A5038087613- Circadian rhythm and melatonin
- Sleep and Wakefulness Research
- Neuroscience of respiration and sleep
- Photoreceptor and optogenetics research
- Neural dynamics and brain function
- Spaceflight effects on biology
- Electromagnetic Fields and Biological Effects
- Advanced Chemical Sensor Technologies
- Genetics, Aging, and Longevity in Model Organisms
- Endoplasmic Reticulum Stress and Disease
- Respiratory Support and Mechanisms
- Nerve injury and regeneration
- Neurobiology and Insect Physiology Research
- Sleep and related disorders
- Autophagy in Disease and Therapy
UK Dementia Research Institute
2020-2024
Imperial College London
2020-2024
University of Lausanne
2017-2021
Swiss National Science Foundation
2019
Haute École Pédagogique du Canton de Vaud
2019
Abstract Sleep-wake driven changes in non-rapid-eye-movement sleep (NREM) (NREMS) EEG delta (δ-)power are widely used as proxy for a homeostatic process. Here, we noted frequency increases δ-waves sleep-deprived mice, prompting us to re-evaluate how slow-wave characteristics relate prior sleep-wake history. We identified two classes of δ-waves; one responding deprivation with high initial power and fast, discontinuous decay during recovery (δ2) another unrelated time-spent-awake slow, linear...
Sleep depriving mice affects clock-gene expression, suggesting that these genes contribute to sleep homeostasis. The mechanisms linking extended wakefulness expression are, however, not well understood. We propose CIRBP play a role because its rhythmic is i) sleep-wake driven and ii) necessary for high-amplitude in vitro. therefore expect Cirbp knock-out (KO) exhibit attenuated sleep-deprivation-induced changes consequently differ their homeostatic regulation. Lack of indeed blunted the...
In the mouse, Period-2 ( Per2 ) expression in tissues peripheral to suprachiasmatic nuclei (SCN) increases during sleep deprivation and at times of day when animals are predominantly awake spontaneously, suggesting that circadian sleep-wake distribution directly contributes daily rhythms . We found support for this hypothesis by recording state alongside PER2 bioluminescence freely behaving mice, demonstrating spontaneous waking decreases sleep. The temporary reinstatement...
Although brain temperature has neurobiological and clinical importance, it remains unclear which factors contribute to its daily dynamics what extent. Using a statistical approach, we previously demonstrated that hourly values co-varied strongly with time spent awake (Hoekstra et al., 2019). Here develop make available mathematical tool simulate predict cortical in mice based on 4-s sleep–wake sequence. Our model estimated remarkable precision accounted for 91% of the variance three factors:...
Circadian regulation and temperature dependency are important orchestrators of molecular pathways. How the integration between these two drivers is achieved, not understood. We monitored circadian- temperature-dependent effects on transcription dynamics cold-response protein RNA Binding Motif 3 (Rbm3). Temperature changes in mammalian master circadian pacemaker, suprachiasmatic nucleus (SCN), induced Rbm3 regulated its periodicity, whereas core clock gene Per2 was unaffected. induction...
Abstract Autophagy is a vital catabolic process responsible for the degradation of cytosolic components, playing key role in cellular homeostasis and survival. At synapses, autophagy crucial regulating neuronal activity utilizes specialized machinery. While considerable progress has been made understanding initiation autophagosome formation, mechanisms governing clearance autophagosomes from synaptic sites remain poorly understood. Here, we identify novel pathway which astrocytes actively...
Abstract Sleep depriving mice affects clock gene expression, suggesting that these genes partake in sleep homeostasis. The mechanisms linking wakefulness to expression are, however, not well understood. We propose CIRBP because its rhythmic is i) sleep-wake driven and ii) necessary for high-amplitude vitro . therefore expect Cirbp knock-out (KO) exhibit attenuated sleep-deprivation (SD) induced changes consequently differ their homeostatic regulation. Lack of indeed blunted the SD-incurred...
Abstract While brain temperature is of neurobiological and clinical importance, it still unclear which factors contribute to its daily dynamics what degree. We recorded cortical in mice alongside sleep-wake state during 4 days including a 6h sleep deprivation, developed mathematical tool simulate based on the sequence. The model estimated with remarkable precision accounting for 91% variance three main sequence most (74%) time-of-day (‘circadian’) least (9%). As third factor, prior wake...
Abstract Sleep-wake driven changes in NREM sleep (NREMS) EEG delta (δ: ∼0.75-4.5Hz) power are widely used as proxy for a homeostatic process. We noted frequency increases δ-waves sleep-deprived (SD) mice, prompting us to re-evaluate how slow-wave characteristics relate prior sleep-wake history. discovered two types of δ-waves; one responding SD with high initial and fast, discontinuous decay (δ2: ∼2.5-3.5Hz) another unrelated time-spent-awake slow, linear decays (δ1: ∼0.75-1.75Hz). Human...
Abstract In the mouse, Period-2 ( Per2 ) expression in tissues peripheral to suprachiasmatic nuclei (SCN) increases during sleep deprivation and at times of day when animals are predominantly awake spontaneously, suggesting that circadian sleep-wake distribution directly contributes daily rhythms . We found support for this hypothesis by recording state alongside PER2 bioluminescence freely behaving mice, demonstrating spontaneous waking decreases sleep. The temporary reinstatement...