A5045620537- Computational Drug Discovery Methods
- Multiple Sclerosis Research Studies
- Meningioma and schwannoma management
- SARS-CoV-2 and COVID-19 Research
- Chromatin Remodeling and Cancer
- Neurofibromatosis and Schwannoma Cases
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Peripheral Neuropathies and Disorders
- Ocular Oncology and Treatments
- interferon and immune responses
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and biological activity
- COVID-19 Clinical Research Studies
- RNA modifications and cancer
- Glioma Diagnosis and Treatment
- RNA Research and Splicing
- Head and Neck Surgical Oncology
- Glaucoma and retinal disorders
- Systemic Lupus Erythematosus Research
- Signaling Pathways in Disease
- Moyamoya disease diagnosis and treatment
- PI3K/AKT/mTOR signaling in cancer
- Vascular Malformations Diagnosis and Treatment
- Pituitary Gland Disorders and Treatments
Bahçeşehir University
2017-2025
Istanbul Technical University
2011-2015
Marmara University
2011-2015
Institute of Neurological Sciences
2012
Genetic Clues to Meningioma Meningiomas are the most common primary brain tumors in adults. Located within layer of tissue covering brain, these usually slow-growing and benign but can cause serious neurological complications. About half have mutations neurofibromin 2 gene ( NF2 ). To identify other genes that contribute meningioma pathogenesis, Clark et al. (p. 1077 , published online 24 January) performed genome sequence analysis on 300 tumors. fell into two general classes: located at...
Background and objective: We explored which clinical biochemical variables predict conversion from clinically isolated syndrome (CIS) to definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples 1047 CIS cases with at least two years’ follow-up. Age, sex, presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, cell count, 25-hydroxyvitamin D3 (25-OH-D), cotinine titres against...
OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2 , SMARCB1 SMARCE1 TRAF7, KLF4, POLR2A BAP1 and members PI3K Hedgehog signaling pathways. Initial associations between clinical features subgroups been described, including location, grade, histology. However, further investigation using an expanded collection samples is needed to confirm previous findings, as well elucidate relationships not...
We and others have identified mutually exclusive molecular subgroups of meningiomas; however, the implications this classification for clinical prognostication remain unclear. Integrated genomic epigenomic analyses implicate unique oncogenic processes associated with each subgroup, suggesting potential divergent courses. The aim study was to understand outcomes as could optimize treatment patients.We analyzed outcome data 469 meningiomas known including extent resection, postoperative...
Objective To identify a biomarker distinguishing patients who, despite primary progressive multiple sclerosis (PPMS) clinical course, may nonetheless benefit from immune therapy. Methods The presence or absence of both immunoglobulin (Ig) G and IgM oligoclonal bands (OCB) was blindly examined in paired cerebrospinal fluid (CSF) serum samples large PPMS patient cohort, related to imaging evidence focal inflammatory disease activity. Results Using cross‐sectional serial sampling subgroup...
The COVID-19 pandemic has resulted in 198 million reported infections and more than 4 deaths as of July 2021 (covid19.who.int). Research to identify effective therapies for includes: (1) designing a vaccine future protection; (2) de novo drug discovery; (3) identifying existing drugs repurpose them immediate treatments. To assist repurposing design, we determine two apo structures severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease at ambient temperature by serial...
Small molecule inhibitors have previously been investigated in different studies as possible therapeutics the treatment of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In current drug repurposing study, we identified leukotriene (D4) receptor antagonist montelukast a novel agent that simultaneously targets two important SARS-CoV-2. We initially demonstrated dual inhibition profile through multiscale molecular modeling studies. Next, characterized its effect on both by vitro...
Background: The complex pathogenesis of multiple sclerosis, combined with an unpredictable prognosis, requires identification disease-specific diagnostic and prognostic biomarkers. Objective: To determine whether inflammatory proteins, such as neurofilament light chain, myelin oligodendrocyte glycoprotein basic protein, neurodegenerative tau glial fibrillary acidic can serve biomarkers for predicting the clinical subtype prognosis MS. Methods: Cerebrospinal fluid serum samples were collected...
Antiapoptotic members of BCL-2 family proteins are one the overexpressed in cancer cells that oncogenic targets raise hopes for new therapeutic discoveries. Here, we have used multi-step screening and filtering approaches combine structure ligand-based drug design to identify new, effective inhibitors from small molecules database Specs SC. Compounds first filtered based on binary "cancer-QSAR" model common 26 toxicity QSAR models. Non-toxic compounds considered target-driven studies here...
Glycopolymers are synthetic macromolecules having pendant sugar moieties and widely utilized to target cancer cells. They usually considered as a hydrophilic segment of amphiphilic block copolymers fabricate micelles drug carriers. A novel copolymer, namely, poly(2-deoxy-2-methacrylamido-d-glucose-co-2-hydroxyethyl methacrylate)-b-poly(β-amino ester) [P(MAG-co-HEMA)-b-PBAE], with active cell targeting potential pH responsivity was prepared. Tetrazine end functional P(MAG-co-HEMA) norbornene...
Abstract Hedgehog signaling mediates embryologic development of the central nervous system and other tissues is frequently hijacked by neoplasia to facilitate uncontrolled cellular proliferation. Meningiomas, most common primary brain tumor, exhibit activation in 6.5% cases, triggered recurrent mutations pathway mediators such as SMO . In this study, we find 35.6% meningiomas that lack previously known drivers acquired various types somatic structural variations affecting chromosomes 2q35...
Introduction: Intracranial aneurysms (IAs) are abnormal dilations of brain arteries that can result in high mortality and morbidity when they rupture. Our study provides a spatial characterization 11 human IA tissues by utilizing transcriptomics proteomics with 6,000 RNA 64 protein markers, serving as comprehensive atlas the microenvironment. Methodology: Nanostring CosMX platform was used to spatially characterize proteomic transcriptomic profile IA- parental vessel wall fresh-frozen or...
Anti-apoptotic members of the Bcl-2 family proteins play central roles in regulation cell death glioblastoma (GBM), most malignant type brain tumor. Despite advances GBM treatment, there is still an urgent need for new therapeutic approaches. Here, we report a novel 4-thiazolidinone derivative BH3 mimetic, BAU-243 that binds to with high affinity. effectively reduced overall proliferation including subpopulation cancer-initiating cells contrast selective inhibitor ABT-199. While ABT-199...
Multiple sclerosis (MS) is an immune-mediated, neuro-inflammatory, demyelinating and neurodegenerative disease of the central nervous system (CNS) with a heterogeneous clinical presentation course. There remarkable phenotypic heterogeneity in MS, molecular mechanisms underlying it remain unknown. We aimed to investigate further etiopathogenesis related pathways subclinical types MS using proteomic bioinformatics approaches cerebrospinal fluids patients clinically isolated syndrome, relapsing...
Abstract Introduction Numerous efforts in natural product drug development are reported for the treatment of Coronavirus. Based on literature, among these plants Artemisia annua L . shows some promise SARS‐CoV‐2. Objective The main objective our study was to determine artemisinin content by liquid chromatography electrospray ionisation tandem mass spectrometry (LC‐ESI‐MS/MS), investigate vitro biological activity from A. grown Turkey with various extracted methods, elaborate silico against...
Background Predicting the long-term disability outcomes of multiple sclerosis (MS) cases is challenging. Objective We prospectively analysed our previous MS cohort with initial cerebrospinal fluid (CSF) proteomics data to reveal markers after 8.2±2.2 years follow-up. Methods Patients regular follow-up visits were assigned into two groups: those an age-related severity (ARMSS) score ≥5 (unfavourable course group, N = 27) and ARMSS <5 (favourable 67). A machine learning-based algorithm was...
Chiari malformation type I (CMI) is a brain that characterized by herniation of the cerebellum into spinal canal. highly heterogeneous; therefore, an accurate explanation pathogenesis disease often not possible. Although some studies showed role genetics in CMI, involvement genetic variations CMI has been thoroughly elucidated. Therefore, current study we aim to reveal CMI-associated genomic familial cases.Four patients and 7 unaffected healthy members two distinct families were analyzed. A...
Abstract In the current study, we used 7922 FDA approved small molecule drugs as well compounds in clinical investigation from NIH's NPC database our drug repurposing study. SARS‐CoV‐2 main protease Spike protein/ACE2 targets were virtual screening and top‐100 each docking simulations considered initially short molecular dynamics (MD) their average binding energies calculated by MM/GBSA method. Promising hit selected based on scores then long MD simulations. Based these numerical...
Isolated compounds 1 and 2 from Caulerpa cyclindracea inhibit the SARS-CoV-2 spike protein. Modelling studies suggest that may interfere with spike-ACE2 interaction directly also via an a allosteric site.
Object Angiogenesis and the platelet-derived growth factor (PDGF) pathway are active in pathogenesis of vestibular schwannomas (VSs). The purpose this study was to test whether imatinib mesylate (Gleevec), a PDGF receptor (PDGFR) blocker, reduces angiogenic capacity sporadic VS associated with neurofibromatosis Type 2 (NF2) using corneal angiogenesis assay. Methods From 121 tissue samples stored tumor bank at Marmara University Institute Neurological Sciences, 10 (6 from cases, 4...
B-Cell lymphoma 2 (BCL-2) regulates cell death in humans. In this study, combined multiscale silico approaches and vitro studies were employed. A small-molecule library that includes more than 210 000 compounds was used. The predicted therapeutic activity value (TAV) of the computed with binary cancer quantitative structure-activity relationships (QSAR) model. molecules a high calculated TAV used 26 individual toxicity QSAR models. As result screening protocol, 288 nontoxic identified. These...
The ubiquitin-specific protease 7 (USP7) is a highly promising well-validated target for variety of malignancies. USP7 critical in regulating the tumor suppressor p53 along with numerous epigenetic modifiers and transcription factors. Previous studies showed that inhibitors led to increased levels anti-proliferative effects hematological solid cell lines. Thus, this study aimed identify potent safe hit as potential anti-cancer therapeutics via an integrated computational approach combines...