined six autopsy cases subacute panencephalitis, using in situ nick end-labeling immunohistochemistry. Both the neurons glial cells cerebral cortex showed immunoreactive nuclei two with disease duration within 2 years, whereas they were confined to demyelinated white matter three ranging from 10 years. The...
<title>Abstract</title> This study evaluated the posterior capsule elevation ratio after occlusion break in a porcine eye model of an eyelid speculum (ES) using Centurion Vision System with Active Sentry handpiece (AS). The mean intraocular pressure eyes ES was significantly higher than that without (15.42 ± 4.10 mmHg vs. 21.86 4.12 mmHg, P = 0.0003). Changes were observed slit side view method following four groups: AS [AS (ES+)], (ES−)], Ozil [OZ and OZ (ES−)]. Eleven each group tested....
To assess a new method of functional evaluation corneal endothelium using combined measurement volume alteration and cell density (CD) after phacoemulsification.Nippon Medical School Hospital, Tokyo, Japan.Phacoemulsification was performed in 28 cases. The within 3.0 mm 10.0 circles the cornea measured Scheimpflug imaging (Pentacam, Oculus, Inc.) density, specular microscopy (Noncon Robo, Konan Medical). stress index (VSI), parameter for measuring evaluation, calculated by dividing increase...
To directly measure intraocular pressure (IOP) in simulated phacoemulsification and to assess the usefulness of lowering bottle height protecting corneal endothelium clinical phacoemulsification.Nippon Medical School Hospital, Tokyo, Japan.Simulated was performed porcine eyes with 2 heights, 65.0 cm (BH 65 group) 19.0 19 group). The IOP continuously measured a microprobe. In study, 60.0 60 30.0 30 One day, 1 week, 3 months after surgery, cell density volumes were using specular microscopy...
To evaluate changes in the aqueous humor temperature using 2 phacoemulsification units (Stellaris 28.5 kHz device and Whitestar Signature 40 device).Nippon Medical School, Musashikosugi Hospital, Kawasaki City, Kanagawa, Japan.Experimental study.Aqueous temperatures were measured with a probe set anterior chamber during ultrasound (US) oscillation porcine eyes under 5 conditions.Continuous longitudinal caused rapid rise temperature, while pulse elliptical modes suppressed elevation. Reducing...
To investigate temperature alterations in the aqueous humor and corneal endothelium during phacoemulsification, to evaluate effect of ophthalmic viscosurgical devices preventing a rise at phacoemulsification.Temperatures were measured using two probes set anterior chamber ultrasound oscillation porcine eyes, with or without devices.Without an device, temperatures both rapidly rose oscillation, while elevation site was suppressed compared humor.Surgeons need be especially aware device...
Purpose: Because dry eye greatly reduces quality of life, this study aimed to examine rebamipide instillation in patients with and assess the improvement signs symptoms as evaluated Ocular Surface Disease Index, which is most popular index highly reliable. Methods: From June 2013 through January 2014, we examined 50 eyes 25 (6 men 19 woman) at our institution. Dry was diagnosed on basis presence symptoms, tear dynamics, ocular surface abnormalities according Japanese criteria for eye. Before...
Purpose Occupational musculoskeletal disorders are prevalent in ophthalmic surgeons and can impact surgeons’ well-being productivity. Heads-up displays may reduce ergonomic stress compared to conventional microscopes. This cross-sectional, non-interventional study experience between heads-up display ocular Methods The protocol was approved by the independent ethics committee nonprofit organization MINS Institutional Review Board. An online questionnaire distributed a sample of Japan with...
In this paper, we propose a simple method that considers boundary conditions in finite difference time domain (FDTD) scheme by varying density, sound speed and flow resistance. A based on Rayleigh model is also proposed, these methods, can design the frequency characteristics of normal incident absorption coefficient arbitrarily. These methods have three advantages: 1. easy coding, 2. designing characteristic 3. configuration material thickness. For example, our method, simulate field...
Objective: To examine the effects of rebamipide ophthalmic solution on symptoms, signs, and cytokine concentrations in tear fluid among soft contact lens (SCL) wearers with Dry eye disease (DED). Methods: From November 2015 to June 2017, this open-label, single-arm study examined 40 eyes 20 SCL DED who had been using daily disposable SCLs for >3 months (mean age, 30.0±8.33 years; range, 20–47 years). Signs, were assessed before 4 weeks after starting 2% times/day. was diagnosed according...
To determine the effect of ophthalmic viscosurgical devices (OVDs) and irrigation/aspiration (I/A) settings on free radical development during phacoemulsification.Department Ophthalmology, Nippon Medical School, Tokyo, Japan.Free radicals were detected by electron spin resonance (ESR) spin-trap method. After a spin-trapping agent, 5,5-dimethyl-1-pyrroline N-oxide 1%, was mixed with irrigating solution, phacoemulsification simulation performed in an eye model at 100% ultrasound power levels...
Positron emission tomography was performed on six patients with Rett syndrome to investigate cerebral blood flow and oxygen metabolism, the results were compared concurrent clinical status of patients. The metabolic rate (CMRO2) low in five patients, extraction fraction four patients; both had a tendency decline advancing age. Although cause is unknown, it suggested that impaired oxidative metabolism exists syndrome. An analysis distribution among brain regions showed ratios values for...
Purpose: The aim of this study was to measure serum levels brain-derived neurotrophic factor (BDNF) in Japanese patients with primary open angle glaucoma (POAG) and normal tension (NTG). Methods: This a prospective observational BDNF 78 who underwent cataract surgery or trabeculectomy (27 51 non-glaucoma as controls). Patient age 68.8 ± 11.1 years (mean standard deviation; range 35-86 years). numbers POAG NTG were 16 11, respectively. diagnosed by intraocular pressure measurement,...
The purpose of this study was to examine changes in the ocular surface before and after phacoemulsification with small incisions tear osmolarity.This a prospective, observational involving 55 eyes 39 patients (19 male, 20 female patients; average age 72.0±7.3 years) who had cataract surgery at Nippon Medical School Hospital between December 2013 June 2018. Compromised dynamics were determined by Schirmer test or break-up time (BUT). An abnormal identified positive vital staining fluorescein...
Purpose: To evaluate the responsiveness of 3 phacoemulsification and aspiration (PEA) systems a new handpiece to occlusion break by measuring anterior chamber depth (ACD) intraocular pressure (IOP). Setting: Zengyo Suzuki Eye Clinic, Kanagawa, Japan. Design: Experimental study. Methods: ACD change during intentional breaks was observed evaluated using slit side view (SSV) method IOP measurement with Centurion Vision System (Group 1), Active Sentry 2), Infiniti 3), Constellation 4). 5 eyes...
Purpose: To evaluate usefulness of a new semicircular capsulotomy marker in continuous curvilinear capsulorrhexis (CCC). Methods: In 20 eyes patients who underwent cataract surgery, newly designed with an internal diameter 5.5 mm was used to place circular mark directly on the lens capsule. The then as guide complete CCC set diameter. resultant size each case confirmed by analysis video image. Results: average 5.2 ± 0.3 mm. all cases, edge intraocular completely covered anterior Conclusion:...