A5006411265- Epilepsy research and treatment
- Neuroscience and Neuropharmacology Research
- Pharmacological Effects and Toxicity Studies
- EEG and Brain-Computer Interfaces
- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Memory and Neural Mechanisms
- Metabolism and Genetic Disorders
- Neural dynamics and brain function
- Diet and metabolism studies
- Neuroscience and Music Perception
- Neurobiology of Language and Bilingualism
- Cerebrospinal fluid and hydrocephalus
- Electromagnetic Fields and Biological Effects
- Vascular Malformations Diagnosis and Treatment
- Neonatal and fetal brain pathology
- Drug Transport and Resistance Mechanisms
- Meningioma and schwannoma management
- Trace Elements in Health
- Magnetic and Electromagnetic Effects
- Advanced Neuroimaging Techniques and Applications
- Prion Diseases and Protein Misfolding
- Fetal and Pediatric Neurological Disorders
University of Zurich
1997-2017
University Hospital of Zurich
2005-2016
Klinik und Poliklinik für Neurologie
1998-2009
Swiss Epilepsy Center
2006
Foederatio Medicorum Helveticorum
2006
Toronto Western Hospital
2005
University of Toronto
2005
Universitäts Frauenklinik
1998-2003
Institute for Biomedical Engineering
2001
ETH Zurich
2001
Experts discussed the definition, natural history, pathologic features, pathogenesis, electroclinical, neurophysiological, neuropsychological, structural and functional imaging findings, as well surgical outcome in mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS). After a long-lasting consensus process ILAE Commission Neurosurgery of accepted resulting conclusions state-of-the art report on MTLE-HS. The majority contributors considered MTLE-HS to represent sufficient...
Studies of amnesia have demonstrated that the hippocampus is necessary for long-term memory, but its precise role in memory unknown. We designed a positron emission tomography experiment with tailored encoding and retrieval tasks permitted isolation different mnemonic functions theorized to be mediated by hippocampus. These included single items, establishing interitem associations, novelty detection, retrieving recently formed associations. Of these, we found hippocampal parahippocampal...
Temporal lobe epilepsy (TLE) is associated with impaired inhibitory neurotransmission. Studies in animal models suggest that GABA(A) receptor dysfunction contributes to epileptogenesis. To understand the mechanisms underlying TLE humans, it fundamental determine whether and how subtypes are altered. Furthermore, identifying novel targets a prerequisite for developing selective antiepileptic drugs. We have therefore analyzed subunit composition distribution of three major...
The hippocampal formation, one of the most complex and vulnerable brain structures, is recognized as a crucial area subserving human long-term memory. Yet, its specific functions in memory are controversial. Recent experimental results suggest that contribution to limited episodic memory, novelty detection, semantic (deep) processing information, spatial We measured regional cerebral blood flow by positron-emission tomography while healthy volunteers learned pairs words with different...
Object. The purpose of the present study was to compare results functional magnetic resonance (fMR) imaging with those intraoperative cortical stimulation in patients who harbored tumors close or involving primary motor area and assess usefulness fMR objective evaluation function as part surgical strategy treatment these patients. Methods. A total 11 consecutive patients, whose were central region, underwent presurgical blood oxygen level—dependent while performing a paradigm that required...
Deletions at 16p13.11 are associated with schizophrenia, mental retardation, and most recently idiopathic generalized epilepsy. To evaluate the role of deletions, as well other structural variation, in epilepsy disorders, we used genome-wide screens to identify copy number variation 3812 patients a diverse spectrum syndromes 1299 neurologically-normal controls. Large deletions (> 100 kb) were observed 23 patients, whereas no control had deletion greater than 16 kb. Patients, even those...
Analyses of the results surgery for epilepsy are hindered by inconsistent classifications seizure outcome, small numbers patients, and short postoperative follow-up periods. The authors conducted a retrospective study with reassessment long-term outcomes in patients who underwent selective amygdalohippocampectomy (SelAH) pharmacotherapy-resistant mesial temporal lobe (MTLE) at Zurich University Hospital from 1975 to 1999.Year-by-year data last available on were retrospectively assessed 369...
Partial epilepsies have a substantial heritability. However, the actual genetic causes are largely unknown. In contrast to many other common diseases for which association-studies successfully revealed variants associated with disease risk, role of variation in partial has not yet been explored well-powered study. We undertook genome-wide association-study identify influence risk epilepsy shared amongst syndromes, 3445 patients and 6935 controls European ancestry. did any significant...
Metabolic abnormalities in the temporal lobe (TL) of 25 patients suffering from epilepsy mesiobasal or lateral TL origin have been investigated using interictal [<sup>18</sup>F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). The epileptogenic area was determined by ictal EEG recordings foramen ovale and scalp electrodes 20 patients, use stereo-electroencephalography one patient. Four with structural lesions on their MRIs had noninvasive surface recordings. Sixteen a clear-cut...
Our purpose was to review the current role of invasive and semi-invasive EEG in presurgical evaluation candidates for epilepsy surgery. The use stereotactically implanted intracranial depth (stereo-EEG), subdural strip grid, foramen ovale electrodes, as well intraoperative electrocorticography electrical brain stimulation ("functional mapping") at Epilepsy Center University Hospital Zurich, from 1984 1998, is analyzed. Advantages disadvantages various techniques are critically discussed. Out...
The Executive Committee of the ILAE has approved following report Commission on Neurosurgery for publication as a PROPOSAL. seeks input regarding document and welcomes any suggestions changes, including additions, modifications, deletions. proposal, therefore, is very much draft document, which will likely require further alteration before being accepted new outcome classification use with epilepsy surgery. Feedback may be in form either Letters to Editor or directly Professor H. Gregor...
The authors evaluated the feasibility and source localization utility of H<sub>2</sub><sup>15</sup>O or <sup>13</sup>NH<sub>3</sub> PET low-resolution electromagnetic tomography (LORETA) in three patients with partial status epilepticus (SE). Results were correlated findings from intraoperative electrocorticographic recordings surgical outcomes. studies cerebral blood flow noninvasive modeling LORETA using statistical nonparametric mapping provided useful information for localizing ictal activity SE.
Summary: Greater precision in the identification of seizure‐initiating structures and preferential pathways seizure spread has enabled us to classify complex partial seizures into subtypes. The mediobasal limbic subtype is most important these. Because paramount importance amygdala hippocampus majority patients with temporal lobe epilepsy, we initiated so‐called “selective” amygdalo‐hippocampectomy (AHE) as an alternative conventional lobectomy for treatment medically intractable epilepsy....
Summary: We report data from four patients with unilateral epileptiform status activity within different structures of the temporal lobe, recorded during stereoelectroencephalographic presurgical evaluation. The ictal clinical symptoms accompanying neocortical and mesiobasal limbic discharges (two complex partial epilepticus) consisted various psychosensory vegetative signs, which can be understood on basis spatiotemporal analysis discharges. other two circumscribed long‐lasting represent...
Glutathione in its reduced form (GSH) is the most important free radical scavenging compound mammalian nervous system that prevents membrane lipid peroxidation. It suspected epileptic seizures are accompanied by a massive production of reactive oxygen species, i.e., oxidative stress.Using an (1)H MRS technique developed at authors' site, authors measured glutathione levels volume interest (VOI) 25 x mm placed structurally normal-appearing tissue parietooccipital region each hemispheres...