A5071455209- Treatment of Major Depression
- Schizophrenia research and treatment
- Bipolar Disorder and Treatment
- Tryptophan and brain disorders
- Mental Health Research Topics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Stress Responses and Cortisol
- Mental Health and Psychiatry
- Functional Brain Connectivity Studies
- Child and Adolescent Psychosocial and Emotional Development
- Neurological disorders and treatments
- Diet and metabolism studies
- Health Systems, Economic Evaluations, Quality of Life
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Psychosomatic Disorders and Their Treatments
- Electroconvulsive Therapy Studies
- Epilepsy research and treatment
- Statistical Methods in Clinical Trials
- Mental Health Treatment and Access
- Suicide and Self-Harm Studies
- Dementia and Cognitive Impairment Research
- Thyroid Disorders and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Autism Spectrum Disorder Research
- Attention Deficit Hyperactivity Disorder
University of Illinois Chicago
2025
Illinois College
2025
Kantar Health (United States)
2024
International Neuromodulation Society
2015-2021
Amsterdam Neuroscience
2018
King's College London
2018
Murphy Oil Corporation (United States)
2018
Massachusetts General Hospital
2008-2015
VA Palo Alto Health Care System
2015
Boston University
2013-2014
In a family study of 1,254 adult relatives patients and controls, lifetime prevalences major affective disorder (including schizoaffective) were 37%, 24%, 25%, 20% 7% in probands with schizoaffective, bipolar I, II, unipolar disease, normal controls. These data compatible the different disorders representing thresholds on continuum underlying multifactorial vulnerability. this model, schizoaffective illness represents greatest vulnerability, followed by I then illnesses. Alcoholism, drug...
• To assess whether computed tomographic findings are present at the onset of schizophrenia, we evaluated CT scans 35 patients with first-episode schizophreniform disorder, 17 chronic 23 affective disorders, 27 other psychiatric and 26 controls. Both schizophrenic had significantly larger cerebral ventricles than did or control subjects. Ventricular size in disorder was not different any groups. Twenty percent enlarged ventricles, (ventricular-brain ratio, > 10). The only subjects outside...
Background: Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional circuits.The safety and efficacy DBS in dementia unknown.Objective: To assess memory circuits as a treatment for patients with mild Alzheimer's disease (AD).Methods: We evaluated active "on" versus sham "off" bilateral directed at fornix-a major fiber bundle brain's circuit-in randomized, double-blind trial (ClinicalTrials.govNCT01608061) 42 AD.We measured cognitive function cerebral glucose metabolism...
Objective: Accumulating evidence indicates that manic symptoms below the threshold for hypomania (mixed features) are common in individuals with major depressive disorder. This form of depression is often severe and associated an increased risk recurrence, suicide attempts, substance abuse, functional disability. study evaluated efficacy safety lurasidone disorder mixed features. Methods: Patients meeting DSM-IV-TR criteria who presented two or three protocol-defined were randomly assigned...
Pregabalin is a novel compound under development for the treatment of several types anxiety disorders. To obtain an initial evaluation efficacy and safety pregabalin in generalized disorder (GAD), we conducted double-blind, fixed-dose, parallel-group, placebo active-controlled multicenter 4-week study that compared 271 patients randomized to receive 50 mg tid (N = 70), 200 66), 67), or lorazepam 2 68), followed by 1-week double-blind taper. The primary parameter was change from baseline...
The low rate of response to antidepressants in treatment resistant depression (TRD) justifies studies next-step therapies following a failure. In TRD clinical trials, it is important verify the accurate diagnosis resistance for all enrolled subjects using reliable and valid instrument. Self-rated scales can reduce impact investigator bias time burden researchers. Massachusetts General Hospital (MGH) Antidepressant Treatment Response Questionnaire (ATRQ) self-rated scale used determine major...
Given recent challenges in developing new treatments for Alzheimer dementia (AD), it is vital to explore alternate treatment targets, such as neuromodulation circuit dysfunction. We previously reported an exploratory Phase IIb double-blind trial of deep brain stimulation targeting the fornix (DBS-f) mild AD (the ADvance trial). safety but no clinical benefits DBS-f versus delayed-on (sham) 42 participants after one year. However, secondary post hoc analyses one-year data suggested a possible...
Targum, S. D. and N. H. Wright (Population Council, Box 2-75, Bangkok, Thailand). Association of the intrauterine device pelvic inflammatory disease: a retrospective pilot study. Am J Epidemiol 100:262–271, 1974.—Using retrospective-case control design, it was found that 48% 50 women with first episode, acute disease were currently wearing an (IUD) compared to 9% 100 controls matched for age, marital status interval since last pregnancy termination. The findings suggest ninefold increased...
Of 49 newly hospitalized patients who met Research Diagnostic Criteria for primary unipolar depression and were given the dexamethasone suppression test (DST), significantly more admitted suicide attempts than nonsuicidal had abnormal DSTs. All five made subsequent (one completed) within 6 months after admission These findings suggest that tendency of endogenously depressed to attempt is exacerbated by an underlying neurobiological disorder reflected limbic-hypothalamic dysregulation...
OBJECT This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety of bilateral deep brain stimulation (DBS) fornix in patients who underwent DBS for treatment mild, probable Alzheimer's disease (AD). METHODS The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled feasibility study being conducted to evaluate safety, efficacy, tolerability with AD. Intraoperative data were collected prospectively. All postoperative MRI....
OBJECTIVE: Few controlled trials of pharmacologic intervention in women with antidepressant-associated sexual dysfunction have been reported, and there is uncertainty about the usefulness putative treatments assessment methodologies. The authors evaluated efficacy buspirone amantadine treatment associated fluoxetine administration. METHOD: Women who had successfully treated for at least 8 weeks reported a deterioration function not present before initiation entered 4-week period. After they...
Eleven patients with Parkinson's disease (PD) and acute psychosis received flexible doses of quetiapine between 25 300 mg/day based on clinical response tolerance. Ten were receiving dopaminergic agents at baseline. Serial efficacy ratings (Brief Psychiatric Rating Scale, Clinical Global Impressions Scale), neuromuscular symptom assessments (Abnormal Involuntary Movement Simpson-Angus Unified Disease Scale [UPDRS]), adverse events monitoring performed for up to 52 weeks. The had moderate...
A newly devised Family Attitudes Questionnaire has been employed to quantify the perceptions of 19 bipolar manic-depressive patients and their well spouses about etiology, familial risk, long-term burden illness, assess abilities marriage childbearing. In this study, 53% compared with 5% (P less than .01) would not have had children if they known more illness prior making these decisions. The overall data suggest that patients, his or her spouse, minimizes denies heritable/familial nature...
The authors administered the thyrotropin-releasing hormone (TRH) stimulation test and dexamethasone suppression (DST) to 54 patients who met DSM-III criteria for major depressive disorder 19 nondepressed patients. A blunted thyrotropin (TSH) response TRH injection was noted in 18 depressed (33%) but no An escape from 23 (43%) only 2 (11%). combined sensitivity of DST identifying 67% with 92% specificity. Only 6 (11%) had abnormal responses both test, suggesting that...