A5002377776- Lung Cancer Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- COVID-19 Clinical Research Studies
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- Pleural and Pulmonary Diseases
- Immunotherapy and Immune Responses
- Cancer Diagnosis and Treatment
- RNA modifications and cancer
- Long-Term Effects of COVID-19
- Head and Neck Cancer Studies
- T-cell and B-cell Immunology
- Kidney Stones and Urolithiasis Treatments
- Bladder and Urothelial Cancer Treatments
- Immune Cell Function and Interaction
- Intensive Care Unit Cognitive Disorders
- Ureteral procedures and complications
- SARS-CoV-2 and COVID-19 Research
- Myasthenia Gravis and Thymoma
- Trauma Management and Diagnosis
- Salivary Gland Tumors Diagnosis and Treatment
- Genetic factors in colorectal cancer
- Central Venous Catheters and Hemodialysis
Harefield Hospital
2021-2025
Guy's and St Thomas' NHS Foundation Trust
2022-2025
Royal Brompton Hospital
2023-2024
St Thomas' Hospital
2024
Prefeitura Municipal de Alto Alegre
2024
Royal Brompton & Harefield NHS Foundation Trust
2017-2023
Imperial College London
2023
Roche (Switzerland)
2023
Boehringer Ingelheim (India)
2023
AstraZeneca (Brazil)
2023
BackgroundThere is limited randomized evidence on the comparative outcomes of early-stage lung cancer resection by video-assisted thoracoscopic surgery (VATS) versus open resection.MethodsWe conducted a parallel-group multicenter trial that recruited participants with known or suspected and randomly assigned them to VATS their lesions. The primary outcome was physical function at 5 weeks as measure recovery using European Organisation for Research Treatment Cancer core health-related quality...
Abstract The introduction of the International Association for Study Lung Cancer grading system has furthered interest in histopathological risk stratification lung adenocarcinoma. Complex morphology and high intratumoral heterogeneity present challenges to pathologists, prompting development artificial intelligence (AI) methods. Here we developed ANORAK (pyrAmid pooliNg crOss stReam Attention networK), encoding multiresolution inputs with an attention mechanism, delineate growth patterns...
8504 Background: Video assisted thoracoscopic surgery (VATS) is a popular access for lung cancer resection. However, there limited information from RCTs in-hospital to one-year clinical efficacy, safety and oncologic outcomes of minimal approach. Methods: VIOLET parallel group multi-center RCT conducted in 9 centers the United Kingdom that recruited participants with known or suspected (cT1-3, N0-1 M0) (ISRCTN13472721). Trial protocol: https://bmjopen.bmj.com/content/9/10/e029507.info....
The objectives of the current study were to develop an initial blood-based circulating tumor DNA (ctDNA) gene signature and validate clinical test performance in patients with early primary secondary lung cancer.Between January 2009 October 2014, a total 211 known or suspected cancer donated their blood prior surgery followed up May 2018. ctDNA was extracted from plasma corresponding formalin-fixed, paraffin-embedded tissues. analyzed blinded manner pathology reports issued that results....
Purpose The aim of this study is to validate the current applicability arteriovenous access banding in high flow (HFA) and/or haemodialysis access-induced distal ischaemia (HAIDI). Methods This retrospective was conducted at GEV (Grupo de Estudos Vasculares) vascular centre. clinical records consecutive patients undergoing for HAIDI and HFA symptoms, between June 2011 January 2015, were reviewed until April 2015. All patients’ consultation surgical notes reviewed. We analysed compared age,...
Advances in perioperative management for thoracic surgery have accelerated the postoperative recovery of patients by decreasing pain and incidence complications. We aimed to study whether it's safe remove chest drains on table selected cases.
Background: Chest drain management is a variable aspect of postoperative care in thoracic surgery, with different opinion for air and volume output. We aim to study if acceptable safety was maintained using leak criteria alone. Methods: A 9-year retrospective analysis protocolised chest digital cut off less than 20 mL/min more 6 h removal patients undergoing general surgery. excluded not required nor removed during admission or underwent reduction pneumonectomy. Withdrawal were suspected...
Objectives The aim of this study is to collate multi-institutional data determine the value by defining diagnostic performance fluorodeoxyglucose positron emission tomography (FDG PET)/CT for malignancy in patients undergoing surgery with an anterior mediastinal mass order ascertain clinical utility PET/CT differentiate malignant from benign aetiologies presenting Setting DECiMaL Study a multicentre, retrospective, collaborative cohort seven UK surgical sites. Participants Between January...
Background: Despite its importance in clinical practice, guideline pathway selection and as an outcome trials, little work has been undertaken to understand the agreement between expected lung function loss actual observed values. This is particular pertinent view of unexpected findings JCOG 0802 CALBG 140503 demonstrating no clinically meaningful difference sub-lobar resection lobectomy arm. Methods: We performed a retrospective analysis on preoperative postoperative forced expiratory...
Nighttime organ transplantation aims to decrease cold ischemia duration, yet conflicting data exists on its impact graft function and perioperative complications. This multicenter TRANSPLANT’AFUF study including 2,854 patients, transplanted between 1 January 2011, 31 December 2022, investigated nighttime kidney transplantation’s (8:00 p.m.–8:00 a.m.) versus daytime a.m.–8:00 p.m.) surgical complications survival. Overall, 2043 patients (71.6%) underwent graft, while 811 (28.4%) graft. No was...
Surgical mortality has traditionally been assessed at arbitrary intervals out to 1 year, without an agreed optimum time point. The aim of our study was investigate the time-varying risk death after lobectomy determine period evaluate surgical rate for lung cancer.
Abstract OBJECTIVES We sought to evaluate the impact of different national clinical guidelines (with consistent and conflicting recommendations) on clinician’s practice in UK. METHODS In this cohort study, we analysed data from National Lung Cancer Audit comprising all patients diagnosed with lung cancer between 2008 2013 within England Wales for (British Thoracic Society Institute Clinical Excellence) recommendations lower/more permissive function but opposing stage (N2) selection...
The aim of this study was to audit the results a high-dose, combined-modality prospective protocol for non-small-cell lung cancer in terms survival, disease-specific survival and toxicity. One hundred twenty-one patients with were treated concurrent, end-phase, boost, high-dose radiotherapy 65 Gy 35 fractions more than 5 weeks. Sixty-six received alone (group 1), 29 concurrent chemoradiation 2) 26 neoadjuvant chemotherapy 3). Thirty-four had stage I disease, six II 81 III. Overall median 23...
Surgical resection is the primary treatment for early-stage lung cancer, but little known about outcomes that truly matter to patients. This aim of our study was identify aspects postoperative most patients undergoing cancer surgery and explore influence clinical demographic factors on their importance ratings.
The construction of a shared global agenda represents one the main challenges for promotion sustainable world, requiring coordinated efforts between governments, institutions, civil society and individuals. prospects achieving this goal involve implementation effective public policies, encouraging technological innovation strengthening international cooperation, seeking integrated solutions to issues such as climate change, social inequality health. In context, Clinics Biopsychosocial...