A5031558481- Epilepsy research and treatment
- EEG and Brain-Computer Interfaces
- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- Neurological disorders and treatments
- Ocular Oncology and Treatments
- Radiation Therapy and Dosimetry
- Pharmacological Effects and Toxicity Studies
- Boron Compounds in Chemistry
- Head and Neck Cancer Studies
- Nuclear Physics and Applications
- Neuroscience and Music Perception
- Cerebrospinal fluid and hydrocephalus
- Advanced Radiotherapy Techniques
- Memory and Neural Mechanisms
- Advanced MRI Techniques and Applications
- Salivary Gland Tumors Diagnosis and Treatment
- Psychoanalysis and Psychopathology Research
- Blind Source Separation Techniques
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Neurobiology of Language and Bilingualism
- Neuroscience and Neural Engineering
Cleveland Clinic
2016-2025
University of Pittsburgh
2021-2025
Institut de Neurosciences des Systèmes
2013-2024
Inserm
2013-2024
Assistance Publique Hôpitaux de Marseille
2008-2024
Aix-Marseille Université
2011-2024
John Wiley & Sons (United States)
2024
Hudson Institute
2024
UPMC Health System
2022-2023
University of Pittsburgh Medical Center
2021-2023
This paper focuses on high-frequency (gamma band) EEG activity, the most characteristic electrophysiological pattern in focal seizures of human epilepsy. It starts with recent hypotheses about: (i) behaviour inhibitory interneurons hippocampal or neocortical networks generation gamma frequency oscillations; (ii) nonuniform alteration GABAergic inhibition experimental epilepsy (reduced dendritic and increased somatic inhibition); (iii) possible depression GABA(A,fast) circuit activity by...
The identification of brain regions generating seizures ('epileptogenic zone', EZ) in patients with refractory partial epilepsy is crucial prior to surgery. During pre-surgical evaluation, this can be performed from the analysis intracerebral EEG. In particular, presence high-frequency oscillations, often referred as 'rapid discharges', has long been recognized a characteristic electrophysiological pattern EZ. However, date, there no attempt make use specific quantitatively evaluate degree...
Abstract A better understanding of interstructure relationship sustaining drug‐resistant epileptogenic networks is crucial for surgical perspective and to understand the consequences epileptic processes on cognitive functions. We used resting‐state fMRI study basal functional connectivity within temporal lobes in medial lobe epilepsy (MTLE) during interictal period. Two hundred consecutive single‐shot GE‐EPI acquisitions were acquired 37 right‐handed subjects (26 controls, eight patients...
The alpha rhythm is the longest-studied brain oscillation and has been theorized to play a key role in cognition. Still, its physiology poorly understood. In this study, we used microelectrodes macroelectrodes surgical epilepsy patients measure intracortical thalamic generators of during quiet wakefulness. We first found that both visual somatosensory cortex propagates from higher-order lower-order areas. posterior cortex, anterosuperior areas toward occipital pole, whereas associative...
The capacity to evaluate the outcomes of our actions is fundamental for adapting and optimizing behavior depends on an action-monitoring system that assesses ongoing detects errors. neuronal network underlying this executive function, classically attributed rostral cingulate zone, poorly characterized in humans, owing limited number direct neurophysiological data. Using intracerebral recordings, we show leading role played by supplementary motor area (SMA), which rapidly evaluates successful...
Frontal lobe seizures are difficult to characterize according semiologic and electrical features. We wished establish whether different subgroups can be identified these relate anatomic organization.We assessed all from 54 patients with frontal epilepsy that were explored stereoelectroencephalography (SEEG) during presurgical evaluation. Semiologic features concomitant intracerebral EEG changes documented quantified. These variables examined using Principal Component Analysis Cluster...
Defining a bio-electrical marker for the brain area responsible initiating seizure remains an unsolved problem. Fast gamma activity has been identified as most specific onset, but conflicting results have reported. In this study, we describe alternative marker, based on objective description of interictal to ictal transition, with aim identifying time-frequency pattern or 'fingerprint' that can differentiate epileptogenic zone from areas propagation. Seventeen patients who underwent...
Jackson (Brain 1898; 21: 580–90) observed that seizures arising in the medial temporal lobe may result a 'dreamy state', consisting of vivid memory-like hallucinations, and/or sense having previously lived through exactly same situation (déjà vu). Penfield demonstrated dreamy state can sometimes be evoked by electrical stimulation lateral neocortex, especially superior gyrus. Halgren et al. 1978; 101: 83–117) showed hippocampal formation and amygdala Gloor 1990; 113: 1673–94) has suggested...
Very few studies in humans have quantified the effect obtained after direct electrical stimulation of amygdala, terms both emotional and physiological responses. We tested patients with drug-resistant partial epilepsies who were explored intracerebral electrodes setting presurgical evaluation. assessed effects electric stimulations either right or left amygdala on verbally self-reported emotions (Izard scale) psychophysiological markers by recording skin conductance responses (SCRs)...
The localization of the primary auditory cortex in man was studied by direct recordings 150 different sites superior transverse gyrus, especially Heschl's gyms and planum temporale. distribution evoked responses (N13/P17/N26) 15 epileptic patients who were candidates for surgical treatment. Precise topography recording determined stereotactically. Our results provide evidence considering only a restricted portion gyrus (its posteromedial part) as area.
According to most existing literature, the absence of an MRI lesion is generally associated with poorer prognosis in resective epilepsy surgery. Delineation epileptogenic zone (EZ) by intracranial recording usually required but perceived be more difficult 'MRI negative' cases. Most previous studies have used subdural and there relatively less published data on stereoelectroencephalography (SEEG). The objective this study was report experience our group using SEEG presurgical evaluation,...
Low-voltage rapid discharges (or fast EEG ictal activity) constitute a characteristic electrophysiological pattern in focal seizures of human epilepsy. They are characterized by decrease signal voltage with marked increase frequency (typically beyond 25 Hz). have long been observed stereoelectroencephalographic (SEEG) signals recorded intra-cerebral electrodes, generally occurring at seizure onset and simultaneously involving distinct brain regions. Spectral properties as well spatial...