Boris Krischek
A5017602363- Meningioma and schwannoma management
- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Moyamoya disease diagnosis and treatment
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Cerebrovascular and Carotid Artery Diseases
- Pituitary Gland Disorders and Treatments
- Neurofibromatosis and Schwannoma Cases
- Spinal Fractures and Fixation Techniques
- Neurosurgical Procedures and Complications
- Cerebrospinal fluid and hydrocephalus
- Connective tissue disorders research
- Cerebrovascular and genetic disorders
- Intracerebral and Subarachnoid Hemorrhage Research
- Aortic Disease and Treatment Approaches
- Atrial Fibrillation Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Acute Ischemic Stroke Management
- Chromatin Remodeling and Cancer
- Neurological Complications and Syndromes
- Facial Trauma and Fracture Management
- Bone Tumor Diagnosis and Treatments
- Spinal Hematomas and Complications
University Hospital Cologne
2013-2024
University of Cologne
2013-2024
University of Tübingen
2007-2023
Hôpital Kirchberg
2021
Gannan Medical University
2019
First Affiliated Hospital of Gannan Medical University
2019
Second Affiliated Hospital of Fujian Medical University
2019
Fujian Medical University
2019
Toronto Western Hospital
2013-2017
LVR-Klinik Köln
2016
Background Moyamoya disease is an idiopathic vascular disorder of intracranial arteries. Its susceptibility locus has been mapped to 17q25.3 in Japanese families, but the gene unknown. Methodology/Principal Findings Genome-wide linkage analysis eight three-generation families with moyamoya revealed (P<10-4). Fine mapping demonstrated a 1.5-Mb bounded by D17S1806 and rs2280147. We conducted exome index cases these results filtered through Ng criteria. There was variant p.N321S PCMTD1 p.R4810K...
Object While the use of endoscopic approaches has become increasingly accepted in resection pituitary adenomas, limited evidence exists regarding success this technique for patients with large and giant adenomas. This study reviews outcomes a cohort adenomas who underwent endonasal transsphenoidal surgery at authors' institution focuses on identifying factors that can predict extent hence aid developing guidelines indications versus open craniotomy to Methods The authors reviewed 487 sellar...
Abstract Background Variability in standard-of-care classifications precludes accurate predictions of early tumor recurrence for individual patients with meningioma, limiting the appropriate selection who would benefit from adjuvant radiotherapy to delay recurrence. We aimed develop an individualized prediction model risk combining clinical and molecular factors meningioma. Methods DNA methylation profiles clinically annotated samples across multiple institutions were used a methylome 5-year...
Abstract Meningiomas are mostly benign brain tumours, with a potential for becoming atypical or malignant. On the basis of comprehensive genomic, transcriptomic and epigenomic analyses, we compared meningiomas to ones. Here, show that majority primary ( de novo ) display loss NF2 , which co-occurs either genomic instability recurrent SMARCB1 mutations. These tumours harbour increased H3K27me3 signal hypermethylated phenotype, mainly occupying polycomb repressive complex 2 (PRC2) binding...
OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2 , SMARCB1 SMARCE1 TRAF7, KLF4, POLR2A BAP1 and members PI3K Hedgehog signaling pathways. Initial associations between clinical features subgroups been described, including location, grade, histology. However, further investigation using an expanded collection samples is needed to confirm previous findings, as well elucidate relationships not...
There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss H3K27me3 has been reported as prognostically unfavorable alteration meningiomas. We sought to independently evaluate the reproducibility prognostic value loss by immunohistochemistry (IHC) multicenter study.IHC staining analyses whole slides from 181 across three centers was performed. Staining analyzed dichotomization into retained immunoreactivity, using 3-tiered scoring...
Several studies have revealed that the gross-total resection (GTR) of malignant brain tumors has a significant influence on patient survival. Frequently, however, GTR cannot be achieved because borders between healthy and diseased tissue are blurred in infiltration zones tumors. Especially eloquent cortical areas, is frequently stopped before total removal to avoid causing neurological deficits. Interestingly, 5-aminolevulinic acid (5-ALA) been shown help visualize tumor intraoperatively...
The pathogenesis of intracranial aneurysm (IA) formation and rupture is complex, with significant contribution from genetic factors. We previously reported genome-wide association studies based on European discovery Japanese replication cohorts 5,891 cases 14,181 controls that identified five disease-related loci. These were testing genomic regions contained SNPs posterior probability (PPA) greater than 0.5 in the cohort. To identify additional IA risk loci, we pursued 14 loci PPAs cohort...
Few studies have evaluated the health-related quality of life (HRQoL) patients with meningiomas. Here, we report largest prospective, longitudinal cross-sectional cohort study HRQoL in meningiomas to date, order identify possible actionable determinants global HRQoL.Adults who had undergone resection a grade I intracranial meningioma and were routine follow-up at single large tertiary center underwent assessment using QLQ-C30 questionnaire administered opportunistically visits. Averaged...
Background Intrasaccular flow disruption represents a new paradigm in endovascular treatment of wide-necked bifurcation aneurysms. Objective To perform matched case–control study comparing complications and angiographic outcome using the Woven Endobridge (WEB) device stent-assisted coiling (SAC). Methods Sixty-six patients treated with WEB at three German tertiary care centers were included 66 SAC based on aneurysm location unruptured/ruptured status. Parameters retrospectively analysed...
Abstract In aneurysmal subarachnoid hemorrhage (aSAH), accurate diagnosis of aneurysm is essential for subsequent treatment to prevent rebleeding. However, detection proves be challenging and time-consuming. The purpose this study was develop evaluate a deep learning model (DLM) automatically detect segment aneurysms in patients with aSAH on computed tomography angiography. retrospective single-center study, three different DLMs were trained 68 79 treated (2016–2017) using...
Meningioma represents the most common primary brain tumor in adults. Recently several non-NF2 mutations meningioma have been identified and correlated with certain pathological subtypes, locations clinical observations. Alterations of cellular pathways due to these mutations, however, largely remained elusive. Here we report that Krueppel like factor 4 (KLF4)-K409Q mutation skull base meningiomas triggers a distinct phenotype. Transcriptomic analysis 17 samples revealed KLF4K409Q mutated...