A5091450420- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Meningioma and schwannoma management
- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Tissue Engineering and Regenerative Medicine
- Orthopedic Surgery and Rehabilitation
- Neurofibromatosis and Schwannoma Cases
- Metal Alloys Wear and Properties
- Bone Tumor Diagnosis and Treatments
- Head and Neck Surgical Oncology
- Adrenal and Paraganglionic Tumors
- Anatomy and Medical Technology
Massachusetts General Hospital
2025
Cleveland Shoulder Institute
2025
University of Chicago
2021-2023
Yale University
2019
OBJECTIVE Recent large-cohort sequencing studies have investigated the genomic landscape of meningiomas, identifying somatic coding alterations in NF2 , SMARCB1 SMARCE1 TRAF7, KLF4, POLR2A BAP1 and members PI3K Hedgehog signaling pathways. Initial associations between clinical features subgroups been described, including location, grade, histology. However, further investigation using an expanded collection samples is needed to confirm previous findings, as well elucidate relationships not...
Abstract BACKGROUND Previous studies have established several meningioma genomic subgroups, defined by the mutually exclusive drivers. However, we distinguished a small subset of meningiomas simultaneously harboring multiple drivers from different thus referred to as “multiple-driver meningiomas”, that has not been previously investigated. We aimed characterize landscape and clinical features multiple-driver meningiomas. METHODS identified 42 cases cohort 3,016 screened for via molecular...
Abstract Cardiac tissue engineering has been developed as a potential alternative treatment for heart failure. However, current 3D tissues are limited in size and thickness due to the lack of an effective vascularization method. We have novel bioreactor system create viable vascularized cardiac from multicellular spheroids using digital light processing (DLP) bioprinting system. Spheroids were created induced pluripotent stem cells (iPSC) fibroblasts (FB) special dimple plates mass...
Background: Cardiac tissue engineering has beendeveloped as apotential alternativetreatment for heart failure. However, current 3D tissues are limited insize and thickness due tothe lack of aneffective vascularizationmethod. We have developed anovel bioreactor systemtocreate viable vascularized cardiac from multicellular spheroids using adigital lightprocessing (DLP)3D bioprinting system. Methods: Spheroids were created induced pluripotent stem cells (iPSC)and cardiacfibroblasts (FB)using...