A5053027647- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Pain Management
- Treatment of Major Depression
- Anesthesia and Sedative Agents
- Functional Brain Connectivity Studies
- Neonatal and fetal brain pathology
- Sepsis Diagnosis and Treatment
- Hip and Femur Fractures
- Emergency and Acute Care Studies
- Opioid Use Disorder Treatment
- Clinical Reasoning and Diagnostic Skills
- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
- Bee Products Chemical Analysis
- Ocular Surface and Contact Lens
- Enhanced Recovery After Surgery
- Neural dynamics and brain function
- Animal Nutrition and Physiology
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
Massachusetts General Hospital
2021-2024
Harvard University
2022-2024
Beth Israel Deaconess Hospital
2024
Beth Israel Deaconess Medical Center
2023
Opioids administered to treat postsurgical pain are a major contributor the opioid crisis, leading chronic use in considerable proportion of patients. Initiatives promoting opioid-free or opioid-sparing modalities perioperative management have led reduced administration operating room, but this reduction could unforeseen detrimental effects terms postoperative outcomes, as relationship between intraoperative usage and later requirements is not well understood.To characterize association...
Abstract Ketamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by psychotropic side effects. thought to act via NMDA receptors and HCN1 channels produce brain oscillations that are related these Using human intracranial recordings, we found ketamine gamma prefrontal cortex hippocampus, structures previously implicated ketamine’s effects, a 3 Hz oscillation posteromedial cortex, proposed as mechanism for dissociative We...
Abstract Preoperative knowledge of expected postoperative pain can help guide perioperative management and focus interventions on patients with the greatest risk acute pain. However, current methods for predicting require patient clinician input or laborious manual chart review often do not achieve sufficient performance. We use routinely collected electronic health record data from a multicenter dataset 234,274 adult non-cardiac surgical to develop machine learning method which predicts...
Preoperative knowledge of surgical risks can improve perioperative care and patient outcomes. However, assessments requiring clinician examination patients or manual chart review be too burdensome for routine use.
Infants under spinal anesthesia appear to be sedated despite the absence of systemic sedative medications. In this prospective observational study, we investigated electroencephalogram (EEG) infants and hypothesized that would observe EEG features similar those seen during sleep.We computed power spectra spectrograms 34 undergoing infraumbilical surgeries (median age 11.5 weeks postmenstrual age, range 38-65 age). Spectrograms were visually scored for episodes discontinuity or spindle...
With estimated global post-operative mortality rates at 1-4% leading to approximately 3-12 million deaths per year, an urgent need exists for reliable measures of perioperative risk. Existing approaches suffer from poor performance, place a high burden on clinicians gather data, or do not incorporate intraoperative data. Prior work demonstrated that anesthetics induce prefrontal EEG oscillations in the alpha band (8-12Hz) correlate with cognitive outcomes.
Abstract Objective To evaluate the effects of topical application 0.5% tropicamide and 1% atropine on pupil diameter (PD), intraocular pressure (IOP), tear production (TP) in healthy pet rabbits. Animals Studied Ten client‐owned Procedures A prospective, randomized, blinded, crossover study was conducted. Each animal received one drop or a randomly selected eye. PD, IOP, TP were evaluated before drug instillation at 0.25 h, 0.5 0.75 1 2 4 6 8 10 12 24 36 48 60 72 h post‐instillation. Data...
Summary Subanesthetic doses of ketamine produce rapid and sustained anti-depressant effects in patients with treatment-resistant depression. Unfortunately, the usefulness as a treatment is limited by its potential for abuse because psychotropic side such dissociation. Understanding brain dynamics neural circuits involved ketamine’s could lend insight into improved therapies depression fewer adverse effects. It believed that acts via NMDA receptor hyperpolarization-activated cyclic...