A5090343307- Neural dynamics and brain function
- Cardiac, Anesthesia and Surgical Outcomes
- EEG and Brain-Computer Interfaces
- Anesthesia and Sedative Agents
- Functional Brain Connectivity Studies
- Anesthesia and Neurotoxicity Research
- Anesthesia and Pain Management
- Intensive Care Unit Cognitive Disorders
- Veterinary Pharmacology and Anesthesia
- Cephalopods and Marine Biology
- Congenital Heart Disease Studies
- Psychedelics and Drug Studies
- Chemical synthesis and alkaloids
- Mast cells and histamine
- Pain Management and Opioid Use
- Peripheral Nerve Disorders
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pulmonary Hypertension Research and Treatments
- Cardiovascular and Diving-Related Complications
- Pain Management and Placebo Effect
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Treatment of Major Depression
- Sleep and Wakefulness Research
- Body Image and Dysmorphia Studies
Harvard University
2022-2025
Doctors Hospital at Renaissance
2023-2025
Massachusetts General Hospital
2022-2024
Stanford University
2024
University of Pittsburgh
2022-2023
Massachusetts Institute of Technology
2022-2023
Brigham and Women's Hospital
2022-2023
Harvard University Press
2022-2023
Universidad Nacional Autónoma de México
2020
Opioids administered to treat postsurgical pain are a major contributor the opioid crisis, leading chronic use in considerable proportion of patients. Initiatives promoting opioid-free or opioid-sparing modalities perioperative management have led reduced administration operating room, but this reduction could unforeseen detrimental effects terms postoperative outcomes, as relationship between intraoperative usage and later requirements is not well understood.To characterize association...
Abstract Ketamine produces antidepressant effects in patients with treatment-resistant depression, but its usefulness is limited by psychotropic side effects. thought to act via NMDA receptors and HCN1 channels produce brain oscillations that are related these Using human intracranial recordings, we found ketamine gamma prefrontal cortex hippocampus, structures previously implicated ketamine’s effects, a 3 Hz oscillation posteromedial cortex, proposed as mechanism for dissociative We...
Abstract Preoperative knowledge of expected postoperative pain can help guide perioperative management and focus interventions on patients with the greatest risk acute pain. However, current methods for predicting require patient clinician input or laborious manual chart review often do not achieve sufficient performance. We use routinely collected electronic health record data from a multicenter dataset 234,274 adult non-cardiac surgical to develop machine learning method which predicts...
Congenital heart disease (CHD) occurs at increased prevalence high altitude, but there may be a paradoxical later onset of the development Eisenmenger syndrome. We hypothesized that congenital patients altitude are protected from an early irreversible pulmonary hypertension. present ospective observational case series study, supported by PVRI grant, in La Paz, Bolivia, located 3600 m, who underwent surgery for CHD. 10 consecutive aged 5 to 29 years (mean 12) with left-to-right shunts and...
Opioid drugs influence multiple brain circuits in parallel to produce analgesia as well side effects, including respiratory depression. At present, we do not have real-time clinical biomarkers of these effects. Here, describe the results an experiment characterize electroencephalographic signatures fentanyl humans. We find that increasing concentrations induce a frontal theta band (4 8 Hz) signature distinct from slow-delta oscillations related sleep and sedation. also report depression,...
With estimated global post-operative mortality rates at 1-4% leading to approximately 3-12 million deaths per year, an urgent need exists for reliable measures of perioperative risk. Existing approaches suffer from poor performance, place a high burden on clinicians gather data, or do not incorporate intraoperative data. Prior work demonstrated that anesthetics induce prefrontal EEG oscillations in the alpha band (8-12Hz) correlate with cognitive outcomes.
Abstract The neural basis of consciousness remains a major unresolved issue in human neuroscience, with theories and experimental studies differing concerning which brain regions are necessary for consciousness. Direct evidence to resolve this debate requires identifying the global, network, regional involvement during different states humans. We utilized multi-region intracranial single-pulse direct electrical stimulation examine circuit network interactions three canonical consciousness:...
Abstract What happens in the human brain when we are unconscious? Despite substantial work, still unsure which regions involved and how they impacted consciousness is disrupted. Using intracranial recordings direct electrical stimulation, mapped global, network, regional involvement during wake vs. arousable unconsciousness (sleep) non-arousable (propofol-induced general anesthesia). Information integration complex processing were reduced, while variability increased any type of unconscious...
Abstract The neural basis of consciousness remains a major unresolved issue in human neuroscience. To better understand how cortical networks are engaged during different states consciousness, we utilized multi-region intracranial single-pulse direct electrical stimulation to examine circuit and network interactions three canonical consciousness: wake, sleep, under propofol-induced general anesthesia. Increased variability responses, reduced information transfer, complexity characterized...