A5039055117- Dialysis and Renal Disease Management
- Potassium and Related Disorders
- Renal Transplantation Outcomes and Treatments
- Metabolism and Genetic Disorders
- Gastrointestinal motility and disorders
- Blood Pressure and Hypertension Studies
- Chronic Kidney Disease and Diabetes
- Organ Transplantation Techniques and Outcomes
- Erythropoietin and Anemia Treatment
- Cardiovascular Health and Disease Prevention
- Renal function and acid-base balance
- Antibiotics Pharmacokinetics and Efficacy
- Diet and metabolism studies
- Atrial Fibrillation Management and Outcomes
- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
- Magnesium in Health and Disease
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- Mitochondrial Function and Pathology
- Hormonal Regulation and Hypertension
- Gastroesophageal reflux and treatments
- Neurological and metabolic disorders
- Vitamin K Research Studies
- Hemoglobinopathies and Related Disorders
Onze Lieve Vrouwziekenhuis Hospital
2008-2022
Pediatric Nephrology of Alabama
2019
Vilnius University
2010
Wroclaw Medical University
2010
University of Wrocław
2010
University of San Diego
2008
Ghent University Hospital
1996-2007
University of Michigan
2004
Ghent University
2000-2002
Geneeskundige en Gezondheidsdienst
2001
Significance Statement Functional vitamin K deficiency, exacerbated by the use of antagonists (VKAs), is thought to contribute rapid progression vascular calcifications in patients on dialysis. We randomized receiving chronic hemodialysis with atrial fibrillation VKAs, rivaroxaban, or rivaroxaban high-dose K2 supplements. During 18 months follow-up, status improved significantly withdrawal VKAs and supplementation. Nevertheless, changes coronary artery, thoracic aorta, cardiac valve calcium...
Haemodialysis patients suffer from accelerated vascular calcification. The vitamin K-dependent matrix Gla protein (MGP) is one of the most powerful inhibitors have high levels inactive form MGP (desphosphorylated-uncarboxylated-MGP, dp-uc-MGP) and may benefit pharmacological doses K2 (menaquinone) to improve calcification inhibitory activity MGP. To determine optimal dose menaquinone-7 (MK-7) for activation, 200 chronic haemodialysis were recruited randomly receive 360, 720 or 1080 µg MK-7...
Preliminary evidence suggests patients on hemodialysis have a blunted early serological response to SARS-CoV-2 vaccination. Optimizing the vaccination strategy in this population requires thorough understanding of predictors and dynamics humoral cellular immune responses different vaccines.This prospective multicenter study 543 75 healthy volunteers evaluated at 4 or 5 weeks 8 9 after administration BNT162b2 mRNA-1273 vaccine, respectively. We assessed anti-SARS-CoV-2 spike antibodies T cell...
Abstract Background: Uremic syndrome is the consequence of retention solutes usually cleared by healthy kidneys. p-Cresol can be considered a prototypic protein-bound uremic toxin. It conceivable, analogous with drugs, that non-protein-bound fraction p-cresol exerts toxicity. This aspect had never been evaluated, nor have factors influencing free p-cresol. Methods: In transsectional study we evaluated relationship between prehemodialysis and ratio to total (F:T) clinical biological in 44...
In previous studies on the effect of renal stenting arterial hypertension, patients were selected mainly basis angiographic parameters artery stenosis. The aim present study was to evaluate whether translesional pressure gradients could identify with stenosis who might benefit from stenting.A total 53 consecutive hypertensive unilateral RAS scheduled for intervention recruited. Transstenotic measured at baseline and during maximal hyperemia, before stenting. Twenty-four-hour ambulatory blood...
Acute renal failure after cardiac surgery increases in-hospital mortality. We evaluated the effect of intra- and postoperative tight control blood glucose levels on function based Risk, Injury, Failure, Loss, End-stage kidney (RIFLE) criteria, need for acute dialysis. retrospectively analyzed two groups consecutive patients undergoing with cardiopulmonary bypass between August 2004 June 2006. In first group, no glycemic was implemented (Control, n = 305). Insulin therapy initiated at > 150...
Background. Several studies with erythropoiesis-stimulating agents claim that maintenance therapy of renal anaemia may be possible at extended dosing intervals; however, few were randomized, results varied, and comparisons between absent. We report a multi-national, prospective trial comparing haemoglobin methoxy polyethylene glycol-epoetin beta darbepoetin alfa administered once monthly.
Background. Extending the administration interval of erythropoiesis-stimulating agents (ESAs) represents an opportunity to improve efficiency anaemia management in patients with chronic kidney disease (CKD). However, effective haemoglobin (Hb) maintenance can be challenging epoetin alfa and beta administered at extended intervals. C.E.R.A., a continuous erythropoietin receptor activator, has unique pharmacologic profile long half-life (∼130 h), allowing Phase III results have demonstrated...
In clinical practice, glomerular filtration rate (GFR) is the most important marker for evaluation of renal function (1). Dosages drugs that are eliminated by often based on GFR. At present, reliable methods accurate assessment overall GFR require intravenous administration exogenous compounds and both cumbersome expensive. creatinine clearance (CrCl) widely accepted as a simple measure However, CrCl systematically overestimates because freely filtered glomerulus also secreted proximal...
Finerenone, a selective nonsteroidal MRA, and SGLT2is both reduce CKD progression improve kidney/CV outcomes. The CONFIDENCE study (NCT05254002; EudraCT 2021-003037-11) hypothesis is that early combination of finerenone empagliflozin, SGLT2i, superior to either drug alone in reducing UACR over 6 months. an ongoing, fully enrolled, randomized, controlled, double-blind, multicentre phase 2 clinical trial adults (≥18 years age) with T2D, eGFR 30 90 ml/min/1.73 m2, ≥100 <5000 mg/g. Participants...
Many patients with chronic renal failure have dyspeptic symptoms. In the present study, we assessed Helicobacter pylori (Hp) status, symptoms and gastric emptying rates in uremic patients. The study was undertaken to compare not under dialysis therapy (predialysis), hemodialysis (HD) peritoneal (PD) for these variables search a possible causative role of Hp.We used standardized questionnaire assess Gastric were determined by 13C-octanoic acid breath test. HD examined outside session, PD...
C.E.R.A., a continuous erythropoietin receptor activator, is long-acting erythropoiesis-stimulating agent (ESA) that approved for the treatment of renal anemia. This analysis evaluated safety profile C.E.R.A. in comparison to other ESAs patients with chronic kidney disease (CKD).Safety parameters were analyzed pooled population comprising all CKD on dialysis and not from completed Phase II III studies clinical program (Phase II/III population); treated either (n = 1,789) or comparator ESA...
Introduction A delay in gastric emptying rate has been reported peritoneal dialysis patients, often normalizing after evacuation of the dialysate. To evaluate effect intraperitoneal volume, we compared this finding with a cirrhotic model which was studied before and large-volume paracentesis. Methods design We used 13C-octanoic acid breath test to measure half-emptying time (T1/2) for solids patients alcoholic cirrhosis, non-diabetic control population (asymptomatic volunteers). Cirrhotic...
BACKGROUND:Hypomagnesemia is associated with a disturbed glucose metabolism. Insulin hypo-secretion predicts diabetes in the general population and transplant recipients. We aimed to assess whether magnesium improves insulin secretion glycemic control after transplantation prevalent hypomagnesemic kidney MATERIAL AND METHODS:We conducted an open-label, randomized, parallel-group study. Eligible participants were adults more than 4 months on tacrolimus persisting serum concentrations <1.8...
Enterococcus cecorum was isolated as the etiologic agent of a continuous ambulatory peritoneal dialysis peritonitis episode in an alcoholic patient. To date, this is only third infection due to bacterium, found intestinal tract many domestic animals, that has been reported humans.
Currently available rat models for measuring gastric emptying are hampered by the necessity to kill animals at end of each experiment, which makes repetitive testing impossible. We have developed and validated a noninvasive test model, adapted from 13C-octanoic breath in humans, measurements rats. Male Wistar rats were trained on fixed protocol eat piece pancake doped with 1 microg acid after 12 h fasting, stay thereafter cylindrical glass cages. Breath tests performed fully automated system...
Increasing evidence indicates that lipophilic and/or protein-bound substances such as p-cresol are responsible for adverse physiological alterations in uraemic patients. To better understand the evolution of disposition renal failure and dialysis patients, it is necessary to determine its kinetic characteristics biotransformation pathways.We studied after intravenous injection compound eight rats with normal function. Urine was collected four 1 h intervals. evaluate presence metabolites,...