A5073284936- Meningioma and schwannoma management
- Glioma Diagnosis and Treatment
- Neurofibromatosis and Schwannoma Cases
- Pituitary Gland Disorders and Treatments
- Management of metastatic bone disease
- Head and Neck Surgical Oncology
- Brain Metastases and Treatment
- Spinal Fractures and Fixation Techniques
- Advanced Radiotherapy Techniques
- Nanoplatforms for cancer theranostics
- Facial Nerve Paralysis Treatment and Research
- Bone and Joint Diseases
- Ocular Oncology and Treatments
- Vascular Malformations Diagnosis and Treatment
- Corneal Surgery and Treatments
- Surgical Simulation and Training
- Spinal Dysraphism and Malformations
- Neuroscience and Neural Engineering
- Antifungal resistance and susceptibility
- Hip and Femur Fractures
- Medical and Biological Sciences
- Orbital Angular Momentum in Optics
- Scoliosis diagnosis and treatment
- Cancer Diagnosis and Treatment
- Craniofacial Disorders and Treatments
Witten/Herdecke University
2022-2025
Queen Square Radiosurgery Centre
2024-2025
Evangelisches Krankenhaus Hamm
2021-2024
Charité - Universitätsmedizin Berlin
2024
Ludwig-Maximilians-Universität München
2024
Center for Neuro-Oncology
2024
German Cancer Research Center
2024
University of Cologne
2024
Humboldt-Universität zu Berlin
2024
Heidelberg University
2024
Radiosurgery is the main alternative to microsurgical resection for benign meningiomas.To assess long-term efficacy and safety of radiosurgery meningiomas with respect tumor growth prevention associated neurological deterioration. Medium- outcomes have been widely reported, but no large multicenter series follow-up published.From 15 participating centers, we performed a retrospective observational analysis 4565 consecutive patients harboring 5300 meningiomas. All were treated Gamma Knife at...
There is a critical need for objective and reliable biomarkers of outcome in meningiomas beyond WHO classification. Loss H3K27me3 has been reported as prognostically unfavorable alteration meningiomas. We sought to independently evaluate the reproducibility prognostic value loss by immunohistochemistry (IHC) multicenter study.IHC staining analyses whole slides from 181 across three centers was performed. Staining analyzed dichotomization into retained immunoreactivity, using 3-tiered scoring...
Stereotactic radiosurgery with established systems like the Gamma Knife and CyberKnife (Accuray Inc., Madison, WI, USA) is a well-characterized treatment concept. The novel ZAP-X® platform (ZAP Surgical Systems San Carlos, CA, for vault-free, self-shielding gyroscopic (GRS) promises high plan quality due to advantageous beam properties. However, clinically usable workspace in GRS reduced potential collisions spacious headrest. A "conformal" headrest was introduced December 2023 remedy this,...
Cerebral metastases are the most frequent cerebral tumours. Surgery of plays an indispensible role in a multimodal therapy concept. Conventional white-light, microscopy assisted microsurgical and circumferential stripping is neurosurgical standard therapy, but associated with extraordinarily high recurrence rate more than 50% without subsequent whole-brain radiotherapy. Therefore, fails to achieve local tumour control many patients. The present conceptual paper focuses on this issue...
Background Stereotactic radiosurgery is a well-established treatment option for the management of various benign and malignant brain tumors. It can be delivered with several platforms, usually requiring shielded radiation vaults to meet regulatory safety requirements. Recent technical advances have led first self-shielding platform enabling delivery gyroscopic (GRS). Given limited number GRS novelty its characteristics, lack available data, we report our prospective experience 100 patients...
Pituitary adenomas (PA), especially invasive ones, are often not completely resectable. Usage of 5-aminolevulinic acid (5-ALA) for fluorescence guided surgery could improve the rate total resection and, additionally, open doors photodynamic therapy (PDT) in case unresectable or partially resected PAs. The aim this study was to investigate uptake 5-ALA and effect based PDT cell lines.GH3 AtT-20 lines were incubated with different concentrations 5-ALA, protoporphyrin IX (PPIX) measured by flow...
Abstract Background and Study Aims Spinal fusion for symptomatic lumbar spondylolisthesis can be accomplished using an open or minimally invasive surgical (MIS) technique. Evaluation of segmental instabilities review their therapies are inseparably connected with tomographic imaging. We analyzed a cohort patients who underwent MIS monosegmental dorsal compared outcomes along complication rates. furthermore evaluated the influence virtual reality (VR) visualization on planning in fusion....
Cavernous sinus meningiomas (CSMs) remain a surgical challenge due to the intimate involvement of their contained nerves and blood vessels. Stereotactic radiosurgery (SRS) is safe effective minimally invasive alternative for treatment small- medium-sized CSMs. Objective: To assess medium- long-term outcomes SRS CSMs with respect tumour growth, prevention further neurological deterioration improvement existing deficits. This multicentric study included data from 15 European institutions. We...
The field of neurosurgery faces challenges with the increasing involvement other medical specialties in areas traditionally led by neurosurgeons. This paper examines implications this development for neurosurgical practice and patient care, a focus on specialized like pain management, peripheral nerve surgery, stereotactic radiosurgery. To assess expanded scope to consider response EANS Frontiers Neurosurgery Committee these challenges. Analysis recent trends neurosurgery, including shift...
Stereotactic radiosurgery (SRS) is a well-established treatment modality for the management of uveal melanoma, achieving high tumor control and eye retention rates. There are several SRS platforms available, including recently developed self-shielding gyroscopic (GRS) system. We report first use GRS in melanoma. 63-year-old female patient with left-sided Akinesia ocular globe orbit was achieved by retrobulbar anesthesia. The plan used six isocenters (three 10 mm three 7.5 apertures) 140...
Background: Adequate and stable coverage of cranial contour continuity defects any origin is a common challenge in neurosurgical clinics. This study presents the results investigations concerning mechanical load-bearing capacity design advantages custom-made implants made from thin, pure-titanium sheet (CranioTop) (CLinstruments, Attendorn, Germany) for covering complex defects. Methods: In 9 test series, stability three differently shaped sized thin titanium was tested using vertical,...
Key Clinical Message Sporadic Medullary Carcinoma of the Thyroid is a relatively uncommon entity and at time diagnosis, most already present loco‐regional metastasis. Therapy should be aggressive to reduce recurrence mortality. Follow‐up period continue lifelong also include calcium/pentagastrin infusion test, as well 6‐month interval diagnostic imaging.
(1) Background: Infections in deep brain stimulation (DBS) hardware, while an undesired complication of DBS surgeries, can be effectively addressed. Minor infections are typically treated with wound revision and IV antibiotics. However, when visible hardware infection occurs, most centers opt for complete removal, leaving the patient a preoperative state necessitating post-removal care. To avoid need such care, novel technique was developed. (2) Methods: The electrodes placed at exact same...
We report the case of a patient approximately five years after therapy for lung carcinoma with surgery, radio- and chemotherapy who complained about increasing back pain in cervico-thoracic spine.
Abstract BACKGROUND This study evaluates the outcomes of WHO grade II meningiomas treated with stereotactic radiosurgery (SRS) using a large, multi-institutional European database. We aim to investigate long-term tumor control rate and morbidity associated SRS. METHODS Data from 355 consecutive patients between 1992 2022 at 16 centers were retrospectively analyzed. After excluding 40 due loss follow-up, results 315 included. Clinical imaging data independently collected by each center...