A5007203242- Functional Brain Connectivity Studies
- Dementia and Cognitive Impairment Research
- Neurological disorders and treatments
- Alzheimer's disease research and treatments
- Treatment of Major Depression
- Advanced Neuroimaging Techniques and Applications
- Neurotransmitter Receptor Influence on Behavior
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Parkinson's Disease Mechanisms and Treatments
- Sleep and related disorders
- Nicotinic Acetylcholine Receptors Study
- Traumatic Brain Injury and Neurovascular Disturbances
- Memory and Neural Mechanisms
- Schizophrenia research and treatment
- Transcranial Magnetic Stimulation Studies
- Genetic Neurodegenerative Diseases
- Diet and metabolism studies
- Receptor Mechanisms and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Traumatic Brain Injury Research
- Health and Medical Research Impacts
- Radiomics and Machine Learning in Medical Imaging
Johns Hopkins Medicine
2016-2025
Johns Hopkins University
2016-2025
Mayo Clinic in Arizona
2025
Vanderbilt University Medical Center
2025
Mayo Clinic
2012-2023
University of California, Irvine
2023
Institute for Behavioral Medicine
2023
Society of Nuclear Medicine and Molecular Imaging
2021
Cornell University
2011-2019
Greater Manchester Mental Health NHS Foundation Trust
2018-2019
Abstract Objective Alzheimer disease (AD) is characterized by functional impairment in the neural elements and circuits underlying cognitive memory functions. We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity these pathological possibly produce clinical benefits. Methods conducted a phase I trial 6 patients with mild AD receiving ongoing medication treatment. Patients received continuous for 12 months. Three main lines of...
Abstract Magnetic resonance-guided focused ultrasound in combination with intravenously injected microbubbles has been shown to transiently open the blood–brain barrier, and reduce beta-amyloid tau pathology animal models of Alzheimer’s disease. Here, we used barrier five patients early moderate disease a phase I safety trial. In all patients, within target volume was safely, reversibly, repeatedly opened. Opening did not result serious clinical or radiographic adverse events, as well no...
Abstract Neuropsychiatric symptoms (NPS) are common in dementia and predementia syndromes such as mild cognitive impairment (MCI). NPS MCI confer a greater risk for conversion to comparison patients without NPS. older adults with normal cognition also confers of decline Mild behavioral (MBI) has been proposed diagnostic construct aimed identify an increased developing dementia, but who may or not have symptoms. We propose criteria that include the MBI framework, contrast prior definitions...
Background: Mild behavioral impairment (MBI) is a construct that describes the emergence at ≥50 years of age sustained and impactful neuropsychiatric symptoms (NPS), as precursor to cognitive decline dementia. MBI NPS any severity, which are not captured by traditional psychia tric nosology, persist for least 6 months, occur in advance or concert with mild impairment. While detection description has been operationalized International Society Advance Alzheimer's Research Treatment –...
Background: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional circuits.The safety and efficacy DBS in dementia unknown.Objective: To assess memory circuits as a treatment for patients with mild Alzheimer's disease (AD).Methods: We evaluated active "on" versus sham "off" bilateral directed at fornix-a major fiber bundle brain's circuit-in randomized, double-blind trial (ClinicalTrials.govNCT01608061) 42 AD.We measured cognitive function cerebral glucose metabolism...
Psilocybin has shown promise for the treatment of mood disorders, which are often accompanied by cognitive dysfunction including rigidity. Recent studies have proposed neuropsychoplastogenic effects as mechanisms underlying enduring therapeutic psilocybin. In an open-label study 24 patients with major depressive disorder, we tested psilocybin therapy on flexibility (perseverative errors a set-shifting task), neural (dynamics functional connectivity or dFC via magnetic resonance imaging), and...
Abstract Bilatera decreases in striatal 11 C‐raclopride binding were observed adult female baboons with high resolution PET following administration of drugs that act centrally on dopaminergic neurons. At baseline and d‐amphetamine (a dopamine‐releasing drug), GBR‐12909 potent dopamine reuptake inhibitor), or tetrabenazine biogenic amine depleting drug) scans obtained a CTI 931 positron tomograph. In all studies, the ratio distribution volumes for striatum to cerebellum decreased...
• Positron emission tomographic studies of cerebral glucose metabolism have shown high diagnostic specificity in distinguishing among the degenerative dementias and differentiating between Alzheimer's disease (AD) normal aging. The current investigation was undertaken to characterize regional metabolic deficits AD, using cross-sectional longitudinal study designs. All subjects met National Institute Neurological Communicative Disorders Stroke—Alzheimer's Disease Related Association criteria...
The importance of developing unique, neural circuitry-based treatments for the cognitive and neuropsychiatric symptoms Alzheimer disease (AD) was impetus a phase I study deep brain stimulation (DBS) in patients with AD that targeted fornix.To test hypotheses DBS would increase cerebral glucose metabolism cortical hippocampal circuits increased be correlated better clinical outcomes.Open-label trial.Academic medical center.A total 5 mild, probable (1 woman 4 men, mean [SD] age 62.6 [4.2]...
Microglia, the resident immune cells of central nervous system, play an important role in brain's response to injury and neurodegenerative processes. It has been proposed that prolonged microglial activation occurs after single repeated traumatic brain injury, possibly through sports-related concussive subconcussive injuries. Limited vivo imaging studies months years individuals experience a moderate severe suggest widespread persistent activation, but there little study glial cell activity...
Given recent challenges in developing new treatments for Alzheimer dementia (AD), it is vital to explore alternate treatment targets, such as neuromodulation circuit dysfunction. We previously reported an exploratory Phase IIb double-blind trial of deep brain stimulation targeting the fornix (DBS-f) mild AD (the ADvance trial). safety but no clinical benefits DBS-f versus delayed-on (sham) 42 participants after one year. However, secondary post hoc analyses one-year data suggested a possible...
Deep brain stimulation (DBS) to the fornix is an investigational treatment for patients with mild Alzheimer's Disease. Outcomes from randomized clinical trials have shown that cognitive function improved in some but deteriorated others. This could be explained by variance electrode placement leading differential engagement of neural circuits. To investigate this, we performed a post-hoc analysis on multi-center cohort 46 DBS (NCT00658125, NCT01608061). Using normative structural and...
Background Autopsy and in vivo molecular imaging studies suggest altered binding of the α4β2-nicotinic cholinergic receptor (α4β2-nAChR) with cognitive dysfunction Parkinson's disease (PD). Objective To determine relationship between cortical hippocampal α4β2-nAChR [ 18 F]XTRA PET, a high-affinity radiotracer that enables quantification these regions, function individuals PD. Methods Individuals PD (N = 32) age-similar, controls without or dementia 10) completed assessment one 90-min, PET...
Abstract We tested the hypothesis that DYT1 genotype is associated with a disorder of anatomical connectivity involving primarily sensorimotor cortex. used diffusion tensor magnetic resonance imaging (DTI) to assess microstructure white matter pathways in mutation carriers and control subjects. Fractional anisotropy (FA), measure axonal integrity coherence, was reduced ( p < 0.005) subgyral cortex carriers. Abnormal supplementary motor area may contribute susceptibility develop clinical...