A5006770691- Multiple Sclerosis Research Studies
- Systemic Sclerosis and Related Diseases
- Cytokine Signaling Pathways and Interactions
- Polyomavirus and related diseases
- Peripheral Neuropathies and Disorders
- Long-Term Effects of COVID-19
- Human Health and Disease
- Monoclonal and Polyclonal Antibodies Research
- RNA regulation and disease
- MicroRNA in disease regulation
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Medical and Biological Sciences
- Thyroid Disorders and Treatments
- Reproductive System and Pregnancy
- Viral Infections and Immunology Research
- Memory and Neural Mechanisms
- BRCA gene mutations in cancer
- Biosimilars and Bioanalytical Methods
- Medicinal Plants and Bioactive Compounds
- Toxin Mechanisms and Immunotoxins
- Neurological Disorders and Treatments
- Epigenetics and DNA Methylation
City Clinical Hospital No. 2
2015-2024
Pirogov Russian National Research Medical University
2015-2024
Uzbek State University of World Languages
2024
Republican Oncological Clinical Dispensary
2022-2023
Ministry of Health of the Russian Federation
2015-2023
City Clinical Hospital
2014-2023
Moscow Power Engineering Institute
2023
Moscow Aviation Institute
2023
All-Russian Scientific Research Institute of Experimental Veterinary Sciences. Ya.R. Kovalenko
2016-2020
Ludovika University of Public Service
2020
Multiple sclerosis (MS) is a severe neurodegenerative disease of polygenic etiology affecting the central nervous system. In addition to genetic factors, epigenetic mechanisms, primarily DNA methylation, which regulate gene expression, play an important role in MS development and progression. this study, we have performed first whole-genome methylation profiling peripheral blood mononuclear cells relapsing-remitting (RRMS) primary-progressive (PPMS) patients compared them those healthy...
BackgroundIn the phase III OlympiAD trial, olaparib significantly increased progression-free survival (PFS) compared with chemotherapy of physician's choice in patients germline BRCA-mutated (gBRCAm), human epidermal growth factor 2 (HER2)-negative metastatic breast cancer (mBC). The IIIb LUCY trial assessed clinical effectiveness similar patients, a setting reflecting practice.MethodsThis open-label, single-arm (300 mg, twice daily) enrolled BRCAm, HER2-negative mBC who had received taxane...
<h3>Objective</h3> A recent large-scale study in multiple sclerosis (MS) using the ImmunoChip platform reported on 11 loci that showed suggestive genetic association with MS. Additional data sufficiently sized and independent sets are needed to assess whether these represent genuine MS risk factors. <h3>Methods</h3> The lead SNPs of all were genotyped 10 796 cases 793 controls from Germany, Spain, France, Netherlands, Austria Russia, previously cohorts. Association analyses performed...
Multiple sclerosis (MS) is an autoimmune neuro-inflammatory disease arising from complex interactions of genetic, epigenetic, and environmental factors. Variations in genes some microRNAs--key post-transcriptional regulators many genes--can influence microRNAs expression/function contribute to MS via expression changes protein-coding target mRNA genes. We performed association study polymorphous variants MIR146A rs2910164, MIR196A2 rs11614913, MIR499A rs3746444 MIR223 rs1044165 their...
The gut microbiota functions as an independent organ, influencing bodily systems and disease development, though its role in multiple sclerosis (MS) pathogenesis remains unclear. This study evaluated composition young individuals with relapsing-remitting MS (РРС) onset compared to healthyusing Statsoft Statistica 12, involved normality tests (Kolmogorov-Smirnov, Shapiro-Wilk), Mann-Whitney U (p≤0.05). Results showed РРС patients had a significant predominance of Clostridium difficile...
Multiple sclerosis (MS) is a serious, incurable neurological disease. In 2009, the ANZgene studies detected suggestive association of located upstream CD40 gene in chromosome 20q13 (p = 1.3×10−7). Identification causal variant(s) locus leads to better understanding mechanism underlying development autoimmune pathologies. We determined genotypes rs6074022, rs1883832, rs1535045, and rs11086996 patients with MS (n 1684) control group 879). Two SNPs were significantly associated MS: rs6074022...
Pregnancy rates are rapidly increasing among women of reproductive age diagnosed with multiple sclerosis (MS). Over the past decades, several studies have proven that MS does not affect course pregnancy, and pregnancy negatively long-term disease. The results numerous shown frequency exacerbations in patients decreases during but increases after childbirth. According to summary product characteristics (SmPC) disease modifying drugs (DMD) most them contraindicated pregnancy. To prevent...
In order to assess the value of management strategies in multiple sclerosis (MS), outcome data have be combined with cost data. This, turn, requires that regularly updated.This study is part a cross-sectional retrospective 16 countries collecting current on resource consumption, work capacity and health-related quality life (HQoL). Descriptive analyses are presented by level severity; costs estimated societal perspective, RUB 2015.A total 208 patients (mean age: 38.5 years) participated...
Relapsing-remitting multiple sclerosis (RRMS) is the most prevalent course of sclerosis. It an autoimmune inflammatory disease central nervous system. To investigate gender-specific involvement microRNAs (miRNAs) in RRMS pathogenesis, we compared miRNA profiles peripheral blood mononuclear cells separately men and women (eight patients versus four healthy controls each gender) using high-throughput sequencing. In contrast to women, six downregulated 26 upregulated miRNAs (padj < 0.05)...
In this article, the authors compared results of studies on quality life (SF-36 questionnaire) large groups patients with multiple sclerosis conducted in 2000-2003 and 2012-2016 years.В статье представлены результаты сравнительного анализа показателей качества жизни больных с рассеянным склерозом, проведенного использованием опросника SF-36 в нескольких популяциях разные временны`е интервалы (в и гг.).
To study the efficacy and tolerability of generics (interferon beta-1a biosimilans) cinnovex for intramascular introduction genfaxon-44 subcutaneous injections in multiple sclerosis (MS).One hundred patients were treated with 104 during one year. Patient's status was assessed using clinical approach, psychometric scales MRI.The high percentage withdrawal treatment due to lack effect intolerance drugs identified treatment. Positive respect stabilization MS course found only who earlier did...
NTZ is approved in Russia for the treatment of highly active relapsing remitting multiple sclerosis and reimbursed via federal budget program. However, no data about effect reimbursement have been performed so far.
The main results of a medical-sociological study aimed at the evaluation level satisfaction with treatment in patients primary progressive multiple sclerosis (PPMS) are presented. survey was conducted 19 regions Russian Federation and involved 437 confirmed diagnosis PPMS 80 neurologists specialized sclerosis. research carried out by All-Russian Public Organization Disabled People Multiple Sclerosis participation Committee for Treatment Research Sclerosis. This is first involving...
To evaluate efficacy and safety of biosimilars interferon beta-1b (Infibeta) in patients aged 14 to 17 years.Interferon beta 1b was appointed 9 children adolescents (4 boys 5 girls) between the ages years (mean age onset therapy 16.22±1.09).In course there a significant decrease annualrelapse rate (ARR) 0.33±0.5 (from 0 1, r≤0,0001) regression neurological deficit on EDSS scale up ±1.94±0.68 (1.5 3, p≤0.05). No cases cancellation not recorded due poor tolerability or inefficiency.Although...
The paper presents a detailed algorithm for the treatment and follow-up of patients with recurrent multiple sclerosis primary progressive in use ocrelizumab.
Diagnosis of secondary progressive multiple sclerosis (SPMS) is based on a history gradual worsening neurological symptoms within 6-12 months without exacerbations following an initial relapsing-remitting (RRMS) disease course. In the absence reliable MRI, immunological and clinical markers, it hardly possible to achieve objectivity in determining transition MS stage. This often leads long period diagnostic uncertainty, which prevents timely therapeutic decisions. Physicians expressed unmet...
At the present time, disease modifying drugs (DMD) for treatment of patients with multiple sclerosis are used to reduce risk exacerbations and, consequently, slowing progression disability in accordance standards. However, application first line this therapy is not always successful. In these situations, receive second-line DMD. Fingolimod one Russia. To gain experience using fingolimod routine neurological practice, we have conducted a post-marketing research - GIMN. К настоящему времени в...
For a long time it was believed that pregnancy worsens the clinical course of multiple sclerosis. In several European countries, there have been studies demonstrated remission autoimmune aggression during pregnancy. We studied effect on sclerosi.A retrospective analysis disease 279 patients performed for first in three major Russian centers (Moscow, Novosibirsk, Tyumen).There The use DMT before predictor more favorable after delivery. An earlier beginning delivery led to significant risk...