A5036678631- Cancer survivorship and care
- Melanoma and MAPK Pathways
- Patient-Provider Communication in Healthcare
- Colorectal Cancer Treatments and Studies
- Genetic factors in colorectal cancer
- Interprofessional Education and Collaboration
- Palliative Care and End-of-Life Issues
- Economic and Financial Impacts of Cancer
- Colorectal Cancer Surgical Treatments
- PI3K/AKT/mTOR signaling in cancer
- Colorectal Cancer Screening and Detection
- Health Systems, Economic Evaluations, Quality of Life
- Mental Health and Patient Involvement
- Lung Cancer Treatments and Mutations
- Advances in Oncology and Radiotherapy
- BRCA gene mutations in cancer
- Interpreting and Communication in Healthcare
- HIV-related health complications and treatments
- Advancements in Semiconductor Devices and Circuit Design
- Dialysis and Renal Disease Management
- Clinical practice guidelines implementation
- Colorectal and Anal Carcinomas
- Body Image and Dysmorphia Studies
- Cancer Treatment and Pharmacology
- Cancer-related cognitive impairment studies
Prince of Wales Hospital
2015-2025
South Eastern Sydney Local Health District
2019-2025
UNSW Sydney
2009-2024
Cancer Services
2024
Arena Pharmaceuticals (United States)
2020
Sir Charles Gairdner Hospital
2019
New South Wales Department of Health
2019
Cabrini Hospital
2016
Research Network (United States)
2015
Prince of Wales Hospital
2015
BACKGROUND. HIV/AIDS mortality rates in the United States are declining; pediatric HIV has become a chronic disease, with quality of life (QoL) outcomes assuming greater importance. OBJECTIVES. To compare QoL among HIV-infected and uninfected children to assess impact different antiretroviral regimens on children. METHODS. Perinatally exposed, (N = 1847) 712) adolescents were studied. Among infected children, 1283 available for regimen analysis. domain scores assessed subjects 6 months 4...
Abstract Purpose: Dabrafenib is a selective, potent ATP-competitive inhibitor of the BRAFV600-mutant kinase that has demonstrated efficacy in clinical trials. We report rationale for dose selection first-in-human study dabrafenib, including pharmacokinetics, tissue pharmacodynamics, 2[18F]fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) and dose–response relationship. Experimental Design: was administered orally once, twice (BID), or three times daily (TID). Selected cohorts...
The rising incidence of cancer and increasing number survivors place competing demands on specialist oncology clinics. This has led to a need consider collaborative care between primary secondary for the long-term post-treatment survivors.To explore views breast colorectal survivors, their oncologist GP about GPs taking more active role in follow-up care.Semi-structured interviews using thematic analysis framework. Respondents were asked hospital-based model greater or leading care....
Patients undergoing surgery for bowel cancer now have a routine screening test to assess their genetic predisposition this and other cancers (Lynch syndrome). A result indicating high risk should trigger referral clinic diagnostic testing, information, management. Appropriate management of Lynch syndrome lowers morbidity mortality from patients family, but rates are low. The aim project was increase at two Australian hospitals, using the Theoretical Domains Framework (TDF) Implementation...
People from ethnic minority backgrounds are exposed to greater risk of patient safety events (such as healthcare-acquired infections and medication errors) occurring in their healthcare. However, evidence the type frequency cancer care among patients background is lacking. This study sought address this gap. A two-stage retrospective medical record review was conducted at four services two Australian states. Eligible records each service that were identified belonging reviewed by clinician...
Somatic mutations in key oncogenes non-small cell lung cancer (NSCLC) and melanoma are important determinants of tumour sensitivity to targeted therapies. Molecular screening for these predictive biomarkers is routinely used inform treatment decisions; however, little known about how best communicate testing results patients. This qualitative study aimed explore advanced patients' attitudes experiences regarding somatic identify their information support needs. Sixteen NSCLC eight patients...
This study reports on the process of using an adapted Experienced-Based Co-Design (EBCD) conducted with culturally and linguistically diverse (CALD) consumers cancer service staff to co-design novel ‘Making it Meaningful’(MiM) instrument at a in Australia. Multi-source experiential contextual information was gathered phase 1 this evidence, coupled knowledge via feedback event used inform three workshops 2. A series meetings were prior between workshops. Theory progressively integrated into...
Plasma cystatin C (pCysC) may be superior to serum creatinine (sCr) as a surrogate of GFR. However, the performance pCysC for diagnosing acute kidney injury (AKI) after cisplatin-based chemotherapy is potentially affected by accompanying corticosteroid anti-emetic therapy and hydration.In prospective observational study pCysC, sCr, urinary molecule-1 (KIM-1), clusterin were measured over 2 weeks in 27 patients given first-cycle chemotherapy. The same variables Sprague-Dawley rats single...
Introduction Consumer engagement is central to high-quality cancer service delivery and a recognised strategy minimise healthcare-associated harm. Strategies developed enhance consumer specifically in relation preventing healthcare harm include questioning health professionals, raising concerns about possible mistakes or risks care encouraging patients caregivers report suspected errors. Patients from ethnic minority backgrounds are particularly vulnerable unsafe care, but current strategies...
Prostate cancer is a commonly diagnosed and treated malignancy, although it rarely presents with cutaneous metastases. In this case presentation, we describe the diagnosis treatment radiotherapy of patient who presented metastases on his chest wall secondary to prostate cancer. 2006, 73-year-old Caucasian gentleman metastatic castration resistant mitoxantrone prednisolone nodules wall. A punch biopsy metastases, histological confirmation positive staining for cytokeratin, PSA (prostate...
Abstract Background. Testing for mismatch repair (MMR) status in colorectal cancer (CRC) may provide useful prognostic and predictive information. We evaluated the impact of such testing on real-world practice regarding adjuvant chemotherapy patients with resected CRC. Patients Methods. A total 175 stage II III repair-deficient (MMRD) CRC were identified from an Australian population-based study incident CRCs. Their treatment decisions compared those a cohort 773 stage-matched...
Lynch syndrome is an inherited disorder associated with a range of cancers, and found in 2–5 % colorectal cancers. diagnosed through combination significant family clinical history pathology. The definitive diagnostic germline test requires formal patient consent after genetic counselling. If early, carriers can undergo increased surveillance for which turn prevent late stage optimise treatment decrease mortality themselves their relatives. However, over the past decade, international...
To investigate the factors that affect choice of 5-fluorouracil (5-FU) or its oral alternative, capecitabine, as first-line treatment in patients with colorectal cancer (CRC).Patients treated 5-FU capecitabine for CRC between January 1, 2011 and December 31, 2013 a teaching hospital Sydney metropolitan area, Australia were identified using hospital's database MOSAIQ®. The electronic medical record each patient was manually reviewed to extract potentially affecting choice. Logistic regression...
Objective: This paper describes the process of developing a shared cancer care approach in follow-up, and identifies e-health options that support an interactive e-care plan between public service, general practitioners (GPs) survivors.Type program/service: The service improvement initiative for follow-up targets colorectal patients who have completed active treatment agree to specialists, GPs other team members.The intiative is supported by agreed pathway dynamic, can be has functionalities...
Follicular dendritic cell sarcoma is a rare tumour with clinical behaviour covering spectrum from indolent to aggressive disease. Treatment recommendations are currently based on case reports and small series describing combinations of surgery, chemotherapy radiotherapy providing the best patient outcomes. Recent knowledge molecular aberrations in this disease have not yet impacted therapeutic decisions. We describe progressive follicular lung pleura, treated tumour’s aberrations. The was...
Treatment responses of BRAF mutant melanoma to inhibitors are often limited by the development resistance. This case report describes use multiplatform molecular profiling in sequential surgical samples a treatment-resistant tumour site subjected ongoing treatment with dabrafenib patient metastatic cutaneous melanoma. Next-generation sequencing showed presence V600E, fibroblast growth factor receptor 2 (FGFR2), phosphatase and tensin homologue (PTEN) p53 gene mutations. With continuous FGFR2...
Leptomeningeal disease (LMD) in epidermal growth factor receptor (EGFR)-mutant lung adenocarcinoma is associated with a poor prognosis and limited treatment options. Osimertinib potent third-generation EGFR tyrosine kinase inhibitor confirmed CNS penetration. This study reports on outcomes of patients EGFR-mutated non-small-cell cancer who developed LMD were subsequently treated osimertinib.We identified osimertinib 80 mg PO daily under compassionate access scheme across nine tertiary...
Co-design is increasingly employed as a user-centric method to create healthcare change. In co-design, small groups of consumers and workers come together identify processes, policies or service elements that require improvement design solutions. Multiple frameworks have emerged guide the health work force researchers how conduct co-design support consumer members engage in process effectively. Frameworks sought address propensity for exacerbate inequities with complex care needs...
Abstract Background Shared care is the preferred model for long-term survivorship by cancer survivors, general practitioners and specialists. However, remains specialist-led. A risk-stratified approach has been proposed to select suitable patients shared after survivors have completed adjuvant treatment. This study aims use patient scenarios explore views on suitability colorectal across risk spectrum from Methods Participants a brief questionnaire assessing demographics clinical issues...
In this article we present a narrative approach to conceptualizing and representing patients' experiences of healthcare across trajectory care. We empirically investigate, analyze represent the diagnostic care trajectories people with aggressive skin cancer melanoma, conceiving model lived narratives in which patients are central characters moving through longitudinal series events. Melanoma is malignant form that makes heavy, long-term demands on resources. The perspectives melanoma...
9571 Background: Cancer related fatigue is prevalent and disabling. When persistent unexplained, it termed post-cancer (PCF). Cognitive behavioural therapy (CBT) graded exercise (GET) may improve symptoms functional outcomes. Methods: A randomised control trial - Treatment of Post-cancer Study (TOPS) assigned patients to an education intervention, or a 12 week integrated CBT GET intervention supervised by physiologist clinical psychologist. Three months post treatment for breast colon...