A5072024709- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Neurological diseases and metabolism
- Meningioma and schwannoma management
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neurological disorders and treatments
- Pituitary Gland Disorders and Treatments
- Neurological Disease Mechanisms and Treatments
- Neurogenetic and Muscular Disorders Research
- Cellular transport and secretion
- Cerebrovascular and genetic disorders
- RNA regulation and disease
- Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Cancer, Hypoxia, and Metabolism
- Schizophrenia research and treatment
- Multiple Sclerosis Research Studies
- Neurofibromatosis and Schwannoma Cases
- Vasculitis and related conditions
- Brain Metastases and Treatment
- Advanced Neuroimaging Techniques and Applications
St. Michael's Hospital
2016-2025
University of Toronto
2016-2025
Canada Research Chairs
2016-2025
Pennsylvania State University
2024
St Michaels Hospital
2007-2024
St Michael’s Hospital
2018-2024
Unity Health Toronto
2021-2024
Menéndez Pelayo International University
2023
Hospital Infantil Universitario Niño Jesús
2023
Clínica CES
2021-2022
Abstract Familial parkinsonism and dementia with cortical subcortical Lewy bodies is uncommon, no genetic defect has been reported in the previously described sibships. We present a Spanish family autosomal dominant parkinsonism, dementia, visual hallucinations of variable severity. The postmortem examination showed atrophy substantia nigra, lack Alzheimer pathology, numerous which were immunoreactive to α‐synuclein ubiquitin areas. Sequencing gene novel, nonconservative E46K mutation...
This is a clinicopathologic study of prospective, clinic-based cohort patients with frontotemporal dementia (FTD)/Pick complex, who were followed to autopsy. A total 60 the clinical syndromes behavioural variant FTD (FTD-bv) (n = 32), primary progressive aphasia (PPA) 22), corticobasal degeneration syndrome (CBDS) 4) and supranuclear palsy (PSP) 2) at onset, referred cognitive neurology clinic had subsequent post-mortem examination included. The most common histological variety was motor...
Eight patients with a homogeneous syndrome of progressive symmetric spinobulbar spasticity were studied. Clinical features limited to those associated dysfunction the descending motor tracts and included spastic quadriparesis, pseudobulbar affect, dysarthria, hyper-reflexia bilateral Babinski signs. Lower neuron findings absent higher cognitive function preserved. Median age onset was 50.5 yrs median disease duration 19 Neuropathologic (including morphometric analysis) in single autopsied...
To analyze the association of polymorphisms in tau gene with pathologically confirmed corticobasal degeneration (CBD).The authors previously described an extended haplotype (H1) that covers human and is associated development progressive supranuclear palsy (PSP). The now extend this analysis to CBD, a neurodegenerative condition clinical neuropathologic similarities PSP. Like PSP, CBD accumulation aggregates containing 4-repeat isoforms tau. Because difficulty diagnosis only analyzed cases...
Accumulation of the DNA/RNA binding protein fused in sarcoma as cytoplasmic inclusions neurons and glial cells is pathological hallmark all patients with amyotrophic lateral sclerosis mutations FUS well several subtypes frontotemporal lobar degeneration, which are not associated mutations. The mechanisms leading to inclusion formation sarcoma-associated neurodegeneration only poorly understood. Because belongs a family proteins known FET, also includes Ewing's TATA-binding protein-associated...
Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection who would benefit from adjuvant radiotherapy to delay recurrence. We aimed develop an individualized prediction model risk combining clinical and molecular factors meningioma. Methods DNA methylation profiles clinically annotated samples across multiple institutions were used a methylome 5-year...
<b><i>Objective:</i></b> To provide evidence for the hypothesis that corticobasal degeneration syndrome (CBDs) overlaps significantly with primary progressive aphasia and frontotemporal dementia, CBDs is part of Pick complex. <b><i>Background:</i></b> Corticobasal has been mainly described as a movement disorder, but cognitive impairment also increasingly noted. <b><i>Methods:</i></b> Thirty-five cases clinically diagnosed were followed-up clinical, neuropsychological, neuroimaging...
Anti-inflammatory drugs have been suggested as a possible treatment for Alzheimer's disease (AD). The association of immune proteins and immune-competent microglial cells with senile plaques (SP) in both AD normal aging suggests that these may be able to modify the course AD, either by interfering SP formation or suppressing inflammation associated SP. We compared postmortem brain tissue from elderly, nondemented, arthritic patients history chronic nonsteroidal anti-inflammatory drug (NSAID)...
Through an international consortium, we have collected 37 tau- and TAR DNA-binding protein 43 (TDP-43)-negative frontotemporal lobar degeneration (FTLD) cases, present here the first comprehensive analysis of these cases in terms neuropathology, genetics, demographics clinical data. 92% (34/37) had fused sarcoma (FUS) pathology, indicating that FTLD-FUS is important FTLD subtype. This collection specifically focussed on aFTLD-U one three recently defined subtypes FTLD-FUS. The subtype...
We present three cases of primary progressive aphasia (PPA) with Pick-variant pathology to support a hypothesis an underlying nosologic relatedness. Neuropathologic examination demonstrated focal brain atrophy corresponding neuronal loss and gliosis, accompanied by superficial spongiosis. Specific histologic findings were ballooned neurons (Pick cells) in the atrophic areas, two cases, Pick bodies. They immunoreactive for tau. In contrast classic Pick9s disease, there no bodies hippocampus....
Perikaryal collections of intermediate filaments have been described in the anterior horn motoneurons patients with amyotrophic lateral sclerosis (ALS), but these inclusions generally considered rare and mainly associated familial form ALS. Using monoclonal antibody NF2FII, which recognizes phosphorylated neurofilament epitopes, we showed that focal neurofilaments were a characteristic finding sporadic as well ALS; they present seven nine ALS patients, none control spinal cords. These...
This study examined the experiential factors and interacting vulnerabilities that contribute to development of posttraumatic stress disorder (PTSD) in children adolescents.Of 100 consecutive referrals an inner-city child adolescent psychiatry clinic, 59 had experienced a trauma qualified as precipitant PTSD. For those with trauma, ages ranged from 3 18 years (mean=9.9, SD=4.10); 39 (66%) were males. The authors used series multiple regression analyses examine contribution demographic...
Six sporadic cases of dementia with lobar atrophy and neuronal cytoplasmic inclusions (Pick's disease) could be separated into two groups on the basis involvement subcortical structures, distribution histochemical, immunochemical, ultrastructural characteristics inclusions, possibly age at onset. The first group (classic) was characterized by predominantly cortical presence in hippocampus neocortex argyrophilic inclusion bodies that reacted a monoclonal antibody against neurofilament...
Corticobasal degeneration is a sporadic form of tauopathy, involving the cerebral cortex and extrapyramidal motor system. A series affected subjects was genotyped for set genetic markers along tau protein gene. specific haplotype significantly overrepresented in patients versus controls. This same already reported association with progressive supranuclear palsy. These data show that corticobasal palsy, addition to several clinical, pathological, molecular features, may have background.
Hippocampal sclerosis is the sole abnormality found in approximately 65% of all temporal lobe specimens resected for intractable epilepsy. Up to 27% en bloc lobectomy specimens, however, show no definitive pathological changes. The lateral amygdaloid nucleus from 8 consecutive patients who underwent whom hippocampal pathology was present and corresponding tissue with were subjected quantitative estimation neuronal density astrogliosis. As compared autopsy control subjects history...
• The pathologic correlates of increased signal in the white matter centrum ovale postmortem magnetic resonance imaging were investigated an unselected series 15 autopsies. Two types hyperintensities could be separated on basis size (10-mm cutoff): extensive and punctate. was large areas pallor with ill-defined margins, located central sparing subcortical U fibers both myelin axonal stains. Microscopically, these showed diffuse vacuolation significant reduction areal densities glial cells....
<b>Objective: </b> To determine the prevalence of α-synuclein (AS) aggregates in abdominopelvic autonomic plexuses general population and to evaluate relationship between this finding subsequent development neurologic dysfunction. <b>Methods: First, surgical specimens from 100 patients (ages 44 84) undergoing a wide resection an organ were examined by anti-AS immunostaining. Second, 16 (6 AS+ 10 randomly selected AS−) participated yearly double-blinded assessments. <b>Results: AS found 9%...
The relative contributions of vascular and degenerative pathology to dementia are unknown. We aim quantify the proportion explained by potentially preventable lesions.We systematically searched for population-based cohorts before February 2017 reporting clinicopathological data individuals with without dementia. calculated summary absolute risk comparing subjects pathology.We identified 10 studies comprising 2856 subjects. Vascular-type mixed respectively two three times more likely in...