A5051585576- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- NMR spectroscopy and applications
- Metabolomics and Mass Spectrometry Studies
- Functional Brain Connectivity Studies
- Electron Spin Resonance Studies
- Advanced Neuroimaging Techniques and Applications
- Nuclear Physics and Applications
- Cardiac Imaging and Diagnostics
- Treatment of Major Depression
- Wireless Body Area Networks
- Neuroscience and Neuropharmacology Research
- Lanthanide and Transition Metal Complexes
- Diet and metabolism studies
- Optical Imaging and Spectroscopy Techniques
- Metabolism and Genetic Disorders
- MRI in cancer diagnosis
- Antenna Design and Analysis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Ultrasound Imaging and Elastography
- Ultrasound and Hyperthermia Applications
- Sparse and Compressive Sensing Techniques
- Energy Harvesting in Wireless Networks
The University of Texas Southwestern Medical Center
2019-2025
Advanced Imaging Research (United States)
2019-2025
Allegheny Health Network
2025
Max Planck Institute for Biological Cybernetics
2015-2024
ETH Zurich
2013-2024
Institute for Biomedical Engineering
2014-2024
University of Zurich
2012-2024
Swiss Integrative Center for Human Health
2011-2024
Southwestern Medical Center
2020-2024
Southwestern University
2022-2024
The polypyrimidine tract binding protein (PTB) is a 58-kilodalton RNA involved in multiple aspects of messenger metabolism, including the repression alternative exons. We have determined solution structures four domains (RBDs) PTB, each bound to CUCUCU oligonucleotide. Each RBD binds with different specificity. RBD3 and RBD4 interact, resulting an antiparallel orientation their RNAs. Thus, PTB will induce looping when two separated pyrimidine tracts within same RNA. This leads structural...
<h3>Context</h3> Major depressive disorder (MDD) is characterized by diverse metabolic and functional abnormalities that occur in, among other regions, the pregenual anterior cingulate cortex (pgACC), a cortical region linked to anhedonia. <h3>Objectives</h3> To contextualize metabolic, functional, clinical parameters thus reveal cellular mechanisms related <h3>Design</h3> The pgACC was investigated using combined magnetic resonance imaging spectroscopic approach. Negative blood oxygenation...
Background— Hypertrophic cardiomyopathy patients exhibit myocardial energetic impairment, but a causative role for this energy deficiency in the pathophysiology of hypertrophic remains unproven. We hypothesized that metabolic modulator perhexiline would ameliorate and thereby improve diastolic function exercise capacity. Methods Results— Forty-six consecutive with symptomatic limitation (peak V̇ o 2 <75% predicted) caused by nonobstructive (mean age, 55±0.26 years) were randomized to 100...
Increasing preclinical and clinical evidence underscores the strong rapid antidepressant properties of glutamate-modulating NMDA receptor antagonist ketamine. Targeting glutamatergic system might thus provide a novel molecular strategy for treatment. Since glutamate is most abundant major excitatory neurotransmitter in brain, pathophysiological changes signaling are likely to affect neurobehavioral plasticity, information processing large-scale functional brain connectivity underlying...
Acute stress-induced (takotsubo) cardiomyopathy can result in a heart failure phenotype with prognosis comparable that of myocardial infarction. In this study, we hypothesized inflammation is central to the pathophysiology and natural history takotsubo cardiomyopathy.In multicenter prospectively recruited 55 patients 51 age-, sex-, comorbidity-matched control subjects. During index event at 5-month follow-up, underwent multiparametric cardiac magnetic resonance imaging, including ultrasmall...
Takotsubo cardiomyopathy is an increasingly recognized acute heart failure syndrome precipitated by intense emotional stress. Although there apparent rapid and spontaneous recovery of left ventricular ejection fraction, the long-term clinical functional consequences takotsubo are ill-defined.In observational case-control study, we recruited 37 patients with prior (>12-month) cardiomyopathy, age-, sex-, comorbidity-matched control subjects. Patients completed Minnesota Living Heart Failure...
Abstract A spin‐echo single‐shot echo‐planar imaging (SS‐EPI) technique with a reduced field of view (FOV) in the phase‐encoding direction is presented that simultaneously reduces susceptibility effects and motion artifacts diffusion‐weighted (DW) (DWI) spinal cord at high strength (3T). To minimize aliasing, an outer volume suppression (OVS) sequence was implemented. Effective fat achieved use slice‐selection gradient‐reversal technique. The OVS optimized by numerical simulations respect to...
Abstract In comparison to 1.5 and 3 T, MR spectroscopic imaging at 7 T benefits from signal‐to‐noise ratio (SNR) gain increased spectral resolution should enable mapping of a large number metabolites high spatial resolutions. However, take full advantage the ultra‐high field strength, severe technical challenges, e.g. related very short 2 relaxation times strict limitations on maximum achievable B 1 have be resolved. The latter results in considerable decrease bandwidth for conventional...
Proton MR spectra of the brain, especially those measured at short and intermediate echo times, contain signals from mobile macromolecules (MM). A description main MM is provided in this consensus paper. These broad peaks underlie narrower metabolites often complicate their quantification but they also may have potential importance as biomarkers specific diseases. Thus, separation low molecular weight enables accurate determination metabolite concentrations primary interest many studies....
Magnetic resonance spectroscopic imaging (MRSI) offers considerable promise for monitoring metabolic alterations associated with disease or injury; however, to date, these methods have not had a significant impact on clinical care, and their use remains largely confined the research community limited number of sites. The MRSI currently implemented MRI instruments remained essentially unchanged two decades, only incremental improvements in sequence implementation. During this time,...
The development of novel radiofrequency (RF) coils for human ultrahigh‐field (≥7 T), non‐proton and body applications is an active field research in many MR groups. Any RF coil must meet the strict requirements safe application on humans with respect to mechanical electrical safety, as well specific absorption rate (SAR) limits. For this purpose, regulations such International Electrotechnical Commission (IEC) standard medical equipment, vendor‐suggested test specifications third party...
Magnetic resonance spectroscopy (MRS) and spectroscopic imaging (MRSI) allow the chemical analysis of physiological processes in vivo provide powerful tools life sciences for clinical diagnostics. Excellent homogeneity static B 0 magnetic field over object interest is essential achieving high‐quality spectral results quantitative metabolic measurements. The experimental minimization variation performed a process called shimming. In this article, we summarize concepts shimming using spherical...
To present first highly spatially resolved deuterium metabolic imaging (DMI) measurements of the human brain acquired with a dedicated coil design and fast chemical shift (CSI) sequence at an ultrahigh field strength B0 = 9.4 T. 2H temporal resolution 10 min enabled investigation glucose metabolism in healthy subjects.The study was performed double-tuned TxRx channels for 1H 8TxRx/2Rx Ernst angle 3D CSI nominal spatial 2.97 ml min.The [6,6'-2H2]-labeled due to TCA cycle could be made visible...
Purpose To explore the potential of deuterium metabolic imaging (DMI) in human brain vivo at 7 T, using a multi‐element ( 2 H) RF coil for 3D volume coverage. Methods 1 H‐MR images and localized H MR spectra were acquired 3 healthy subjects to generate DMI maps H‐labeled water, glucose, glutamate/glutamine (Glx). In addition, non‐localized both vitro determine T relaxation times deuterated metabolites T. The performance was assessed through numeric simulations experimentally B + maps....
Increased amygdala reactivity might lead to negative bias during emotional processing that can be reversed by antidepressant drug treatment. However, little is known on how N-methyl-d-aspartate (NMDA) receptor antagonism with ketamine as a novel target modulate stimulation. Using functional magnetic resonance imaging (fMRI) and resting-state fMRI (rsfMRI), we assessed amygdalo-hippocampal at baseline pharmacological stimulation (intravenous bolus of 0.12 mg/kg, followed continuous infusion...