A5036696155- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Pharmacological Effects and Toxicity Studies
- Functional Brain Connectivity Studies
- Neuroscience and Neural Engineering
- Neural dynamics and brain function
- Neurobiology of Language and Bilingualism
- Neonatal and fetal brain pathology
- Advanced MRI Techniques and Applications
- Memory and Neural Mechanisms
- Metabolism and Genetic Disorders
- Motor Control and Adaptation
- Diet and metabolism studies
- Transcranial Magnetic Stimulation Studies
- Mitochondrial Function and Pathology
- Cerebrospinal fluid and hydrocephalus
- Intraoperative Neuromonitoring and Anesthetic Effects
- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Fetal and Pediatric Neurological Disorders
- Glycogen Storage Diseases and Myoclonus
- Neurology and Historical Studies
- Hemispheric Asymmetry in Neuroscience
University Hospitals of Cleveland
2009-2024
Case Western Reserve University
2014-2024
University School
1985-2024
The Neurological Institute
2009-2024
The University of Melbourne
2024
Cleveland Clinic
2000-2020
The University of Texas Health Science Center at Houston
2020
University Hospitals Cleveland Medical Center
2008-2019
Rainbow Babies & Children's Hospital
2015
Niigata University
2007
INTRODUCTION PRINCIPLES FOR TERMS AND DEFINITIONS DATA SOURCES I GENERAL 1.0 SEMIOLOGY 2.0 EPILEPTIC SEIZURE 3.0 ICTUS 4.0 EPILEPSY 5.0 FOCAL 6.0 GENERALIZED 7.0 CONVULSION II DESCRIBING MOTOR 1.1 ELEMENTARY 1.1.1 TONIC 1.1.1.1 SPASM 1.1.1.2 POSTURAL 1.1.1.2.1 VERSIVE 1.1.1.2.2 DYSTONIC 1.1.2 MYOCLONIC 1.1.2.1 NEGATIVE 1.1.2.2 CLONIC 1.1.2.2.1 JACKSONIAN MARCH 1.1.3 TONIC-CLONIC 1.1.3.1 1.1.4 ATONIC 1.1.5 ASTATIC 1.1.6 SYNCHRONOUS 1.2 AUTOMATISM 1.2.1 OROALIMENTARY 1.2.2 MIMETIC 1.2.3 MANUAL...
A better understanding of the mechanisms involved in human higher cortical functions requires a detailed knowledge neuronal connectivity between functional regions. Currently no good method for tracking vivo exists. We investigated inter-areal connections language system using new method, which we termed 'cortico-cortical evoked potentials' (CCEPs). Eight patients with epilepsy (age 13-42 years) underwent invasive monitoring subdural electrodes surgery. Six had dominance on side grid...
We propose an epileptic seizure classification based exclusively on ictal semiology. In this semiological (SSC), seizures are classified as follows: a. Auras manifestations having sensory, psychosensory, and experiential symptoms. b. Autonomic in which the main objectively documented autonomic alterations. c. "Dialeptic" have their alteration of consciousness that is independent EEG manifestations. The new term "dialeptic" has been coined to differentiate concept from absence (dialeptic with...
We describe 6 patients who demonstrated postoperative neurological deficits despite unchanged somatosensory evoked potentials during intraoperative monitoring. Although there is both experimental and clinical evidence that are sensitive to some types of mishap, the technique should be employed with an awareness its possible limitations.
Movement-related potentials (MRPs) were recorded from subdural electrodes chronically implanted in the interhemispheric fissure two patients being evaluated for epilepsy surgery. Different types of movements (finger, foot, tongue and vocalization) executed. Foot elicited a clearly defined, well-localized slow negativity or positivity (Bereitschaftspotential, BP) preceding electromyogram (EMG) onset. These BPs seen contralateral primary motor foot area also bilateral supplementary areas...
Summary: Forty‐seven patients with structural brain lesions on neuroimaging studies and partial epilepsy intractable to medical therapy were studied. Prolonged noninvasive interictal ictal EEG recording was performed, followed by more focused mapping using chronically implanted subdural electrode plates. Surgical procedures included lesion biopsy, maximal excision, and/or resection of zones epileptogenesis depending accessibility involvement speech or other functional areas. The...
In order to understand the complex functional organization of motor system, it is essential know anatomical and connectivity among individual areas. Clinically, knowledge these cortico-cortical connections important rapid spread epileptic discharges through network underlying ictal manifestation. humans, however, neuronal in vivo has been limited. We recently reported a new method, 'cortico-cortical evoked potential (CCEP)', electrically track by stimulating part brain subdural electrodes...
Language interference was elicited by electrical stimulation of the dominant basal temporal region in 8 out 22 cases and none 7 with subdural electrodes implanted over nondominant lobe. placed fusiform gyrus 3–7 cm from tip
To evaluate the risk factors, type, and frequency of complications during video-EEG monitoring with subdural grid electrodes.The authors retrospectively reviewed records all patients who underwent invasive electrodes (n = 198 sessions on 187 patients; median age: 24 years; range: 1 to 50 years) at Cleveland Clinic Foundation from 1980 1997.From 1997, complication rate decreased (p 0.003). In last 5 years, 19/99 (19%) had complications, including two (2%) permanent sequelae. 3 was 13.5% 5/37)...
Abstract The interpretation of change scores in neuropsychological assessment is increasing importance. In order to illustrate a regression approach depicting change, 50 patients with chronic seizure disorders were assessed twice the WAIS-R and Wechsler Memory Scale-Revised over an average interval 7.8 months. Regression analysis was employed develop norms for that converted into standardized scores. These T Scores Change analyzed MANOVA compare effects epilepsy surgery on cognition memory...
To investigate the lateralization and localization of ictal EEG in focal epilepsy.A total 486 72 patients with epilepsy arising from mesial temporal, neocortical frontal, dorsolateral parietal, occipital regions were analyzed.Surface was adequately localized 72% cases, more often temporal than extratemporal epilepsy. Localized onsets seen 57% seizures most common lobe (MTLE), lateral frontal (LFLE), parietal epilepsy, whereas lateralized predominated generalized (MFLE) Approximately...
Abstract Traditional methods for assessing the neurocognitive effects of epilepsy surgery are confounded by practice effects, test-retest reliability issues, and regression to mean. This study employs 2 individual change that allow direct comparison changes across both individuals test measures. Fifty-one medically intractable patients completed a comprehensive neuropsychological battery twice, approximately 8 months apart, prior any invasive monitoring or surgical intervention. First,...
The relationship between preoperative ability levels and postoperative changes in cognitive function was examined among 23 left (LTL) 19 right (RTL) temporal lobectomy patients using a battery of memory, language, visuospatial tasks administered approximately 3 months before surgery at 6 follow-up. Higher performances on the memory language measures were associated with larger decrements postsurgical scores LTL patients. RTL group showed no consistent subsequent changes. Based present data,...