A5000275974- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Colorectal Cancer Treatments and Studies
- Pancreatic and Hepatic Oncology Research
- Cancer Treatment and Pharmacology
- Cancer Genomics and Diagnostics
- Intraperitoneal and Appendiceal Malignancies
- Patient-Provider Communication in Healthcare
- Innovations in Medical Education
- Lung Cancer Research Studies
- Interprofessional Education and Collaboration
- PARP inhibition in cancer therapy
- Appendicitis Diagnosis and Management
- DNA Repair Mechanisms
- Neutropenia and Cancer Infections
- Palliative Care and End-of-Life Issues
- Endometrial and Cervical Cancer Treatments
- Cancer Immunotherapy and Biomarkers
- Cancer therapeutics and mechanisms
- Renal cell carcinoma treatment
- Empathy and Medical Education
- Bone health and treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
St George Hospital
2013-2024
Bond University
2023-2024
The University of Melbourne
2024
Deakin University
2023
Griffith University
2019-2021
UNSW Sydney
2006-2020
Cancer Institute of New South Wales
2020
Gold Coast Hospital
2020
St. George Hospital
1994-2019
Gold Coast Health
2019
The National Cancer Institute of Canada Clinical Trials Group CO.17 study showed that patients with advanced colorectal cancer had improved overall survival when cetuximab, an epidermal growth factor receptor-targeting antibody, was given in addition to best supportive care. We conducted a cost-effectiveness analysis using prospectively collected resource utilization and health utility data for the who received cetuximab plus care (N = 283) or alone 274).Direct medical were collected,...
To assess the prevalence of ROS1 rearrangements in a retrospective and prospective diagnostic Australian cohort evaluate effectiveness immunohistochemical screening.A 278 early stage lung adenocarcinomas an additional 104 non-small-cell cancer (NSCLC) cases referred for routine molecular testing were evaluated. immunohistochemistry (IHC) was performed (D4D6 clone, Cell Signaling Technology) on all as well fluorescence in-situ hybridization (FISH) using ZytoVision Abbott Molecular FISH...
Abstract Background Cytoreductive surgery (CRS) combined with perioperative intraperitoneal chemotherapy (PIC) has been used to treat pseudomyxoma peritonei. The aim of this prospective study was evaluate survival outcome and treatment-related prognostic markers in patients who underwent CRS PIC for peritonei from appendiceal mucinous neoplasms. Methods Survival data 12 clinicopathological variables were obtained prospectively 50 consecutive (23 men). Univariate analysis determine their...
Resistance to anti-cancer drugs (drug resistance) can be defined in the laboratory by amount of drug that is required produce a given level cell death response). Clinical resistance either as lack reduction size tumour following chemotherapy or occurrence clinical relapse after an initial 'positive' response anti-tumour treatment. Many studies samples do not directly measure (because it difficult perform functional assays on tissue); instead, key proteins genes are involved particular...
ABCB1 (adenosine triphosphate-binding cassette transporter B1) mediates cellular elimination of many chemotherapeutic agents including paclitaxel, which is commonly used to treat ovarian cancer. A significant association between common single nucleotide polymorphisms (SNPs) in and progression-free survival has been reported patients with Variable paclitaxel clearance due genotype specific differences activity cancer cells and/or normal tissues may underlie the association. Using cell-based...
Peritoneal dissemination of malignancy is usually considered incurable. The purpose the present study was to evaluate efficacy intraperitoneal chemohyperthermia and cytoreductive surgery.The article a retrospective review prospectively recorded data in 60 patients who underwent 71 peritonectomy procedures between January 1996 May 2004. Hospital records, database department notes were studied. Conditions treated pseudomyxoma peritoneii (PMP) appendiceal cancer (23), mesothelioma (7),...
Vascular endothelial growth factor (VEGF) is the key molecule mediating tumor and malignant ascites formation. We recently reported that, in an end stage OVCAR-3 xenograft model, albendazole (ABZ) suppresses formation, but not growth. Hence, present study, we assessed effect of ABZ on vitro cell proliferation plus vivo growth, however, initiating treatment at mid (3 weeks post inoculation) rather than disease. Here, led to potent inhibition proliferation, VEGF suppression, complete formation...
Psychosocial interventions directed to couples where one has advanced cancer can reduce distress, enhance communication, and provide an opportunity for relational growth. The present study aimed develop intervention facilitate communication about living with using the Patient Dignity Inventory (PDI) as focus of a clinical interview toward end life.Couples were recruited from oncology palliative care services at Sydney hospital. After PDI was developed manualized couples, PDI-Couple Interview...
What is already known about this subject • Gemcitabine an anticancer drug which metabolized to a number of metabolites, administered using different dosing regimens and increasingly used in combination with oxaliplatin. The impact strategies therapy on the pharmacokinetics gemcitabine its main metabolite not clearly understood. study adds This has characterized people cancer, including variability between patients occasions. (but gemcitabine) were significantly affected by co‐administration...
Competency based medical education (CBME) has become the default for undergraduate and post-graduate (PGME) but its role in continuing professional development (CPD) is under discussion. Some critical differences between CPD PGME are identified these applied to: relative roles of competence performance; existing criticisms CBME; heutagogy as a learning theory; post-modernism an underlying philosophical perspective. The argument made that characteristics fit with performance education,...
Abstract Tumor-associated urokinase plasminogen activator (uPA) is a critical marker of invasion and metastasis, has strong prognostic relevance, thus potential therapeutic target. Experimental data published to date established the proof-of-principle uPA targeting by 213Bi-labeled inhibitor type 2 (α-PAI-2) in multiple carcinoma models. Here, we present preclinical toxicologic efficacy assessment α-PAI-2 mice, using both single multiple-dose schedules, administered an i.p. route. We also...
e19048 Background: AMG 655 is an investigational, fully human IgG1 monoclonal agonist antibody that binds death receptor 5 (DR5), activates caspases, and induces apoptosis in sensitive tumor cells. The primary objective of this phase 1b study was to determine the maximum tolerated dose (up a target 15 mg/kg) can be safely administered with PC. Methods: Eligibility included: ≥ 18-years old, untreated, advanced NSCLC, ECOG PS 0 or 1. Patients (pts) were enrolled sequential cohorts (5 + P (200...
Purpose Controversy exists over the optimal dose rate for administration of gemcitabine. There is a strong pharmacologic rationale increased intracellular accumulation with prolonged infusions, but this failed to translate into significant benefit in large randomized study. The purpose study was compare pharmacokinetics gemcitabine given 30 minutes or 100 crossover design. Patients and Methods We randomly assigned 33 patients standard 1,000 mg/m 2 either minutes. At second week, they were...