A5045823606- Pharmaceutical Practices and Patient Outcomes
- Musculoskeletal pain and rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Pharmacogenetics and Drug Metabolism
- Antibiotics Pharmacokinetics and Efficacy
- Pharmaceutical studies and practices
- Pain Management and Opioid Use
- Pain Mechanisms and Treatments
- Opioid Use Disorder Treatment
- Spine and Intervertebral Disc Pathology
- Drug Transport and Resistance Mechanisms
- Pain Management and Placebo Effect
- Drug-Induced Hepatotoxicity and Protection
- Antifungal resistance and susceptibility
- Pharmaceutical Economics and Policy
- Blood Pressure and Hypertension Studies
- Patient Safety and Medication Errors
- Pharmacological Effects and Toxicity Studies
- Medication Adherence and Compliance
- Renal Transplantation Outcomes and Treatments
- Antibiotic Use and Resistance
- Schizophrenia research and treatment
- Inflammatory mediators and NSAID effects
- Complementary and Alternative Medicine Studies
- Anesthesia and Pain Management
The University of Sydney
2016-2025
Concord Repatriation General Hospital
2014-2023
Counties Manukau District Health Board
2012-2023
Pharmac
2020
Association for Jewish Studies
2020
St Vincent's Hospital Sydney
1994-2019
Concord Hospital
2009-2018
National Health and Medical Research Council
2011-2018
Nepean Hospital
2018
Westmead Hospital
2018
Atrial fibrillation (AF) causes a third of all strokes, but often goes undetected before stroke. Identification unknown AF in the community and subsequent anti-thrombotic treatment could reduce stroke burden. We investigated screening for using an iPhone electrocardiogram (iECG) pharmacies, determined cost-effectiveness this strategy.Pharmacists performedpulse palpation iECG recordings, with cardiologist over-reading. General practitioner review/12-lead ECG was facilitated suspected new AF....
Evidence about the association between treatment with high–risk medicines and frailty in older individuals is limited. We investigated relationship prescribing at baseline, as well 2–year incident frailty, 1,662 men ≥70 years of age. High–risk was defined polypharmacy (≥5 medicines), hyperpolypharmacy (≥10 by Drug Burden Index (DBI), a dose–normalized measure anticholinergic sedative medicines. At frail participants had adjusted odds ratios (ORs) 2.55 (95% confidence interval, CI: 1.69–3.84)...
Voriconazole is a first-line agent in the treatment of many invasive fungal infections and known to display highly variable pharmacokinetics. Previous studies voriconazole therapeutic drug monitoring (TDM) have suggested concentration be clinically useful but been limited by small patient samples at single institution. This multicenter retrospective study aimed investigate relationships between clinical outcomes adverse events assess factors interactions that may affect concentration....
Jansen and colleagues explore the role of shared decision making in tackling inappropriate polypharmacy older adults
Sciatica can be disabling, and evidence regarding medical treatments is limited. Pregabalin effective in the treatment of some types neuropathic pain. This study examined whether pregabalin may reduce intensity sciatica.We conducted a randomized, double-blind, placebo-controlled trial patients with sciatica. Patients were randomly assigned to receive either at dose 150 mg per day that was adjusted maximum 600 or matching placebo for up 8 weeks. The primary outcome leg-pain score on 10-point...
Aim The aim of this study was to investigate the effect St John's wort and ginseng on pharmacokinetics pharmacodynamics warfarin. Methods This an open‐label, three‐way crossover randomized in 12 healthy male subjects, who received a single 25‐mg dose warfarin alone or after 14 days’ pretreatment with wort, 7 ginseng. Dosing continued for days administration dose. Platelet aggregation, international normalized ratio (INR) prothrombin time, enantiomer protein binding, concentrations plasma...
Scope and purpose of the guidelinesThe clinical presentation a hot swollen joint is common has wide differential diagnosis.The most serious septic arthritis, with case fatality 11%.Delayed or inadequate treatment leads to damage.These guidelines focus on diagnosis management arthritis.Hot joints commonly have other underlying diagnoses, including crystal reactive arthritis monoarticular polyarthritis.
The aim of this study was to investigate the effect two common herbal medicines, ginkgo and ginger, on pharmacokinetics pharmacodynamics warfarin independent these herbs clotting status.