Jane M. Lawrence‐Dewar
A5059886692- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Visual perception and processing mechanisms
- Motor Control and Adaptation
- Functional Brain Connectivity Studies
- Pain Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Parkinson's Disease Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Alzheimer's disease research and treatments
- Muscle activation and electromyography studies
- Neurological Disease Mechanisms and Treatments
- Tactile and Sensory Interactions
- Spinal Cord Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- EEG and Brain-Computer Interfaces
- Vestibular and auditory disorders
- Medical Image Segmentation Techniques
- Neural and Behavioral Psychology Studies
- Anesthesia and Sedative Agents
- Transcranial Magnetic Stimulation Studies
- Pain Management and Placebo Effect
Thunder Bay Regional Research Institute
2016-2025
Lakehead University
2024
NOSM University
2022
Thunder Bay Regional Health Sciences Centre
2019
University of Manitoba
2004-2013
Stanford University
2007-2011
University Hospital of Zurich
2007
Palo Alto University
2007
University of Tennessee Health Science Center
1995
Armed Forces Institute of Pathology
1979
White matter hyperintensities (WMHs) are frequently observed on structural neuroimaging of elderly populations and associated with cognitive decline increased risk dementia. Many existing WMH segmentation algorithms produce suboptimal results in vascular lesions or brain atrophy, require parameter tuning computationally expensive. Additionally, most do not generate a confidence estimate quality, limiting their interpretation. MRI-based methods often sensitive to acquisition protocols,...
Abstract Oculomotor tasks generate a potential wealth of behavioural biomarkers for neurodegenerative diseases. Overlap between oculomotor and disease-impaired circuitry reveals the location severity disease processes via saccade parameters measured from eye movement such as prosaccade antisaccade. Existing studies typically examine few in single diseases, using multiple separate neuropsychological test scores to relate behaviour cognition; however, this approach produces inconsistent,...
The Ontario Neurodegenerative Research Initiative (ONDRI) is a 3 years multi-site prospective cohort study that has acquired comprehensive multiple assessment platform data, including 3T structural MRI, from neurodegenerative patients with Alzheimer's disease, mild cognitive impairment, Parkinson's amyotrophic lateral sclerosis, frontotemporal dementia, and cerebrovascular disease. This heterogeneous cross-section of complex neurovascular pathologies pose significant challenges for standard...
Abstract Introduction Understanding synergies between neurodegenerative and cerebrovascular pathologies that modify dementia presentation represents an important knowledge gap. Methods This multi‐site, longitudinal, observational cohort study recruited participants across prevalent diseases disease assessed comprehensively modalities. We describe univariate multivariate baseline features of the summarize recruitment, data collection, curation processes. Results enrolled 520 five diseases....
Spontaneous variations in spinal cord activity may arise from regulation of any a number functions including sensory, motor, and autonomic control. Here, we use functional MRI (fMRI) healthy participants to identify properties blood oxygenation-level dependent (BOLD) the response knowledge that either noxious stimulus is impending, or no be expected. Expectation stimulus, shown have significant effect on wide-spread BOLD signal over entire time period fMRI acquisition. Coordination responses...
Abstract Purpose To develop a spinal functional MRI (fMRI) method with three‐dimensional coverage of large extent the cord minimal partial volume effects Materials and Methods fMRI data cervical were obtained at 1.5 T single‐shot fast spin‐echo imaging method, from thin contiguous sagittal slices spanning cord. Thermal stimulation was applied to palm hand in block pattern 15°C for 32°C during baseline periods. Prior analysis, image each time point reformatted into volumes resliced perfectly...
Background Cognitive strategies are a set of psychologic behaviors used to modulate one's perception or interpretation sensation situation. Although the effectiveness each cognitive strategy seems differ between individuals, they commonly clinically help patients with chronic pain cope their condition. The neural basis is not well understood. Understanding correlates that underlie these will enhance understanding analgesic network brain and modulation pain. Methods current study examines...
Abstract Purpose: To use spinal cord diffusion tensor imaging (DTI) for investigating human cervical funiculi, acquire axial magnetic resonance (MRI) data with an in‐plane resolution sufficient to delineate subquadrants within the cord, obtain corresponding DTI metrics, and assess potential regional differences. Materials Methods: Healthy volunteers were studied a 3 T Siemens Trio MRI scanner. acquired using single‐shot spin echo EPI sequence. The spatial allowed delineation of regions...
Background Regional changes to cortical thickness in individuals with neurodegenerative and cerebrovascular diseases (CVD) can be estimated using specialized neuroimaging software. However, the presence of cerebral small vessel disease, focal atrophy, cortico-subcortical stroke lesions, pose significant challenges that increase likelihood misclassification errors segmentation failures. Purpose The main goal this study was examine a correction procedure developed for enhancing FreeSurfer’s...
Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic [EpOME] 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods Results Participants mild moderate stroke or large were selected based on clinical imaging criteria. Metabolites quantified by ultra-high-performance liquid...
Abstract Objective In individuals over the age of 65, concomitant neurodegenerative pathologies contribute to cognitive and/or motor decline and can be aggravated by cerebrovascular disease, but our understanding how these synergize produce represents an important knowledge gap. The Ontario Neurodegenerative Disease Research Initiative (ONDRI), a multi-site, longitudinal, observational cohort study, recruited participants across multiple prevalent diseases collecting wide array data thus...
The diagnosis of acute Guillain‐Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy is based on clinical characteristics, abnormalities nerve conduction studies, biopsy specimens indicating demyelination. Inflammation edema are also common findings in Immunotherapy helpful these dysimmune conditions. Occasionally the difficult to make, particularly when electrophysiological testing or not characteristic. authors found contrast enhancement lumbosacral roots patients...
When viewing a face, healthy individuals focus more on the area containing eyes and upper nose in order to retrieve important featural configural information. In contrast, with face blindness (prosopagnosia) tend direct fixations toward individual facial features-particularly mouth. Presented here is an examination of perception deficits Posterior Cortical Atrophy (PCA). PCA rare progressive neurodegenerative disorder that characterized by atrophy occipito-parietal occipito-temporal...