A5036454720- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Cardiac Arrest and Resuscitation
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- S100 Proteins and Annexins
- Cerebrospinal fluid and hydrocephalus
- Intracerebral and Subarachnoid Hemorrhage Research
- Advanced Neuroimaging Techniques and Applications
- Trauma and Emergency Care Studies
- Mitochondrial Function and Pathology
- Neuroinflammation and Neurodegeneration Mechanisms
- Bioinformatics and Genomic Networks
- Genetic Associations and Epidemiology
- Neurological disorders and treatments
- Genetic Neurodegenerative Diseases
- Spinal Cord Injury Research
- Neurological Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Neuroscience and Neuropharmacology Research
- Neurological diseases and metabolism
- Neurogenetic and Muscular Disorders Research
- Neurological Disorders and Treatments
Boston University
2016-2025
VA Boston Healthcare System
2016-2025
VA New England Healthcare System
2013-2025
Edith Nourse Rogers Memorial Veterans Hospital
2008-2025
Alzheimer’s Disease Neuroimaging Initiative
2014-2025
United States Department of Veterans Affairs
2000-2024
Framingham Heart Study
2012-2024
National Center for PTSD
2022-2024
University of Rwanda
2024
Sahlgrenska University Hospital
2024
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as consequence of repetitive mild brain injury.We analysed post-mortem brains obtained from cohort 85 subjects with histories injury and found evidence chronic in 68 subjects: all males, ranging age 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% whom were also athletes) one individual who engaged self-injurious head banging behaviour.Eighteen age-and gender-matched individuals without...
Automated analysis of MRI data the subregions hippocampus requires computational atlases built at a higher resolution than those that are typically used in current neuroimaging studies. Here we describe construction statistical atlas hippocampal formation subregion level using ultra-high resolution, ex vivo MRI. Fifteen autopsy samples were scanned 0.13 mm isotropic (on average) customized hardware. The images manually segmented into 13 different substructures protocol specifically designed...
<h3>Importance</h3> Players of American football may be at increased risk long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). <h3>Objective</h3> To determine the neuropathological and clinical features deceased players with CTE. <h3>Design, Setting, Participants</h3> Case series 202 whose brains were donated for research. Neuropathological evaluations retrospective telephone assessments (including head trauma history) informants performed blinded. Online...
Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans experimental animals.
Recent demonstrations that the secretion, uptake, and interneuronal transfer of tau can be modulated by disease-associated modifications suggest secretion may an important element in tau-induced neurodegeneration. Here, we show much secreted M1C cells occurs via exosomal release, a widely characterized mechanism mediates unconventional other aggregation-prone proteins (α-synuclein, prion protein, β-amyloid) neurodegenerative disease. Exosome-associated is also present human CSF samples...
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed post-mortem examination brain tissue. As first part series consensus panels funded NINDS/NIBIB to define neuropathological criteria for CTE, preliminary were used 7 neuropathologists blindly evaluate 25 cases various tauopathies, including...
Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is increased in association with head injury. Repetitive injury also associated development chronic traumatic encephalopathy (CTE), a tauopathy characterized by neurofibrillary tangles throughout brain relative absence β-amyloid deposits. We examined 12 cases CTE and, 10, found widespread TAR DNA-binding protein approximately 43kd (TDP-43) proteinopathy affecting frontal and temporal cortices, medial lobe,...
Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly the nucleus, but affected areas ALS FTLD-U central nervous system, aberrantly processed forms cytoplasmic inclusions. The mechanisms governing inclusion formation are poorly understood. Increasing evidence indicates that regulates mRNA metabolism by interacting with binding proteins known to...
The goal of this study was to examine the clinical presentation chronic traumatic encephalopathy (CTE) in neuropathologically confirmed cases.Thirty-six adult male subjects were selected from all cases CTE at Boston University Center for Study Traumatic Encephalopathy brain bank. Subjects athletes, had no comorbid neurodegenerative or motor neuron disease, and next-of-kin informants provide retrospective reports subjects' histories presentations. These interviews conducted blind...
The term “repetitive head impacts” (RHI) refers to the cumulative exposure concussive and subconcussive events. Although RHI are believed increase risk for later-life neurological consequences (including chronic traumatic encephalopathy), quantitative analysis of this relationship has not yet been examined because lack validated tools quantify lifetime exposure. objectives study were: 1) develop a metric from football, which we “cumulative impact index” (CHII); 2) use CHII examine...