A5023858011- Acute Kidney Injury Research
- Chronic Kidney Disease and Diabetes
- Dialysis and Renal Disease Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Muscle and Compartmental Disorders
- Advanced MRI Techniques and Applications
- Renal function and acid-base balance
- Cardiac Ischemia and Reperfusion
- Sepsis Diagnosis and Treatment
- Renal Transplantation Outcomes and Treatments
- Cardiac Arrest and Resuscitation
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Renal and Vascular Pathologies
- Metabolism and Genetic Disorders
- Medical Research and Treatments
- Organ Donation and Transplantation
- Hemodynamic Monitoring and Therapy
- Erythropoietin and Anemia Treatment
- MRI in cancer diagnosis
- Poisoning and overdose treatments
- Central Venous Catheters and Hemodialysis
- Drug-Induced Hepatotoxicity and Protection
- Liver Disease and Transplantation
- Blood Pressure and Hypertension Studies
UNSW Sydney
2016-2025
Prince of Wales Hospital
2016-2025
University of Otago
2011-2022
Kidney Health Australia
2020-2022
The University of Queensland
2001-2022
Royal Adelaide Hospital
2022
University of Alberta
1995-2022
Alberta Health Services
2022
Christ University
2017-2020
National Heart Foundation of New Zealand
2020
In 2012, Kidney Disease: Improving Global Outcomes (KDIGO) published a guideline on the classification and management of acute kidney injury (AKI). The was derived from evidence available through February 2011. Since then, new has emerged that important implications for clinical practice in diagnosing managing AKI. April 2019, KDIGO held controversies conference entitled Acute Injury with following goals: determine best practices areas uncertainty treating AKI; review key relevant literature...
Fibrosis leads to chronic impairment of cardiac and renal function thus reversal existing fibrosis may improve survival. This project has determined whether pirfenidone, a new antifibrotic compound, spironolactone, an aldosterone antagonist, reverse both deposition the major extracellular matrix proteins, collagen fibronectin, functional changes in streptozotocin(STZ)-diabetic rat. Streptozotocin (65 mg kg(-1) i.v.)-treated rats given pirfenidone (5-methyl-1-phenyl-2-[1H]-pyridone;...
Pre-renal acute kidney injury (AKI) is assumed to represent a physiological response underperfusion. Its diagnosis retrospective after transient rise in plasma creatinine, usually associated with evidence of altered tubular transport, particularly that sodium. In order test whether pre-renal AKI reversible because less severe than sustained AKI, we measured urinary biomarkers (cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), γ-glutamyl transpeptidase, IL-18, and molecule-1...
Background. Plasma cystatin C (pCysC) has been proposed as an alternative to plasma creatinine (pCr) a measure of renal function. We compared the detection functional change by both biomarkers in critically ill patients.
Summary New tests should improve the diagnostic performance of available tests. The area under receiver operator characteristic curve has been “metric choice” to quantify new biomarker performance. Two metrics, integrated discrimination improvement (IDI) and net reclassification (NRI), have rapidly adopted added value a an existing test. These metrics require development risk prediction models that calculate probability event for each individual. This study demonstrates application these in...
The concentration of urine influences the urinary biomarkers AKI. Whether normalization to creatinine concentration, as commonly performed quantitate albuminuria, is best method account for variations in biomarker among patients intensive care unit unknown. Here, we compared diagnostic and prognostic performance three methods quantitation: absolute normalized excretion rate. We measured concentrations alkaline phosphatase, γ-glutamyl transpeptidase, cystatin C, neutrophil...
Background and objectives: The purpose of this study was to assess the viability back-calculation with Modification Diet in Renal Disease (MDRD) formula determine baseline creatinine on basis acute kidney injury (AKI) metrics, RIFLE criteria, Acute Kidney Injury Network (AKIN) criteria for clinical trial outcomes or epidemiology. Design, setting, participants, & measurements: This a retrospective analysis prospectively collected data from patients measured creatinines before entry intensive...
To evaluate the utility of urinary cystatin C (uCysC) as a diagnostic marker acute kidney injury (AKI) and sepsis, predictor mortality in critically ill patients. This was two-center, prospective AKI observational study post hoc sepsis subgroup analysis 444 general intensive care unit (ICU) uCysC plasma creatinine were measured at entry to ICU. defined 50% or 0.3-mg/dL increase above baseline. Sepsis clinically. Mortality data collected up 30 days. The predictive performances assessed from...
Abstract Introduction The urine output criterion of 0.5 ml/kg/hour for 6 hours acute kidney injury (AKI) has not been prospectively validated. Urine criteria AKI (AKI UO ) as predictors in-hospital mortality or dialysis need were compared. Methods All admissions to a general ICU screened 12 months and hourly analysed in collection intervals between 1 hours. Prediction the composite by was increments 0.1 from optimal threshold each interval determined. Cr defined an increase plasma creatinine...
Acute kidney injury (AKI) is a common but complex clinical syndrome with multiple etiologies. These etiologies target different sites and pathways within the kidney. Novel biomarkers of 'kidney damage' (which can be tubular or glomerular) used to diagnose AKI, even in absence an increase serum creatinine oliguria. damage combined function facilitate classification AKI. A comprehensive review literature was performed using published methodology Dialysis Quality Initiative (ADQI) working group...
Detection of acute kidney injury is undergoing a dynamic revolution biomarker technology allowing greater, earlier, and more accurate determination diagnosis, prognosis, with powerful implication for management. Biomarkers can be broadly considered as any measurable biologic entity or process that allows differentiation between normal function disease. The ADQI (Acute Dialysis Quality Initiative) had its Ninth Consensus Conference dedicated to synthesis formulation the existing literature on...