A5000586895- Neurological disorders and treatments
- Advanced MRI Techniques and Applications
- EEG and Brain-Computer Interfaces
- Epilepsy research and treatment
- Neuroscience and Neural Engineering
- Obsessive-Compulsive Spectrum Disorders
- Parkinson's Disease Mechanisms and Treatments
- Advanced Neuroimaging Techniques and Applications
- Glioma Diagnosis and Treatment
- Neural dynamics and brain function
- Botulinum Toxin and Related Neurological Disorders
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Transcranial Magnetic Stimulation Studies
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Genetic Neurodegenerative Diseases
- Cerebrospinal fluid and hydrocephalus
- Autism Spectrum Disorder Research
- Neurology and Historical Studies
- Pharmacological Effects and Toxicity Studies
- Ultrasound and Hyperthermia Applications
- Vascular Malformations Diagnosis and Treatment
- Intracranial Aneurysms: Treatment and Complications
- Neural and Behavioral Psychology Studies
Brigham and Women's Hospital
2016-2025
Harvard University
2015-2025
Circuit Therapeutics (United States)
2023
Massachusetts General Hospital
2002-2023
University of Pittsburgh
2022-2023
Massachusetts Institute of Technology
1999-2023
Harvard University Press
1994-2023
Boston University
2004-2022
Neurological Surgery
1996-2022
Dana-Farber Cancer Institute
2022
Uncontrolled pilot studies have suggested the efficacy of focused ultrasound thalamotomy with magnetic resonance imaging (MRI) guidance for treatment essential tremor.We enrolled patients moderate-to-severe tremor that had not responded to at least two trials medical therapy and randomly assigned them in a 3:1 ratio undergo unilateral or sham procedure. The Clinical Rating Scale Tremor Quality Life Essential Questionnaire were administered baseline 1, 3, 6, 12 months. assessments videotaped...
PURPOSE: To assess the utility of magnetic resonance (MR) cerebral blood volume (CBV) maps in evaluation gliomas. MATERIALS AND METHODS: CBV from 19 patients with histologically proved gliomas were calculated dynamic MR image sets acquired echo-planar spin-echo imaging after intravenous injection gadolinium-based contrast material. RESULTS: The maximum varied 0.82 to 5.40 high-grade group (n = 13) and 1.01 1.21 low-grade 6). difference was statistically significant. Maximum associated...
Abstract The extent of microglial heterogeneity in humans remains a central yet poorly explored question light the development therapies targeting this cell type. Here, we investigate population structure live microglia purified from human cerebral cortex samples obtained at autopsy and during neurosurgical procedures. Using single RNA sequencing, find that some subsets are enriched for disease-related genes signatures. We confirm presence four these subpopulations histologically illustrate...
Atypical meningioma (AM) patients often undergo gross total resection (GTR) at the time of presentation, but subsequent prognosis and optimal management remain unclear. We sought to define long-term recurrence rate AMs after GTR, along with factors predicting recurrence, including postoperative radiation.We performed a retrospective review 108 GTR our institution from 1993 2004. Recurrence risk were analyzed using multivariate Cox regression.There 600 patient-years imaging follow-up on 48...
Functional MRI (fMRI) is of potential value in determining hemisphere dominance for language epileptic patients.To develop and validate an fMRI-based method patients with a wide range potentially operable brain lesions addition to epilepsy.Initially, within-subjects design was used 19 healthy volunteers (11 strongly right-handed, 8 left-handed) determine the relative lateralizing usefulness three different tasks fMRI. An automated, hemispheric analysis laterality analyze whole fMRI data...
OBJECTIVE: Long-term outcome associated with cingulotomy for obsessive-compulsive disorder (OCD) was prospectively assessed. Findings are reported 18 patients previously described in 1995 and 26 new patients. METHOD: An open preoperative follow-up assessment conducted at multiple time points 44 undergoing one or more cingulotomies treatment-refractory OCD. The were assessed by using the Structured Clinical Interview DSM-III-R preoperatively Yale-Brown Obsessive Compulsive Scale, Beck...
Abstract It is believed that the magnetoencephalogram (MEG) localizes an electrical source in brain to within several millimeters and therefore more accurate than electroencephalogram (EEG) localization, reported as 20 mm. To test this belief, localization accuracy of MEG EEG were directly compared. The signal was a dipole at known location brain; made by passing weak current pulse simulating neural through depth electrodes already implanted patients for seizure monitoring. First, MEGs EEGs...
Abstract OBJECTIVE AND IMPORTANCE: Medical treatment of Tourette syndrome is often ineffective or accompanied by debilitating side effects, therefore prompting the need to evaluate surgical therapies. CLINICAL PRESENTATION: We present case a 37-year-old woman with severe since age 10 years. Her symptoms included frequent vocalizations and head arm jerks that resulted in unilateral blindness. Trials more than 40 medications other therapies had failed relieve tics. INTERVENTION: implanted...
Object. Neurosurgical procedures are a viable intervention for severe, treatment-refractory major depression, although they have been associated with only modest rates of efficacy. The purpose this study was to identify possible neuroimaging predictors treatment response anterior cingulotomy in patients depression. Methods. Thirteen underwent stereotactic Symptom severity measured using the Beck Depression Inventory (BDI) both before and approximately 12 months after surgery. authors...
Object The authors prospectively evaluated the safety and efficacy of a novel polyethylene glycol (PEG) hydrogel sealant in patients undergoing elective cranial surgery with documented cerebrospinal fluid (CSF) leakage after sutured dural repair. Methods PEG was used at 11 different study sites 111 intraoperative CSF neurosurgical repair for variety conditions. Intraoperative either spontaneous or induced by Valsalva maneuver. Patients were monitored 3 months postoperatively physical...
Magnetic resonance guided focused ultrasound (MRgFUS) has recently been investigated as a new treatment modality for essential tremor (ET), but the durability of procedure not yet evaluated. This study reports results at 2- year follow-up after MRgFUS thalamotomy ET.A total 76 patients with moderate-to-severe ET, who had responded to least two trials medical therapy, were enrolled in original randomized unilateral and evaluated using clinical rating scale tremor. Sixty-seven continued...
Abstract Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of mechanisms organization. However, increasing clinical electrodes' signal‐to‐noise spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The properties poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those...
Seizures are classically characterized as the expression of hypersynchronous neural activity, yet true degree synchrony in neuronal spiking (action potentials) during human seizures remains a fundamental question. We quantified temporal precision spike ensembles neocortical neurons people with pharmacologically intractable epilepsy. Two seizure types were analyzed: those by sustained gamma (∼40–60 Hz) local field potential (LFP) oscillations or spike-wave complexes (SWCs; ∼3 Hz). Fine...
Obsessive-compulsive disorder (OCD) is a common and disabling psychiatric illness, in significant proportion of patients with OCD the disease refractory to conventional pharmacotherapy psychotherapy. For more than half century, severe, treatment-resistant have been treated stereotactic limbic system lesions, including dorsal anterior cingulotomy. The authors present their results describing efficacy durability surgery for OCD, characterizing large cohort at single institution mean follow-up...
<h3>Objective</h3> To test the hypothesis that transcranial magnetic resonance–guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial. <h3>Methods</h3> Outcomes were based on Clinical Rating Scale Tremor, including hand combined tremor–motor (scale 0–32), functional disability postural 0–4) scores, total...
The objective of this study was to evaluate, at 4 and 5 years posttreatment, the long-term safety efficacy unilateral MRI-guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory essential tremor in a cohort patients from prospective, controlled, multicenter clinical trial.