A5002239035- RNA modifications and cancer
- Genomics and Phylogenetic Studies
- Acute Myeloid Leukemia Research
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Hemiptera Insect Studies
- Viral gastroenteritis research and epidemiology
- Insect and Arachnid Ecology and Behavior
- Cancer Genomics and Diagnostics
- Insect Resistance and Genetics
- RNA Research and Splicing
- Bioinformatics and Genomic Networks
- Animal Virus Infections Studies
- Escherichia coli research studies
- Hydraulic and Pneumatic Systems
- Cell death mechanisms and regulation
- Birth, Development, and Health
- Analytical Chemistry and Chromatography
- RNA and protein synthesis mechanisms
- Bacterial Genetics and Biotechnology
- Hemoglobinopathies and Related Disorders
- Genetic Associations and Epidemiology
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Aquaculture disease management and microbiota
- Bone Metabolism and Diseases
Zhoukou Normal University
2022-2025
University of Illinois Urbana-Champaign
2024-2025
University of Illinois Chicago
2022-2025
Zhejiang Sci-Tech University
2025
Tianjin Economic-Technological Development Area
2018-2024
Nankai University
2018-2024
Wenzhou Medical University
2024
Zhejiang Cancer Hospital
2024
Children's Hospital of Philadelphia
2020-2024
Guiyang Medical University
2023-2024
To evaluate the efficacy and safety of dulanermin combined with paclitaxel carboplatin (PC) bevacizumab (PCB) as first-line treatment for advanced or recurrent non-small-cell lung cancer (NSCLC).Patients squamous NSCLC and/or CNS metastases received PC every 3 weeks alone (arm 1) 8 mg/kg 5 days 2). Patients nonsquamous PCB 3) 4) 20 2 5). The primary end point was objective response rate (ORR).Overall, 213 patients were randomly assigned 1, n = 41; arm 2, 39; 3, 42; 4, 40; 5, 41). ORR in arms...
Significance We have identified a lethal subtype of gastric cancer (GC) that is characterized by high levels clonal heterogeneity and TP53 (tumor protein P53) mutation. also uncovered key novel mutations in the targetable NRG1 (neuregulin-1) ERBB4 (V-Erb-B2 avian erythroblastic leukemia viral oncogene homolog 4) ligand-receptor pair BRCA2 (breast 2, early onset) as new genetic markers to predict better survival for GC. Our study represents approach GC personalized medicine clinical...
Abstract Purpose: With a widening arsenal of cancer therapies available, it is important to develop therapy-specific predictive markers and methods rapidly assess treatment efficacy. We here evaluated the use cytokeratin-18 (CK18) as serum biomarker for monitoring chemotherapy-induced cell death in breast cancer. Experimental Design: Different molecular forms CK18 (caspase cleaved total) were assessed by specific ELISA assays. Drug-induced release was examined from carcinoma cells tissue....
BioXpress is a gene expression and cancer association database in which the levels are mapped to genes using RNA-seq data obtained from The Cancer Genome Atlas, International Consortium, Expression Atlas publications. includes 64 types, 6361 patients 17 469 with 9513 of displaying differential between tumor normal samples. In addition directly retrieved repositories, manual biocuration publications supplements available annotations database. All types Disease Ontology terms facilitate...
Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe
Inflammatory bowel disease (IBD) is a chronic and refractory condition characterized by disrupted epithelial barrier, dysregulated immune balance, altered gut microbiota. Nano-enabled interventions for restoring homeostasis have the potential to alleviate inflammation in IBD. Herein, we developed combination of olsalazine (Olsa)-based nanoneedles microbiota-regulating inulin gel reshape intestinal relieve inflammation. The Olsa-derived exhibited reactive oxygen species scavenging ability...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) binds to death receptors 4 and 5 (DR4, DR5) transduce apoptotic signals. Conatumumab (AMG 655) is an investigational, fully human monoclonal agonist antibody (IgG1) DR5, which induces apoptosis via caspase activation. In this study, we demonstrate that conatumumab activating intracellular caspases in vitro the presence of a cross-linker. We also show has activity vivo inhibits tumor growth colon (Colo205 HCT-15), lung (H2122),...
As a global regulator, RpoN controls wide range of biological pathways, including virulence in P. aeruginosa PAO1. This work shows that plays critical and roles the regulation bacterial pathogenicity fitness. ChIP-seq provided useful database to characterize additional functions targets future. The functional characterization RpoN-mediated will improve current understanding regulatory network quorum sensing other bacteria.
The High-performance Integrated Virtual Environment (HIVE) is a distributed storage and compute environment designed primarily to handle next-generation sequencing (NGS) data. This multicomponent cloud infrastructure provides secure web access for authorized users deposit, retrieve, annotate on NGS data, analyse the outcomes using interface visual environments appropriately built in collaboration with research regulatory scientists other end users. Unlike many massively parallel computing...
We sought to define the landscape of alternative pre-mRNA splicing in prostate cancers and relationship exon choice known cancer driver alterations. To do so, we compiled a metadataset composed 876 RNA-sequencing (RNA-Seq) samples from five publicly available sources representing range phenotypes normal tissue drug-resistant metastases. subjected these exon-level analysis with rMATS-turbo, purpose-built software designed for large-scale analyses splicing, identified 13,149 high-confidence...
Years of sequence feature curation by UniProtKB/Swiss-Prot, PIR-PSD, NCBI-CDD, RefSeq and other database biocurators has led to a rich repository information on functional sites genes proteins. This along with variation-related annotation can be used scan human short reads from next-generation sequencing (NGS) pipelines for presence non-synonymous single-nucleotide variations (nsSNVs) that affect sites. similar workflows are becoming more important because thousands NGS data sets being made...
BACKGROUND In patients with previously untreated metastatic colorectal cancer (mCRC), we conducted a phase 1b/randomized 2 trial to define the safety, tolerability, and efficacy of mFOLFOX6 plus bevacizumab (mFOLFOX6/bev) conatumumab, an investigational, fully human monoclonal IgG1 antibody that specifically activates death receptor 5 (DR5). METHODS Twelve were enrolled in 1b open‐label dose‐escalation conatumumab mFOLFOX6/bev; thereafter, 190 randomized 1:1:1 receive mFOLFOX6/bev...
Highlights•Osteoprotegerin (OPG) is the endogenous inhibitor of Receptor Activator NF-κB Ligand (RANKL)•RANKL has been shown to be crucially important in progesterone-mediated breast carcinogenesis•Serum OPG regulated by progesterone and low BRCA1/2 mutation carriers•Low serum associated with increased proliferation mammary gland•Antiprogestogens or anti-RANKL antibody (denosumab) may new strategies for cancer prevention carriers.Preventing deadly cancers a high priority 21st century...