A5033938075- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Spinal Cord Injury Research
- Cerebrospinal fluid and hydrocephalus
- Cerebral Palsy and Movement Disorders
- Trauma and Emergency Care Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Amyotrophic Lateral Sclerosis Research
- Injury Epidemiology and Prevention
- S100 Proteins and Annexins
- Neurogenetic and Muscular Disorders Research
- Cardiovascular Effects of Exercise
- Advanced Neuroimaging Techniques and Applications
- Sports injuries and prevention
- Advanced MRI Techniques and Applications
- Child Abuse and Related Trauma
- Mitochondrial Function and Pathology
- Stroke Rehabilitation and Recovery
- Traumatic Ocular and Foreign Body Injuries
- Automotive and Human Injury Biomechanics
- Organ Donation and Transplantation
- Psychosomatic Disorders and Their Treatments
Boston University
2016-2025
Emerson Hospital
2010-2021
Framingham Heart Study
2021
Sports Concussion Institute
2018
VA Boston Healthcare System
2013-2016
Legacy International
2010-2014
National Center for Post Traumatic Stress Disorder
2014
Geriatric Research Education and Clinical Center
2010
Icahn School of Medicine at Mount Sinai
2010
McLean Hospital
2010
Chronic traumatic encephalopathy is a progressive tauopathy that occurs as consequence of repetitive mild brain injury.We analysed post-mortem brains obtained from cohort 85 subjects with histories injury and found evidence chronic in 68 subjects: all males, ranging age 17 to 98 years (mean 59.5 years), including 64 athletes, 21 military veterans (86% whom were also athletes) one individual who engaged self-injurious head banging behaviour.Eighteen age-and gender-matched individuals without...
<h3>Importance</h3> Players of American football may be at increased risk long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE). <h3>Objective</h3> To determine the neuropathological and clinical features deceased players with CTE. <h3>Design, Setting, Participants</h3> Case series 202 whose brains were donated for research. Neuropathological evaluations retrospective telephone assessments (including head trauma history) informants performed blinded. Online...
Blast exposure is associated with chronic traumatic encephalopathy, impaired neuronal function, and persistent cognitive deficits in blast-exposed military veterans experimental animals.
Epidemiological evidence suggests that the incidence of amyotrophic lateral sclerosis is increased in association with head injury. Repetitive injury also associated development chronic traumatic encephalopathy (CTE), a tauopathy characterized by neurofibrillary tangles throughout brain relative absence β-amyloid deposits. We examined 12 cases CTE and, 10, found widespread TAR DNA-binding protein approximately 43kd (TDP-43) proteinopathy affecting frontal and temporal cortices, medial lobe,...
The goal of this study was to examine the clinical presentation chronic traumatic encephalopathy (CTE) in neuropathologically confirmed cases.Thirty-six adult male subjects were selected from all cases CTE at Boston University Center for Study Traumatic Encephalopathy brain bank. Subjects athletes, had no comorbid neurodegenerative or motor neuron disease, and next-of-kin informants provide retrospective reports subjects' histories presentations. These interviews conducted blind...
The term “repetitive head impacts” (RHI) refers to the cumulative exposure concussive and subconcussive events. Although RHI are believed increase risk for later-life neurological consequences (including chronic traumatic encephalopathy), quantitative analysis of this relationship has not yet been examined because lack validated tools quantify lifetime exposure. objectives study were: 1) develop a metric from football, which we “cumulative impact index” (CHII); 2) use CHII examine...
The mechanisms underpinning concussion, traumatic brain injury, and chronic encephalopathy, the relationships between these disorders, are poorly understood. We examined post-mortem brains from teenage athletes in acute-subacute period after mild closed-head impact injury found astrocytosis, myelinated axonopathy, microvascular perivascular neuroinflammation, phosphorylated tau protein pathology. To investigate causal mechanisms, we developed a mouse model of lateral that uses momentum...
Objective Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease associated with exposure to contact and collision sports, including American football. We hypothesized dose–response relationship between duration of football played CTE risk severity. Methods In convenience sample 266 deceased players from the Veterans Affairs–Boston University–Concussion Legacy Foundation Framingham Heart Study Brain Banks, we estimated association years pathological status evaluated ability...
Abstract Previous research suggests that age of first exposure (AFE) to football before 12 may have long-term clinical implications; however, this relationship has only been examined in small samples former professional players. We the association between AFE and behavior, mood cognition a large cohort amateur The sample included 214 players without other contact sport history. Participants completed Brief Test Adult Cognition by Telephone (BTACT), self-reported measures executive function...
Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts (RHI), but the components of RHI exposure underlying this relationship are unclear. We create position matrix (PEM), composed American football helmet sensor data, summarized from literature review by player and level play. Using PEM, we estimate measures lifetime for separate cohort 631 playing brain donors. Separate models examine between CTE pathology players' concussion count,...
Young contact sport athletes may be at risk for long-term neuropathologic disorders, including chronic traumatic encephalopathy (CTE).
<h3>Background/aim</h3> Despite concussion education being increasingly mandated by states and sports leagues, there has been limited evaluation of what is in fact effective. The National Collegiate Athletic Association (NCAA) currently mandates that institutions provide education, without specifying content or delivery. present study evaluated the effectiveness this general mandate, as enacted for male collegiate ice hockey teams within one conference competition. <h3>Methods</h3> In a...
Microglia, the resident immune cells of central nervous system, play an important role in brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single repeated traumatic brain injury, possibly through sports-related concussive subconcussive injuries. Limited vivo imaging studies months years individuals experience a moderate severe suggest widespread persistent activation, but there little study glial cell activity...
To examine the effect of age first exposure to tackle football on chronic traumatic encephalopathy (CTE) pathological severity and neurobehavioral symptom onset in players with neuropathologically confirmed CTE.The sample included 246 who donated their brains for neuropathological examination. Two hundred eleven were diagnosed CTE (126 211 without comorbid neurodegenerative diseases), 35 CTE. Informant interviews ascertained cognitive behavioral/mood onset.Analyses accounted decade duration...
Abstract Introduction Chronic traumatic encephalopathy (CTE) is a progressive neurodegeneration associated with repetitive head impacts. Understanding Neurologic Injury and Traumatic Encephalopathy (UNITE) U01 project recently funded by the National Institute of Neurological Disorders Stroke Biomedical Imaging Bioengineering. The goal UNITE to examine neuropathology clinical presentation brain donors designated as “at risk” for development CTE based on prior athletic or military exposure....
This study aimed to evaluate whether preseason concussion knowledge and reporting intention predicted in-season behavior.Prospective cohort study.Collegiate athletic facility of each participating team.National Collegiate Athletic Association Division I men's ice hockey players in 1 conference competition (n = 116).Intention report symptoms a "minor" were assessed at preseason.Postseason recall non-report postimpact symptoms.Preseason was not significantly associated with behavior. Intention...