A5065264098- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Neonatal and fetal brain pathology
- Neurological disorders and treatments
- Atomic and Subatomic Physics Research
- Motor Control and Adaptation
- Neuroscience and Neural Engineering
- Muscle activation and electromyography studies
- Pharmacological Effects and Toxicity Studies
- Heart Rate Variability and Autonomic Control
- Financial Markets and Investment Strategies
- Pain Mechanisms and Treatments
- Obstructive Sleep Apnea Research
- Blind Source Separation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Corporate Finance and Governance
- Healthcare Technology and Patient Monitoring
- Cardiovascular Syncope and Autonomic Disorders
- Acute Ischemic Stroke Management
- Neural and Behavioral Psychology Studies
- Risk and Portfolio Optimization
Cleveland Clinic
2015-2024
Case Western Reserve University
1978-2024
Chesapeake Bay Program
2011-2024
Heidenhain (United Kingdom)
2023
University of Bristol
2023
The Neurological Institute
2012-2022
Epilepsy Foundation
2016-2019
Elekta (Switzerland)
2017
The University of Texas Health Science Center at Houston
2015
Epilepsy Foundation
2015
We propose an epileptic seizure classification based exclusively on ictal semiology. In this semiological (SSC), seizures are classified as follows: a. Auras manifestations having sensory, psychosensory, and experiential symptoms. b. Autonomic in which the main objectively documented autonomic alterations. c. "Dialeptic" have their alteration of consciousness that is independent EEG manifestations. The new term "dialeptic" has been coined to differentiate concept from absence (dialeptic with...
Movement-related potentials (MRPs) were recorded from subdural electrodes chronically implanted in the interhemispheric fissure two patients being evaluated for epilepsy surgery. Different types of movements (finger, foot, tongue and vocalization) executed. Foot elicited a clearly defined, well-localized slow negativity or positivity (Bereitschaftspotential, BP) preceding electromyogram (EMG) onset. These BPs seen contralateral primary motor foot area also bilateral supplementary areas...
We studied proprioception with the ankle joint and metacarpophalangeal (MCP) of index finger humans by use a method that could distinguish position sense from movement sense. The test measured how subjects' ability to detect fixed displacement varied rate rotation. A should not depend on speed placement; therefore slow rates degrade displacements. However, in absence sense, subjects would presumably rely signals do rotation, their displacements decrease when decreases. Subjects small (+/-...
To evaluate the risk factors, type, and frequency of complications during video-EEG monitoring with subdural grid electrodes.The authors retrospectively reviewed records all patients who underwent invasive electrodes (n = 198 sessions on 187 patients; median age: 24 years; range: 1 to 50 years) at Cleveland Clinic Foundation from 1980 1997.From 1997, complication rate decreased (p 0.003). In last 5 years, 19/99 (19%) had complications, including two (2%) permanent sequelae. 3 was 13.5% 5/37)...
Ictal asystole (IA) is a rare event mostly seen in patients with temporal lobe epilepsy (TLE) and potential contributor to sudden unexplained death (SUDEP). Clinical video-electroencephalographic findings associated IA have not been described, may be helpful screening for high risk patients.A database search was performed of 6,825 undergoing long-term video-EEG monitoring episodes IA.IA recorded 0.27% all epilepsy, eight (TLE), two extratemporal (XTLE), none generalized epilepsy. In 8 out 16...
In the presurgical workup of magnetic resonance imaging (MRI)-negative (MRI(-) or "nonlesional") pharmacoresistant focal epilepsy (PFE) patients, discovering a previously undetected lesion can drastically change evaluation and likely improve surgical outcome. Our study utilizes voxel-based MRI postprocessing technique, implemented in morphometric analysis program (MAP), to facilitate detection subtle abnormalities consecutive cohort MRI(-) candidates.Included this retrospective was 150...
See Bear and Kirsch (doi:10.1093/aww248) for a scientific commentary on this article. Magnetoencephalography stereo-electroencephalography are often necessary in the course of non-invasive invasive presurgical evaluation challenging patients with medically intractable focal epilepsies. In study, we aim to examine significance magnetoencephalography dipole clusters their relationship findings, area surgical resection, seizure outcome. We also define positive negative predictors based cluster...
Summary: Purpose: Objectively to evaluate whether independent spike detection by human interpreters is clinically valid in magnetoencephalography (MEG) and characterize differences between MEG scalp electroencephalography (EEG). Methods: We simultaneously recorded EEG data from 43 patients with intractable focal epilepsy. Raw waveforms were reviewed independently two experienced epileptologists, one for MEG, blinded the other modality clinical information. The number localization of spikes...
Abstract The effect of subthalamic nucleus (STN) stimulation on cortical electroencephalographic activity was examined in 10 patients with Parkinson's disease and 4 epilepsy. Evoked potentials were created by time‐locking electroencephalography to the onset electrical delivered through lead implanted STN who had previously undergone deep brain (DBS) surgery. different patterns evoked response, including single‐ paired‐pulse as well burst stimulation, explored. Cortical single pulses observed...
This project aimed to determine if a correlation-based measure of functional connectivity can identify epileptogenic zones from intracranial EEG signals, as well investigate the prognostic significance such on seizure outcome following temporal lobe lobectomy. To this end, we retrospectively analyzed 23 adult patients with intractable epilepsy (TLE) who underwent an invasive stereo-EEG (SEEG) evaluation between January 2009 year and 2012. A follow-up at least one was required. The primary...
MRI-negative (MRI-) pharmacoresistant focal epilepsy (PFE) patients are most challenging for surgical management. This study utilizes a voxel-based MRI postprocessing technique, implemented using morphometric analysis program (MAP), aiming to facilitate detection of subtle cortical dysplasia (FCD) in MRI- patients. Furthermore, the examines concordance between MAP-identified regions and localization from magnetic source imaging (MSI).Included this retrospective were 25 MAP was performed on...
Abstract Objective This study aims to evaluate the role of scalp electroencephalography (EEG; ictal and interictal patterns) in predicting resective epilepsy surgery outcomes. We use data further develop a nomogram predict seizure freedom. Methods retrospectively reviewed EEG findings clinical patients who underwent surgical resection at three centers. Using both variables categorized into 13 isolated candidate predictors 6 interaction terms, we built multivariable Cox proportional hazards...
Proprioceptive ability with the proximal interphalangeal (PIP) and metacarpophalangeal (MCP) joints of index finger in human subjects was examined using a method that could assess staticposition sense independently movement (Clark et al., 1985). The similarity location function these would suggest similar proprioceptive mechanisms, but found to be quite different for two joints. distinguishing static-position from based on whether subject's detect small change joint position impaired when...
Article abstract-We recorded interictal spikes with closely spaced scalp electrodes and sphenoidal in four patients temporal lobe epilepsy. We used multiple dipole modeling to study the number, three-dimensional intracerebral location, time activity, functional relationship of neuronal sources underlying epileptic spike complexes. In all patients, we found two significant generating which showed considerable overlap both space time. Source 1 was located mesiobasal generated a restricted...