A5050503083- Psychedelics and Drug Studies
- Functional Brain Connectivity Studies
- Treatment of Major Depression
- Advanced MRI Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Biochemical Analysis and Sensing Techniques
- Neuroscience and Neuropharmacology Research
- Chemical synthesis and alkaloids
- Tryptophan and brain disorders
- Mental Health Research Topics
- Anesthesia and Neurotoxicity Research
- Cannabis and Cannabinoid Research
- Sleep and Wakefulness Research
- Diet and metabolism studies
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Medical Imaging Techniques and Applications
- Complementary and Alternative Medicine Studies
- Forensic Toxicology and Drug Analysis
- Memory and Neural Mechanisms
- Anesthesia and Sedative Agents
- Metabolomics and Mass Spectrometry Studies
- Advanced Neuroimaging Techniques and Applications
- EEG and Brain-Computer Interfaces
- Olfactory and Sensory Function Studies
- Health, Environment, Cognitive Aging
University of Zurich
2016-2025
University Hospital of Zurich
2012-2024
ETH Zurich
1992-2024
Ohio State University Hospital
2024
The Ohio State University
2024
University Psychiatric Hospital
2014-2024
Advanced Imaging Research (United States)
2022
The University of Texas Southwestern Medical Center
2022
Swiss Paraplegic Center
2022
MSB Medical School Berlin
2022
Increasing preclinical and clinical evidence underscores the strong rapid antidepressant properties of glutamate-modulating NMDA receptor antagonist ketamine. Targeting glutamatergic system might thus provide a novel molecular strategy for treatment. Since glutamate is most abundant major excitatory neurotransmitter in brain, pathophysiological changes signaling are likely to affect neurobehavioral plasticity, information processing large-scale functional brain connectivity underlying...
Ayahuasca is a plant-based decoction native to Amazonia, where it has long history of use in traditional medicine. Contemporary ritual ayahuasca been expanding throughout the world for mental health purposes, and spiritual personal growth. Although researchers have conducting clinical trials observational studies reporting medical psychological benefits, most these do not report ayahuasca's immediate or medium-term adverse effects, so are underrepresented literature. With expansion...
Significance Social cognition critically impacts the development, progression, and treatment of psychiatric disorders. However, social skills are insufficiently targeted by current approaches. By applying a multimodal brain imaging strategy, present study demonstrated importance serotonin 2A/1A receptor system in modulation exclusion processing. Understanding biochemical underpinnings rejection experience is important for increasing our knowledge about social/emotional processing related...
Meditation and psychedelics have played key roles in humankind's search for self-transcendence personal change. However, neither their possible synergistic effects, nor related state trait predictors been experimentally studied. To elucidate these issues, we administered double-blind the model psychedelic drug psilocybin (315 μg/kg PO) or placebo to meditators (n = 39) during a 5-day mindfulness group retreat. Psilocybin increased meditation depth incidence of positively experienced...
Ayahuasca is a psychoactive Amazonian brew which has emerging data indicating that it antidepressant and anxiolytic properties. This paper uses from the Global Project (GAP), was undertaken across 2017–2020 involved 11912 people, to examine perceived effects of consumption on affective symptoms. The study focused subsample reporting depression or anxiety diagnoses at time consumption. Of participants (n = 1571) 1125) consuming Ayahuasca, 78% reported their either 'very much' improved (46%),...
There is growing scientific evidence for the therapeutic benefits of Amazonian plant-based psychedelic "ayahuasca" neuropsychiatric disorders such as depression and anxiety. However, there are certain challenges when incorporating botanical ayahuasca into biomedical research clinical therapy environments. Formulations inspired by ayahuasca, which contain specific standardized active components, a potential remedy.
Rationale: Psychedelic research re-emerged from a period of suppression into the so-called psychedelic renaissance. In parallel, most media reporting has shifted overstatement risks psychedelics to overly positive hype. As empirical evidence is more equivocal than frequently portrayed, conclusions about effectiveness should be considered preliminary. Poor science communication psychedelics’ therapeutic potential may lead participants or patients feel misled and policy decisions misinformed....
Abstract In this study, for the first time, we explored a dataset of functional magnetic resonance images collected during focused attention and open monitoring meditation before after five-day psilocybin-assisted retreat using recently established approach, based on Mapper algorithm from topological data analysis. After generating subject-specific maps two groups (psilocybin vs. placebo, 18 subjects/group) experienced meditators, organizational principles were uncovered graph tools,...
Significance Major depressive disorder is a significant contributor to the global burden of disease, affecting 350 million people according an estimation World Health Organization. Today, no valid biomarkers depression, which could predict efficacy certain treatment in group patients, exist. Sleep deprivation effective and rapid-acting antidepressive treatment. However, biomechanism this effect largely unknown. This study shows effects sleep on human brain functional connectivity alterations...
Increased amygdala reactivity might lead to negative bias during emotional processing that can be reversed by antidepressant drug treatment. However, little is known on how N-methyl-d-aspartate (NMDA) receptor antagonism with ketamine as a novel target modulate stimulation. Using functional magnetic resonance imaging (fMRI) and resting-state fMRI (rsfMRI), we assessed amygdalo-hippocampal at baseline pharmacological stimulation (intravenous bolus of 0.12 mg/kg, followed continuous infusion...
Increased sleep time and intensity quantified as low-frequency brain electrical activity after loss demonstrate that need is homeostatically regulated, yet the underlying molecular mechanisms remain elusive. We here metabotropic glutamate receptors of subtype 5 (mGluR5) contribute to machinery governing sleep-wake homeostasis. Using positron emission tomography, magnetic resonance spectroscopy, electroencephalography in humans, we find increased mGluR5 availability tightly correlates with...
Purpose The transverse relaxation times T 2 of 17 metabolites in vivo at 3T is reported and region specific differences are addressed. Methods An echo‐time series protocol was applied to one, two, or three volumes interest with different fraction white gray matter including a total number 106 healthy volunteers acquiring 128 spectra. data were fitted the 2D fitting tool ProFit2, which included individual line shape modeling for all allowed calculation 28 moieties metabolites. Results 10...
Distraction and rumination are distinct response styles that determine how an individual deals with negative thoughts feelings. Rumination is accompanied by elevated self-focus, which associated increased resting state functional connectivity decreased reactivity within the default mode network. Interestingly, NMDA receptor antagonist ketamine reduces in this network, while its effects on blood oxygenation level-dependent (BOLD) responses during stimulus perception not known. Ketamine might...
Recently, the Amazonian plant medicine “ayahuasca”—containing psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective other mental health disorders. Although ayahuasca ingestion is considered safe, its pharmacokinetics/pharmacodynamics tolerability profile pose some challenges may limit clinical applicability vulnerable patient populations. While overdosing admixture of...
Psychedelics are psychoactive substances that receive renewed interest from science and society. Increasing empirical evidence shows the effects of psychedelics associated with alterations in biochemical processes, brain activity, lived experience. Still, how these different levels relate remains subject to debate. The current literature presents two influential views on relationship between psychedelic molecule, neural events, experience: integration view pluralistic view. main aim this...