A5073890309- Advanced Neuroimaging Techniques and Applications
- Cerebral Palsy and Movement Disorders
- Cardiac Structural Anomalies and Repair
- Functional Brain Connectivity Studies
- MRI in cancer diagnosis
- Dementia and Cognitive Impairment Research
- Elasticity and Material Modeling
- Cerebrovascular and Carotid Artery Diseases
- Traumatic Brain Injury Research
- Cardiovascular Function and Risk Factors
- Neural dynamics and brain function
- Advanced MRI Techniques and Applications
- Acute Ischemic Stroke Management
- Tracheal and airway disorders
- Cardiovascular Health and Disease Prevention
- Neurobiology of Language and Bilingualism
- Balance, Gait, and Falls Prevention
- Pelvic floor disorders treatments
- Alzheimer's disease research and treatments
- Optical Imaging and Spectroscopy Techniques
- EEG and Brain-Computer Interfaces
- Obstructive Sleep Apnea Research
- Eicosanoids and Hypertension Pharmacology
- Traumatic Brain Injury and Neurovascular Disturbances
- Voice and Speech Disorders
Western University
2016-2025
Robarts Clinical Trials
2018-2023
University of Tehran
2009
Plasma biomarkers of Alzheimer disease (AD), neuroinflammation, and neurodegeneration are increasingly being used in clinical trials for diagnosis monitoring dementia. However, their association with longitudinal structural brain MRI changes, an important outcome measure across neurodegenerative cerebrovascular diseases, is less known. We investigated how baseline plasma reflect markers progression over time patients diseases. This cohort study included from the Ontario Neurodegenerative...
Abstract Background and purpose The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, in the presence white matter hyperintensities (WMHs) cognitive motor impairments seem to be aggravated. However, role WMHs predicting accelerating symptom worsening remains controversial. objective was investigate whether location segmental WMH burden at baseline predict declines PD after 2 years. Methods Ninety‐eight older adults followed longitudinally from Ontario...
The processing of brain diffusion tensor imaging (DTI) data for large cohort studies requires fully automatic pipelines to perform quality control (QC) and artifact/outlier removal procedures on the raw DTI prior calculation parameters. In this study, three pipelines, each complying with general ENIGMA framework, were designed by uniquely combining multiple image software tools. Different QC based RESTORE algorithm, DTIPrep protocol, a combination both methods compared using simulated ground...
Background Cerebral small vessel disease is associated with higher ratios of soluble-epoxide hydrolase derived linoleic acid diols (12,13-dihydroxyoctadecenoic [DiHOME] and 9,10-DiHOME) to their parent epoxides (12(13)-epoxyoctadecenoic [EpOME] 9(10)-EpOME); however, the relationship has not yet been examined in stroke. Methods Results Participants mild moderate stroke or large were selected based on clinical imaging criteria. Metabolites quantified by ultra-high-performance liquid...
Alterations in tissue microstructure normal-appearing white matter (NAWM), specifically measured by diffusion tensor imaging (DTI) fractional anisotropy (FA), have been associated with cognitive outcomes following stroke. The purpose of this study was to comprehensively compare conventional DTI measures NAWM diverse vascular brain lesions people cerebrovascular disease (CVD) and examine associations between FA risk factors. metrics including mean diffusivity (MD), axial (AD), radial (RD)...
Introduction: Mild cognitive impairment (MCI) affects obstacle negotiation capabilities, potentially increasing the risk of falls in older adults. However, it is unclear whether smaller brain volumes typically observed individuals with MCI are related to hazardous this population. Methods: A total 93 participants (71.9 ± 5.36 years age; = 53/control 40) from Gait and Brain Study were analyzed. Gray matter (GM) frontal, temporal, parietal lobes entered analysis. performance was recorded using...
Acute change in gait speed while performing a mental task [dual-task cost (DTC)], and hyperintensity magnetic resonance imaging signals white matter are both important disability predictors older individuals with history of stroke (poststroke). It is still unclear, however, whether DTC associated overall volume from specific major brain regions poststroke.This cohort study total 123 (69 ± 7 years age) participants were included the Ontario Neurodegenerative Disease Research Initiative....
For studying cardiac mechanics, hyperelastic anisotropic computational models have been developed which require the tissue and parameters. These parameters are obtained by samples mechanically testing. The validity of such limited to specific sample only. They not adaptable for pathological tissues commonly associated with microstructure alterations. To investigate a novel approach is proposed model hyperelasticity anisotropy. This various microstructural constituent's distributions in...
In this paper, a new numerical method to solve the time-domain electric field integral equation (TD-EFIE) for arbitrary conducting thin wire antennas in free space is presented. formulation which called of moment (TD-MoM), triangular spatial and temporal basis functions are used. By employing Galerkin's domain point matching time domain, it shown that integrals involved can be evaluated analytically parallel thin-wire antennas. This advantage TD-MoM decreases computation drastically. The...
Altered white matter (WM) tract integrity may contribute to mild cognitive impairment (MCI) and gait abnormalities.The purpose of this study was determine whether diffusion tensor imaging (DTI) metrics were altered in specific portions WM tracts people with MCI speed variations associated the DTI metric changes.DTI acquired 44 40 cognitively normal elderly controls (CNCs). Fractional anisotropy (FA) radial diffusivity (RD) measured along 18 major brain using probabilistic tractography. The...
Objective The use of computer simulation to develop a high‐fidelity model has been proposed as novel and cost‐effective alternative help guide therapeutic intervention in sleep apnea surgery. We describe based on patient‐specific anatomy obstructive (OSA) subjects wherein the percentage sites upper airway collapse are compared findings drug‐induced endoscopy (DISE). Study Design Basic science generation. Methods Three‐dimensional finite element techniques were undertaken for development...
Lung cancer is one of the leading causes death in men and women. External Beam Radiation Therapy (EBRT) a commonly used primary treatment for condition. A major challenge with such treatments delivery sufficient radiation dose to lung tumor while ensuring that surrounding healthy parenchyma receives only minimal dose. This can be achieved by coupling EBRT respiratory computer models which predict tumour location as function phase during breathing cycle<sup>1</sup>. The diaphragm muscle...
Computational models are effective tools to study cardiac mechanics under normal and pathological conditions. They can be used gain insight into the physiology of heart these conditions while they adaptable computer assisted patient-specific clinical diagnosis therapeutic procedures. Realistic incorporate tissue active/passive response in conjunction with hyperelasticity anisotropy. Conventional formulation such leads mathematically-complex problems usually solved by custom-developed...
Cardiac ischemic injuries can be classified into two main categories: reversible and irreversible. Treatment of damages is possible through revascularization therapies. Clinically, it quite vital to determine the reversibility local efficiency using accurate diagnostics techniques. For this purpose, a number imaging techniques have been developed. To our knowledge, while some these are capable assessing tissue viability which believed correlated with reversibility, none them providing...
It is clinically vital to devise a technique evaluate regional functionality of the myocardium in order determine extent and intensity local damage cardiac tissue caused by ischemic injuries. Such can potentially enable cardiologists discriminate between reversible irreversible injuries appropriate revascularization therapy case lesions. The founded on premise that sufficient contraction force generated be regarded as direct reliable criterion for analysis healthy functionality. To this end,...
There is a strong relationship between cerebrovascular disease and dementia. Statistically, ∼10% of stroke patients have prior history dementia while will develop later. Vascular cognitive impairment (VCI) clinical condition that involves accompanied by at least one impaired domain. A wide range cerebral tissue injuries indicate the presence vascular including lesions, white matter hyperintensities, lacunar infarcts. Differentiation these anomalies challenging using typical signs symptoms....