A5051590702- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Advanced Memory and Neural Computing
- Conducting polymers and applications
- Optical Imaging and Spectroscopy Techniques
- Sleep and related disorders
- Sleep and Wakefulness Research
- Visual perception and processing mechanisms
- Circadian rhythm and melatonin
McGovern Institute for Brain Research
2019-2024
Massachusetts Institute of Technology
2019-2024
Massachusetts General Hospital
2017-2021
Harvard University
2017-2019
The alpha rhythm is the longest-studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology poorly understood. In this study, we used microelectrodes macroelectrodes surgical epilepsy patients measure intracortical thalamic generators of during quiet wakefulness. We first found that both visual somatosensory cortex propagates from higher-order lower-order areas. posterior cortex, anterosuperior areas toward occipital pole, whereas associative...
Abstract Recording neural activity during neurosurgical interventions is an invaluable tool for both improving patient outcomes and advancing our understanding of mechanisms organization. However, increasing clinical electrodes' signal‐to‐noise spatial specificity requires overcoming substantial physical barriers due to the compromised metal electrochemical interface properties. The properties poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) based interfaces surpass those...
The neocortex is composed of six anatomically and physiologically specialized layers. It has been proposed that integration activity across cortical areas mediated by associative connections terminating in superficial layers, slow rhythms. However, the means through which neocortical anatomy physiology interact to coordinate neural remains obscure. Using laminar microelectrode arrays 19 human participants, we found most EEG below 10-Hz (delta/theta) generated layers during both wakefulness...
Despite ongoing advances in our understanding of local single-cellular and network-level activity neuronal populations the human brain, extraordinarily little is known about their "intermediate" microscale circuit dynamics. Here, we utilized ultra-high-density microelectrode arrays a rare opportunity to perform intracranial recordings across multiple cortical areas participants discover three distinct classes that are not locked natural brain rhythmic activity. The first included fast...
Abstract Despite decades of research, we still do not understand how spontaneous human seizures start and spread – especially at the level neuronal microcircuits. In this study, used laminar arrays micro-electrodes to simultaneously record local field potentials multi-unit neural activities across six layers neocortex during focal in humans. We found that, within ictal onset zone, discharges generated a seizure consisted current sinks sources only infra-granular granular layers. Outside...
Abstract The alpha rhythm is the longest studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology poorly understood. In this study, we used micro macro electrodes surgical epilepsy patients measure intracortical thalamic generators of during quiet wakefulness. We first found that posterior cortex propagates from higher-order anterosuperior areas towards occipital pole, consistent with effecting top-down processing. This cortical leads pulvinar...
Abstract Cortical dynamics obey a 1/f power law, exhibiting an exponential decay of spectral with increasing frequency. The slope and offset this reflect the timescale magnitude aperiodic neural activity, respectively. These properties are tightly linked to cellular circuit mechanisms (e.g. excitation:inhibition balance firing rates) as well cognitive processes perception, memory, state). However, physiology underlying law in cortical is not understood. Here, we compared laminar recordings...
The neocortex is composed of six anatomically and physiologically specialized layers. It has been proposed that integration activity across cortical areas mediated by associative connections terminating in superficial layers, slow rhythms. However, the means through which neocortical anatomy physiology interact to coordinate neural remains obscure. Using laminar microelectrode arrays 19 human participants, we found most EEG below 10-Hz (delta/theta) generated layers during both wakefulness...
Human laminar microelectrodes (linear arrays implanted acutely or semi-chronically in surgical patients) present an exciting new frontier of intracranial electrophysiology. Though most iEEG is limited to imaging networks, laminars can resolve the cortical microcircuits underlying cognition. Normally animal models, probes record current-source-density, which reflects transmembrane currents, as well single and multi-unit activity (MUA) throughout depth. These measures neural allow mapping...