A5063915073- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Cerebral Palsy and Movement Disorders
- Neurological disorders and treatments
- Balance, Gait, and Falls Prevention
- Eicosanoids and Hypertension Pharmacology
- Neurological Disease Mechanisms and Treatments
- Colorectal Cancer Treatments and Studies
- MRI in cancer diagnosis
- Glaucoma and retinal disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Mental Health Research Topics
- Genomic variations and chromosomal abnormalities
- Cancer Immunotherapy and Biomarkers
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebrovascular and genetic disorders
- Cardiovascular Health and Disease Prevention
- Neuroinflammation and Neurodegeneration Mechanisms
- Cerebrospinal fluid and hydrocephalus
University of Toronto
1987-2025
University of the Philippines Diliman
2025
Baycrest Hospital
2020-2024
Sivas State Hospital
2024
Pathwest Laboratory Medicine
2024
Queen Elizabeth II Medical Centre
2024
Sunnybrook Health Science Centre
2020-2023
Health Sciences Centre
2020-2023
University of Central Florida
2023
Lake Erie College of Osteopathic Medicine
2023
Abstract Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location severity disease processes via saccade parameters measured from eye movement such as prosaccade antisaccade. Existing studies typically examine few in single diseases, using multiple separate neuropsychological test scores to relate behaviour cognition; however, this approach produces inconsistent,...
Neuropsychiatric symptoms (NPS) are a core feature of most neurodegenerative and cerebrovascular diseases. White matter hyperintensities brain atrophy have been implicated in NPS. We aimed to investigate the relative contribution white cortical thickness NPS participants across
Abstract INTRODUCTION Apolipoprotein E E4 allele ( APOE E4) and slow gait are independently associated with cognitive impairment dementia. However, it is unknown whether their coexistence poorer performance its underlying mechanism in neurodegenerative diseases. METHODS Gait speed, E4, cognition, neuroimaging were assessed 480 older adults neurodegeneration. Participants grouped by presence gait. Mediation analyses conducted to determine if brain structures could explain the link between...
Abstract Introduction Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods This multi‐site, longitudinal, observational cohort study recruited participants across prevalent diseases disease assessed comprehensively modalities. We describe univariate multivariate baseline features of the summarize recruitment, data collection, curation processes. Results enrolled 520 five diseases....
Although previously thought to be asymptomatic, recent studies have suggested that magnetic resonance imaging-visible perivascular spaces (PVS) in the basal ganglia (BG-PVS) of patients with Parkinson's disease (PD) may markers motor disability and cognitive decline. In addition, a pathogenic risk profile difference between small (≤3-mm diameter) large (>3-mm PVS has been suggested.The aim this study was examine associations quantitative measures BG-PVS, global cognition, motor/nonmotor...
Abstract Background and purpose The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, in the presence white matter hyperintensities (WMHs) cognitive motor impairments seem to be aggravated. However, role WMHs predicting accelerating symptom worsening remains controversial. objective was investigate whether location segmental WMH burden at baseline predict declines PD after 2 years. Methods Ninety‐eight older adults followed longitudinally from Ontario...
Objective Neuropsychiatric symptoms (NPS) are prevalent in neurodegenerative disorders, however, their frequency and impact on function across different disorders is not well understood. We compared the severity of NPS Alzheimer's disease (AD) (either with mild cognitive impairment or dementia), Cerebrovascular (CVD), Parkinson's (PD), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), explored association between burden function. Methods obtained data from Ontario...
Abstract Assessment of spoken language is a promising marker for cognitive impairment in individuals with cerebrovascular disease. However, the underlying neurological basis beyond single words and sentences remains poorly defined this cohort, particularly respect to white matter. This study aimed examine compare matter hyperintensity volumes diffusion tensor metrics normal-appearing (NAWM) as potential correlates performance. Baseline imaging data were obtained from disease cohort Ontario...
<sec> <title>BACKGROUND</title> Remote, interdisciplinary, observational clinical studies and trials are increasingly emerging in the scientific literature. Remote videoconference-based neuropsychological assessment offers numerous advantages, including improved access to care, reduced travel burden, ability monitor patients over time. However, such methodologies present challenges, particularly regarding fidelity of collected data. Data fidelity, defined as accuracy, completeness,...
<title>Abstract</title> Research on technology-based interventions for mental health continues to establish its significance within the landscape of services. Evidence has shown positive modest effects using applications various outcomes. This study explores effectiveness Social Activity Guardian and Intervention Project (SAGIP) mobile application designed University Philippines academic community. Using an experimental repeated measures design, SAGIP app was evaluated over a 6-month period....
Genetic factors contribute to neurodegenerative diseases, with high heritability estimates across diagnoses; however, a large portion of the genetic influence remains poorly understood. Many previous studies have attempted fill gaps by performing linkage analyses and association in individual disease cohorts, but failed consider clinical pathological overlap observed diseases potential for between phenotypes. Here, we leveraged rare variant (RVAAs) elucidate among multiple diagnoses,...
Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic [EpOME] 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods Results Participants mild moderate stroke or large were selected based on clinical imaging criteria. Metabolites quantified by ultra-high-performance liquid...
Acute change in gait speed while performing a mental task [dual-task cost (DTC)], and hyperintensity magnetic resonance imaging signals white matter are both important disability predictors older individuals with history of stroke (poststroke). It is still unclear, however, whether DTC associated overall volume from specific major brain regions poststroke.This cohort study total 123 (69 ± 7 years age) participants were included the Ontario Neurodegenerative Disease Research Initiative....
Alterations in tissue microstructure normal-appearing white matter (NAWM), specifically measured by diffusion tensor imaging (DTI) fractional anisotropy (FA), have been associated with cognitive outcomes following stroke. The purpose of this study was to comprehensively compare conventional DTI measures NAWM diverse vascular brain lesions people cerebrovascular disease (CVD) and examine associations between FA risk factors. metrics including mean diffusivity (MD), axial (AD), radial (RD)...
Abstract INTRODUCTION Cerebral small vessel disease (SVD) is common in patients with cognitive impairment and neurodegenerative diseases such as Alzheimer's Parkinson's. This study investigated the burden of magnetic resonance imaging (MRI)‐based markers SVD a function rare genetic variant carrier status. METHODS The Ontario Neurodegenerative Disease Research Initiative included 520 participants, recruited from 14 tertiary care centers, diagnosed various determined status non‐synonymous...
Abstract Objective In individuals over the age of 65, concomitant neurodegenerative pathologies contribute to cognitive and/or motor decline and can be aggravated by cerebrovascular disease, but our understanding how these synergize produce represents an important knowledge gap. The Ontario Neurodegenerative Disease Research Initiative (ONDRI), a multi-site, longitudinal, observational cohort study, recruited participants across multiple prevalent diseases collecting wide array data thus...
Caregiving burdens are a substantial concern in the clinical care of persons with neurodegenerative disorders. In Ontario Neurodegenerative Disease Research Initiative, we used Zarit's Burden Interview (ZBI) to examine: (1) types captured by ZBI cross-disorder sample conditions (2) whether there categorical or disorder-specific effects on caregiving burdens, and (3) which demographic, clinical, cognitive measures related burden(s) disorders?