A5039154815- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Sleep and Work-Related Fatigue
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Coffee research and impacts
- Traumatic Brain Injury and Neurovascular Disturbances
- Epilepsy research and treatment
- Glioma Diagnosis and Treatment
- Spine and Intervertebral Disc Pathology
- Diet and metabolism studies
- Neural dynamics and brain function
- Pituitary Gland Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Neuroscience of respiration and sleep
- Cerebrospinal fluid and hydrocephalus
- Cerebrovascular and Carotid Artery Diseases
- Functional Brain Connectivity Studies
- Eating Disorders and Behaviors
- Meningioma and schwannoma management
- Electromagnetic Fields and Biological Effects
- Spinal Fractures and Fixation Techniques
- Musculoskeletal pain and rehabilitation
- Biomedical and Chemical Research
University of Zurich
2016-2025
Institute of Pharmacology
2006-2025
Swiss Integrative Center for Human Health
2008-2023
ETH Zurich
2012-2023
University Hospital of Zurich
2005-2022
Kantonsspital Aarau
2007-2020
Zürcher Fachhochschule
2016
Frankston Hospital
2015
Paul Scherrer Institute
1999-2012
Novartis Institutes for BioMedical Research
2012
Evidence comparing the effectiveness of surgical and conservative treatment symptomatic lumbar disc herniation is controversial. We sought to compare short-term long-term in sciatica symptom severity quality life patients with a routine clinical setting.A prospective cohort study practice registry consisting 370 patients. Outcome measures were North American Spine Society questionnaire 36-Item Short-Form Health Survey assess patient-reported back pain, physical function, neurogenic symptoms...
SUMMARY Usage of mobile phones is rapidly increasing, but there limited data on the possible effects electromagnetic field (EMF) exposure brain physiology. We investigated effect EMF vs. sham control waking regional cerebral blood flow (rCBF) and sleep electroencephalogram (EEG) in humans. In Experiment 1, positron emission tomography (PET) scans were taken after unilateral head to 30‐min pulse‐modulated 900 MHz (pm‐EMF). 2, night‐time was polysomnographically recorded exposure....
Caffeine is the most widely used stimulant in Western countries. Some people voluntarily reduce caffeine consumption because it impairs quality of their sleep. Studies mice revealed that disruption sleep after mediated by blockade adenosine A2A receptors. Here we show humans (1) habitual associated with reduced self-rated caffeine-sensitive individuals, but not caffeine-insensitive individuals; (2) distribution distinct c.1083T>C genotypes receptor gene (ADORA2A) differs between and...
Slow, rhythmic oscillations (<5 Hz) in the sleep electroencephalogram may be a sign of synaptic plasticity occurring during sleep. The oscillations, referred to as slow-wave activity (SWA), reflect need and intensity. amount SWA is homeostatically regulated. It enhanced after loss declines Animal studies suggested that genetically controlled, yet physiological mechanisms remain unknown. Here we show humans genetic variant adenosine deaminase, which associated with reduced metabolism...
Homeostatic sleep regulation in habitual short sleepers (sleep episode < 6 h, n = 9) and long (> 9 7) was investigated by studying their structure electroencephalogram (EEG) during baseline conditions after prolonging waking time 24 h. In each episode, total > 3 h longer the than sleepers. Sleep deprivation decreased latency rapid eye movement (REM) density REM more The enhancement of EEG slow-wave activity (SWA; spectral power 0.75-4.5 Hz range) non-REM loss larger (47%) (19%)....
The Psychomotor Vigilance Task (PVT) is one of the leading assays sustained vigilant attention in sleep research and highly sensitive to effects loss. Even though PVT widely used deprivation studies, little known about performance patients suffering from sleep-wake disorders. We aimed quantify impact disorders on outcome measures examine whether can distinguish between healthy controls with three different that express excessive daytime sleepiness.We compared data 143 67 age- gender-matched...
Abstract Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) (NREMS) EEG delta (δ-)power are widely used as proxy for a homeostatic process. Here, we noted frequency increases δ-waves sleep-deprived mice, prompting us to re-evaluate how slow-wave characteristics relate prior sleep-wake history. We identified two classes of δ-waves; one responding deprivation with high initial power and fast, discontinuous decay during recovery (δ2) another unrelated time-spent-awake slow, linear...
Background and Purpose: The purpose of this study was to assess nationwide incidence outcomes aneurysmal subarachnoid hemorrhage (aSAH). Swiss SOS (Swiss Study on Subarachnoid Hemorrhage) established in 2008 offers the unique opportunity provide data from point care a level. Methods: All patients with confirmed admitted between January 1, 2009 December 31, 2014, within Switzerland were recorded prospective registry. Incidence rates calculated based time-matched population data. Admission...
The pathophysiology of peri-lesion boundary zones in acute brain injury is highly dynamic, and it now clear that spreading-depression-like events occur frequently areas cerebral cortex adjacent to contusions the injured human brain. An automated method assay microdialysate from 11 patients with intracranial haematomas requiring surgery was used. Perfusate (2 μL/min) flowed directly into a flow-injection system for glucose lactate at intervals typically 30 secs each. Four channels...
Abstract We investigated the effects of radio frequency electromagnetic fields (RF EMF) similar to those emitted by mobile phones on waking regional cerebral blood flow (rCBF) in 12 healthy young men. Two types RF EMF exposure were applied: a ‘base‐station‐like’ and ‘handset‐like’ signal. Positron emission tomography scans taken after 30 min unilateral head pulse‐modulated 900 MHz (10 g tissue‐averaged spatial peak‐specific absorption rate 1 W/kg for both conditions) sham control. observed...
Study Objectives:To examine whether vigilant attention and sleepiness develop differently during prolonged wakefulness in young older men.
To investigate rapid eye movement (REM) sleep regulation, eight healthy young men were deprived of REM for three consecutive nights. In a three-night control deprivation (CD) session 2 wk later, the subjects repeatedly awakened from non-REM in an attempt to match awakenings during (RD) During RD nights number interruptions required prevent increased within and across was reduced 9.2% baseline (CD nights: 80.7%) rose 140.1% first recovery night. gave rise changes EEG power spectra sleep....
Summary To establish a dose–response relationship between the strength of electromagnetic fields (EMF) and previously reported effects on brain, we investigated influence EMF exposure by varying signal intensity in three experimental sessions. The head 15 healthy male subjects was unilaterally exposed for 30 min prior to sleep pulse‐modulated (GSM handset like signal) with 10 g‐averaged peak spatial specific absorption rate (1) 0.2 W kg –1 , (2) 5 or (3) sham double‐blind, crossover design....