David H. James

ORCID: 0000-0003-3951-9187
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About
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Research Areas
  • Neuroblastoma Research and Treatments
  • Metal Alloys Wear and Properties
  • High-Temperature Coating Behaviors
  • Cancer therapeutics and mechanisms
  • Surface Treatment and Coatings
  • Childhood Cancer Survivors' Quality of Life
  • Head and Neck Surgical Oncology
  • Pharmaceutical studies and practices
  • Beetle Biology and Toxicology Studies
  • Cancer-related Molecular Pathways
  • Congenital Diaphragmatic Hernia Studies
  • Hemiptera Insect Studies
  • Meningioma and schwannoma management
  • Advanced Breast Cancer Therapies
  • Acute Lymphoblastic Leukemia research
  • Neuroendocrine Tumor Research Advances
  • Metal and Thin Film Mechanics
  • Tribology and Wear Analysis
  • Clinical Reasoning and Diagnostic Skills
  • Testicular diseases and treatments
  • Materials Engineering and Processing
  • Endometriosis Research and Treatment
  • Diphtheria, Corynebacterium, and Tetanus
  • Parvovirus B19 Infection Studies
  • Chemotherapy-related skin toxicity

Australia New Zealand Gynaecological Oncology Group
2024

Swansea University
2021-2024

Columbia University
2022

Henry Ford Health System
2018

University of Alabama at Birmingham
2013

Atkins (United Kingdom)
1992

Metallisation (United Kingdom)
1980-1984

Associated Research (United States)
1975

University of Tennessee Health Science Center
1961-1968

University of Tennessee at Knoxville
1964-1968

Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection who would benefit from adjuvant radiotherapy to delay recurrence. We aimed develop an individualized prediction model risk combining clinical and molecular factors meningioma. Methods DNA methylation profiles clinically annotated samples across multiple institutions were used a methylome 5-year...

10.1093/neuonc/noz061 article EN public-domain Neuro-Oncology 2019-04-12

Vincristine sulfate and cyclophosphamide were administered concurrently to nine consecutive children with unresectable neuroblastomas. Objective tumor regression was observed in all complete remission obtained seven. The findings of this study indicate that the concurrent use vincristine can produce prolonged, symptom-free survival some also neuroblastomas will respond chemotherapy alone or followed by radiation therapy an extent allows surgical excision.

10.1001/jama.1965.03090150015003 article EN JAMA 1965-10-11

In a study of 117 patients under the age 20 with acute leukemia, vincristine (VCR), at 2 mg. per square meter body surface week, produced complete remissions in 55 cent and partial 15 cent. The drug also induced second remissions. Patients entering remission VCR were randomly allocated to maintenance therapy or placebo. median duration was short: 9 weeks for compared 6 probability serious neurological toxicity computed according time exposure VCR, based on supposition that not used therapy,...

10.1002/cpt196673332 article EN Clinical Pharmacology & Therapeutics 1966-05-01

10.1016/s0022-3476(64)80343-7 article EN The Journal of Pediatrics 1964-04-01

10.1016/s0022-3476(53)80080-6 article EN The Journal of Pediatrics 1953-07-01

THE ANTIBIOTIC, dactinomycin, and the alkaloid, vincristine sulfate, have each produced objective tumor regression in children with a variety of malignant neoplasms.<sup>1</sup>The best responses to dactinomycin occurred cases Wilms' rhabdomyosarcoma, although has occasionally been observed lymphoma, neuroblastoma, other neoplasms. The antitumor spectrum sulfate included lymphomas, tumor, Ewing's sarcoma, retinoblastoma, liposarcoma. Dactinomycin acts by binding guanine moiety...

10.1001/jama.197.12.1043 article EN JAMA 1966-09-19

10.1016/s0022-3476(61)80085-1 article EN The Journal of Pediatrics 1961-08-01

THE ANTIBIOTIC, dactinomycin, and the alkaloid, vincristine sulfate, have each produced objective tumor regression in children with a variety of malignant neoplasms.<sup>1</sup>The best responses to dactinomycin occurred cases Wilms' rhabdomyosarcoma, although has occasionally been observed lymphoma, neuroblastoma, other neoplasms. The antitumor spectrum sulfate included lymphomas, tumor, Ewing's sarcoma, retinoblastoma, liposarcoma. Dactinomycin acts by binding guanine moiety...

10.1001/jama.1966.03110120149043 article EN JAMA 1966-09-19

Summary The systematic application of guidelines derived from the British National Formulary resulted in a substantial reduction amount and frequency medication used two hospitals for mentally handicapped.

10.1192/bjp.142.2.163 article EN The British Journal of Psychiatry 1983-02-01

Ovarian cancer (OC) is amongst the most lethal of common cancers in women. Lacking specific symptoms early stages, OC predominantly diagnosed late when disease has undergone metastatic spread and chemotherapy relied on to prolong life. Platinum-based therapies are preferred although many tumors respond initially, emergence platinum-resistance occurs majority cases after which prognosis very poor. Upregulation DNA damage pathways a feature platinum resistance with cyclin dependent kinases...

10.3389/fonc.2022.1014280 article EN cc-by Frontiers in Oncology 2022-11-25

DESPITE IMPROVEMENTS in surgical techniques and radiotherapy, malignant solid tumors of children have remained, by large, fatal diseases.<sup>1</sup>This poor outlook has not been modified appreciably the general improvement wellchild supervision that taken place recent years. During past decade several new drugs found to limited activity against various types childhood cancer. The use these drugs, however, for treatment inoperable most often reserved those whom every effort first made...

10.1001/jama.1964.03070080042016 article EN JAMA 1964-08-24

Endometrial cancer (EC) is the sixth most prevalent female globally and although high rates of success are achieved when diagnosed at an early stage, 5-year survival rate for cancers Stages II–IV below 50%. Improving patient outcomes will necessitate introduction novel therapies to clinic. Pan-cyclin-dependent kinase inhibitors (CDKis) have been explored as a range due their ability simultaneously target multiple key cellular processes, such cell cycle progression, transcription, DNA repair....

10.3390/cancers13051135 article EN Cancers 2021-03-06

Background: Student peer evaluation is widely used as a form of formative or summative in variety classroom settings; however, the utilization not well reported nursing literature part clinical process. Purpose: The purpose this pilot study was to examine relationships between student and faculty evaluations performance baccalaureate program. Participants consisted (n = 2) their students 23) enrolled first course pre-licensure specific research questions were: 1) Is there relationship...

10.5430/jnep.v3n8p170 article EN Journal of Nursing Education and Practice 2013-06-18

10.1016/s0022-3476(67)80219-1 article EN The Journal of Pediatrics 1967-11-01

SummaryThe paper considers the action of accelerators in zinc phosphate systems and other chemical additives which, conjunction with accelerators, influence nature coating processing conditions. It also nitrate nitrite accelerated systems, chlorate containing peroxy possible accelerators. The effect accelerator on structure is illustrated by scanning electron microscope, factors influencing choice system, hence type processes, equipment requirements are reviewed.

10.1080/00202967.1971.11870171 article EN Transactions of the IMF 1971-01-01

10.1016/s0022-3476(61)80141-8 article EN The Journal of Pediatrics 1961-06-01

SummaryElectric arc spraying utilises wire feedstock to produce strong, adherent coatings for a wide range of industrial applications. Coating properties are controlled by the material and parameters, care must be exercised in specifying since sprayed deposits inherently quite different metallurgically from more commonly experienced wrought or cast products. The significance coating adhesion problems its measurement discussed together with other important such as hardness residual stress....

10.1080/00202967.1982.11870604 article EN Transactions of the IMF 1982-01-01
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