A5055781836- Advanced Neuroimaging Techniques and Applications
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Glioma Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Motor Control and Adaptation
- Muscle activation and electromyography studies
- Pelvic floor disorders treatments
- Vascular Malformations Diagnosis and Treatment
- Spinal Cord Injury Research
- Urinary Tract Infections Management
- Spinal Dysraphism and Malformations
- Cerebrospinal fluid and hydrocephalus
- Neurological disorders and treatments
- Fetal and Pediatric Neurological Disorders
- Transcranial Magnetic Stimulation Studies
- Medical Imaging Techniques and Applications
- Brain Metastases and Treatment
- Stroke Rehabilitation and Recovery
- Neural dynamics and brain function
- Psychosomatic Disorders and Their Treatments
- Cerebrovascular and Carotid Artery Diseases
- Pituitary Gland Disorders and Treatments
- Cerebral Palsy and Movement Disorders
University Hospital of Zurich
2014-2023
University of Zurich
2012-2021
Stanford University
2020
Evangelismos Hospital
2004-2015
ETH Zurich
2003-2015
Kantonsspital Aarau
2003-2015
Institute of Neurobiology
2000-2011
Zurich University of the Arts
2011
Institute for Biomedical Engineering
2010
University of St. Gallen
2006
Rechallenge with temozolomide (TMZ) at first progression of glioblastoma after chemoradiotherapy (TMZ/RT→TMZ) has been studied in retrospective and single-arm prospective studies, applying continuously or using 7/14 21/28 days schedules. The DIRECTOR trial sought to show superiority the regimen.Patients TMZ/RT→TMZ least two maintenance cycles were randomized Arm A [one week on (120 mg/m(2) per day)/one off] B [3 weeks (80 off]. primary endpoint was median time-to-treatment failure (TTF)...
Object. The purpose of the present study was to compare results functional magnetic resonance (fMR) imaging with those intraoperative cortical stimulation in patients who harbored tumors close or involving primary motor area and assess usefulness fMR objective evaluation function as part surgical strategy treatment these patients. Methods. A total 11 consecutive patients, whose were central region, underwent presurgical blood oxygen level—dependent while performing a paradigm that required...
Fuzzy logic clustering algorithms are a new class of processing strategies for functional MRI (fMRI). In this study, the ability such methods to detect brain activation on application stimulus task is demonstrated. An optimization selected algorithm with regard different parameters proposed. These include (a) those defining pre-processing procedure data set; (b) definition distance between two time courses, considered as p-dimensional vectors, where p number sequential images in fMRI and (c)...
Phantom limbs are traditionally conceptualized as the phenomenal persistence of a body part after deafferentation. Previous clinical observations subjects with phantoms congenitally absent not compatible this view, but, in absence experimental work, neural basis such “aplasic phantoms” has remained enigmatic. In paper, we report series behavioral, imaging, and neurophysiological experiments university-educated woman born without forearms legs, who experiences vivid phantom sensations all...
Brain activation during motor imagery has been the subject of a large number studies in healthy subjects, leading to divergent interpretations with respect role descending pathways and kinesthetic feedback on mental rehearsal movements. We investigated patients complete spinal cord injury (SCI) find out how disruption efferents sensory afferents influences brain disconnected feet. Eight SCI underwent behavioral assessment functional magnetic resonance imaging. When compared population,...
The task-positive network (TPN) is anticorrelated with activity in the default mode (DMN), and possibly reflects competition between processing of external internal information, while salience (SN) pivotal regulating TPN DMN activity. Because abnormal functional connectivity these networks has been related to schizophrenia, we tested whether alterations are also evident subjects at risk for psychosis. Resting-state magnetic resonance imaging was 28 basic symptoms reporting subjective...
Considering PET/MR imaging as a whole-body staging tool, scan time restrictions in single body area are mandatory for the cost-effective clinical operation of an integrated multimodality scanner setting. It has to be considered that <sup>18</sup>F-FDG already acts contrast agent and under certain circumstances MR may not yield additional clinically relevant information. The concept present study was understand which portions information enhance sensitivity specificity hybrid examination...
The combination of first-person observation and motor imagery, i.e. limbs with online imagination, is commonly used in interactive 3D computer gaming some movie scenes. These scenarios are designed to induce a cognitive process which subject imagines himself/herself acting as the agent displayed movement situation. Despite ubiquity this type interaction its therapeutic potential, relationship passive imitation during has not been directly studied using an paradigm. In present study we show...
Conditions with chronically elevated glucocorticoid levels are usually associated declarative memory deficits. Considerable evidence suggests that long-term exposure may cause cognitive impairment via cumulative and long-lasting influences on hippocampal function morphology. However, because at the time of retention testing also known to have direct impairing effects retrieval, it is possible such acute hormonal retrieval processes contribute deficits found chronic exposure. To investigate...
Motor imagery (MI) has shown effectiveness in enhancing motor performance. This may be due to the common neural mechanisms underlying MI and execution (ME). The main region of ME network, primary cortex (M1), been consistently linked However, activation M1 during is controversial, which account for inconsistent rehabilitation therapy outcomes using MI. Here, we examined relationship between contralateral (cM1) changes sensorimotor To aid cM1 activity modulation MI, used real-time fMRI...
Emerging evidence has attributed altered network coordination between the default mode, central executive, and salience networks (DMN/CEN/SAL) to disturbances seen in schizophrenia, but little is known for at-risk psychosis stages. Moreover, pinpointing impairments specific network-to-network interactions, although essential resolve possibly distinct harbingers of conversion clinically diagnosed remains particularly challenging. We addressed this by a dynamic approach functional...
Rehabilitative training has shown to improve significantly motor outcomes and functional walking capacity in patients with incomplete spinal cord injury (iSCI). However, whether performance improvements during rehabilitation relate brain plasticity or it is based on adaptation of movement strategies remain uncertain. This study assessed improvement-induced structural chronic iSCI using longitudinal MRI. We used tensor-based morphometry (TBM) analyze volume changes associated intensive...