A5083826270- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neural Engineering
- Neurological disorders and treatments
- Functional Brain Connectivity Studies
- Parkinson's Disease Mechanisms and Treatments
- Neural and Behavioral Psychology Studies
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Neurobiology and Insect Physiology Research
- Neuroendocrine regulation and behavior
- Transcranial Magnetic Stimulation Studies
- Neurobiology of Language and Bilingualism
- Child and Animal Learning Development
- Muscle activation and electromyography studies
- Genetic Neurodegenerative Diseases
- Obsessive-Compulsive Spectrum Disorders
- Neurofibromatosis and Schwannoma Cases
- Action Observation and Synchronization
- Photoreceptor and optogenetics research
- Cultural Differences and Values
- Erythropoietin and Anemia Treatment
- Epilepsy research and treatment
- Botulinum Toxin and Related Neurological Disorders
- Cognitive Science and Education Research
Massachusetts General Hospital
2016-2025
Harvard University
2016-2025
Harvard–MIT Division of Health Sciences and Technology
2015-2025
Harvard University Press
2004-2023
Massachusetts Institute of Technology
2022-2023
Brigham and Women's Hospital
2022-2023
University of Pittsburgh
2022-2023
Royal Brompton Hospital
2023
Case Western Reserve University
2023
Neurological Surgery
2023
Abstract Over the past decade, stereotactically placed electrodes have become gold standard for deep brain recording and stimulation a wide variety of neurological psychiatric diseases. Current electrodes, however, are limited in their spatial resolution ability to record from small populations neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable up 128 channels able at 10 cm tissue. This...
Abstract Humans are capable of generating extraordinarily diverse articulatory movement combinations to produce meaningful speech. This ability orchestrate specific phonetic sequences, and their syllabification inflection over subsecond timescales allows us thousands word sounds is a core component language 1,2 . The fundamental cellular units constructs by which we plan words during speech, however, remain largely unknown. Here, using acute ultrahigh-density Neuropixels recordings sampling...
Abstract OBJECTIVE AND IMPORTANCE: Medical treatment of Tourette syndrome is often ineffective or accompanied by debilitating side effects, therefore prompting the need to evaluate surgical therapies. CLINICAL PRESENTATION: We present case a 37-year-old woman with severe since age 10 years. Her symptoms included frequent vocalizations and head arm jerks that resulted in unilateral blindness. Trials more than 40 medications other therapies had failed relieve tics. INTERVENTION: implanted...
The ability to interact effectively within social groups is essential primate and human behavior. Yet understanding the neural processes that underlie interactive behavior of or by which neurons solve basic problem coding for multiple agents has remained a challenge. By tracking interindividual dynamics three interacting rhesus macaques, we discover detailed representations groups’ in dorsomedial prefrontal cortex, reflecting not only other agents’ identities but also their specific...
Consolidation of memory is believed to involve offline replay neural activity. While amply demonstrated in rodents, evidence for humans, particularly regarding motor memory, less compelling. To determine whether occurs after learning, we sought record from cortex during a novel task and subsequent overnight sleep. A 36-year-old man with tetraplegia secondary cervical spinal cord injury enrolled the ongoing BrainGate brain–computer interface pilot clinical trial had two 96-channel...
<h3>Background and Objectives:</h3> Brain computer interfaces (BCIs) are being developed to restore mobility, communication, functional independence people with paralysis. Though supported by decades of preclinical data, the safety chronically implanted microelectrode array BCIs in humans is unknown. We report results from prospective, open-label, non-randomized BrainGate feasibility study (NCT00912041), largest longest-running clinical trial an BCI. <h3>Methods:</h3> Adults aged 18-75...
Abstract Ketamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by psychotropic side effects. thought to act via NMDA receptors and HCN1 channels produce brain oscillations that are related these Using human intracranial recordings, we found ketamine gamma prefrontal cortex hippocampus, structures previously implicated ketamine’s effects, a 3 Hz oscillation posteromedial cortex, proposed as mechanism for dissociative We...
From sequences of speech sounds
The objective of our study was to investigate the use PET in detection malignant peripheral nerve sheath tumors (MPNSTs) patients with neurofibromatosis type 1 (NF1).Forty-five NF1 who underwent whole-body for suspected MPNST based on clinical symptoms or radiologic examinations were retrospectively evaluated. Ten additional carbon-11 (11C) methionine because equivocal 18F-FDG findings a discrepancy between FDG and findings. images evaluated distribution uptake pattern, standardized values...
Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that often arise from major nerves. Approximately half of MPNSTs in patients with neurofibromatosis Type 1 (NF1) who, comparison without NF1, present at younger ages and larger commonly associated extensive plexiform neurofibromas. These therefore pose a particularly difficult treatment challenge because the morbidity attempted gross-total resection (GTR). Here, authors aim to examine what role extent other covariates...
Real-time brain-machine interfaces (BMI) have focused on either estimating the continuous movement trajectory or target intent. However, natural often incorporates both. Additionally, BMIs can be modeled as a feedback control system in which subject modulates neural activity to move prosthetic device towards desired while receiving real-time sensory of state movement. We develop novel BMI using an optimal design that jointly estimates and monkeys two stages. First, is decoded from spiking...
Measuring connectivity in the human brain involves innumerable approaches using both noninvasive (fMRI, EEG) and invasive (intracranial EEG or iEEG) recording modalities, including use of external probing stimuli, such as direct electrical stimulation. To examine how different measures correlate with one another, we compared 'passive' during resting state conditions to more 'active' single pulse stimulation (SPES). We measured network engagement spread cortico-cortico evoked potential (CCEP)...