Rogier Hintzen
A5081607909- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Cytokine Signaling Pathways and Interactions
- T-cell and B-cell Immunology
- Polyomavirus and related diseases
- Viral Infections and Immunology Research
- RNA regulation and disease
- Species Distribution and Climate Change
- vaccines and immunoinformatics approaches
- Ecology and Vegetation Dynamics Studies
- Immunotherapy and Immune Responses
- Neurogenesis and neuroplasticity mechanisms
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Protein Tyrosine Phosphatases
- Animal Ecology and Behavior Studies
- Skin and Cellular Biology Research
- Glycosylation and Glycoproteins Research
- Acute Lymphoblastic Leukemia research
- Atherosclerosis and Cardiovascular Diseases
- RNA Research and Splicing
- Sphingolipid Metabolism and Signaling
- Systemic Lupus Erythematosus Research
- Genetic Associations and Epidemiology
- interferon and immune responses
Imperial College London
2014-2025
Erasmus University Rotterdam
2010-2024
Erasmus MC
2010-2024
BenevolentAI (United Kingdom)
2023
John Wiley & Sons (United States)
2020
Hudson Institute
2020
Birmingham Children's Hospital
2019
Witten/Herdecke University
2019
Garrahan Hospital
2019
Massachusetts General Hospital
2019
Background: There has been tremendous growth in research pediatric multiple sclerosis (MS) and immune mediated central nervous system demyelinating disorders since operational definitions for these conditions were first proposed 2007. Further, the International Pediatric Multiple Sclerosis Study Group (IPMSSG), which criteria, expanded substantially membership its international scope. Objective: The purpose of this review is to revise 2007 order incorporate advances delineating clinical...
<h3>Importance</h3> Myelin oligodendrocyte glycoprotein antibodies (MOG-Abs) are consistently identified in a range of demyelinating disorders adults and children. Current therapeutic strategies largely center specific, no treatments have been formally evaluated. <h3>Objective</h3> To examine the clinical phenotypes, treatment responses, outcomes children with relapsing MOG-Ab–associated disease. <h3>Design, Setting, Participants</h3> This study prospectively collected demographic, clinical,...
Background and objective: We explored which clinical biochemical variables predict conversion from clinically isolated syndrome (CIS) to definite multiple sclerosis (CDMS) in a large international cohort. Methods: Thirty-three centres provided serum samples 1047 CIS cases with at least two years’ follow-up. Age, sex, presentation, T2-hyperintense lesions, cerebrospinal fluid (CSF) oligoclonal bands (OCBs), CSF IgG index, cell count, 25-hydroxyvitamin D3 (25-OH-D), cotinine titres against...
<h3>Objective</h3> Antibodies to cell surface central nervous system proteins help diagnose conditions which often respond immunotherapies. The assessment of antibody assays needs reflect their clinical utility. We report the results a multicentre study aquaporin (AQP) 4 (AQP4-Ab) in neuromyelitis optica spectrum disorders (NMOSD). <h3>Methods</h3> Coded samples from patients with (NMO) or NMOSD (101) and controls (92) were tested at 15 European diagnostic centres using 21 including live...
Chitinase 3-like 1 (CHI3L1) has been proposed as a biomarker associated with the conversion to clinically definite multiple sclerosis in patients isolated syndromes, based on finding of increased cerebrospinal fluid CHI3L1 levels syndrome who later converted compared those remained syndrome. Here, we aimed validate prognostic large cohort This is longitudinal study clinical, magnetic resonance imaging, and data prospectively acquired. A total 813 samples from were recruited 15 European...
The choice of appropriate control group(s) is critical in cerebrospinal fluid (CSF) biomarker research multiple sclerosis (MS). There a lack definitions and nomenclature different groups rationalized application groups. We here propose consensus for the following groups: healthy controls (HCs), spinal anesthesia subjects (SASs), inflammatory neurological disease (INDCs), peripheral (PINDCs), non-inflammatory (NINDCs), symptomatic (SCs). Furthermore, we discuss these specific study designs,...
Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. strands evidence suggest that much the remaining also due additive effects variants rather than epistasis between these or mutations exclusive individual families. Here, we show in 68,379 cases and controls up 5% this explained low-frequency variation gene coding sequence. We identify four novel genes...
Remotely sensed data - available at medium to high resolution across global spatial and temporal scales are a valuable resource for ecologists. In particular, products from NASA's MODerate-resolution Imaging Spectroradiometer (MODIS), providing twice-daily coverage, have been widely used ecological applications. We present MODISTools, an R package designed improve the accessing, downloading, processing of remotely MODIS data. MODISTools automates process downloading any number locations,...
About 3—5% of all patients with multiple sclerosis experience the onset their disease under age 16. A significant proportion paediatric develop cognitive disturbances and persistent physical disability. The high relapse rate morbidity in population has triggered use disease-modifying therapies that have been shown to reduce rate, progression decline adult sclerosis. Hard evidence for right treatment its appropriate timing is scarce Nevertheless, expertise this field grown thanks recent...
<h3>Objective</h3> The impetus for this consensus discussion was to recommend clinical trial designs that can deliver high-quality data effective therapies pediatric patients, in a reasonable timeframe, with key focus on short- and long-term safety. <h3>Methods</h3> International Pediatric Multiple Sclerosis Study Group convened meeting of experts review the advances understanding pediatric-onset multiple sclerosis (MS) advent trials population. <h3>Results</h3> In last few years, convincing...
A recent genome-wide association study reported five loci for which there was strong, but sub-genome-wide significant evidence with multiple sclerosis risk. The aim of this to evaluate the role these potential risk in a large and independent data set ≈ 20,000 subjects. We tested single nucleotide polymorphisms rs228614 (MANBA), rs630923 (CXCR5), rs2744148 (SOX8), rs180515 (RPS6KB1), rs6062314 (ZBTB46) total 8499 cases sclerosis, 8765 unrelated control subjects 958 trios European descent. In...
Conservation biology was founded on the idea that efforts to save nature depend a scientific understanding of how it works. It sought apply ecological principles conservation problems. We investigated whether relationship between these fields has changed over time through machine reading full texts 32,000 research articles published in 16 ecology and journals. examined changes topics both have evolved from 2000 2014. As matured, its focus shifted social political aspects conservation. The 2...
Abstract Objective Chronic neurotoxicity is a recognized long‐term complication following chemotherapy in range of diseases. Neurotoxicity adversely affects patients' quality life. The objective this study to examine whether there evidence acute neurotoxicity. Methods This prospective included patients with secondary progressive multiple sclerosis (SPMS‐BMT, n = 14) and hematological malignancies (HM‐BMT, 17) receiving as preconditioning for bone marrow transplant. control groups SPMS...
Socially learned signals and behaviors are found throughout the animal kingdom often show striking variation within species over space time. However, extent to which this cultural diversity is generated by demographic factors such as immigration dispersal has proved difficult investigate remains largely untested in a natural setting. Focusing on 14 different local neighborhoods wild population of great tits Parus major, we examined relationship between individual movements 7-year period...
<h3>Objective</h3> A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform reported on 11 loci that showed suggestive genetic association with MS. Additional data sufficiently sized and independent sets are needed to assess whether these represent genuine MS risk factors. <h3>Methods</h3> The lead SNPs of all were genotyped 10 796 cases 793 controls from Germany, Spain, France, Netherlands, Austria Russia, previously cohorts. Association analyses performed...