A5037779242- Neurological disorders and treatments
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Transcranial Magnetic Stimulation Studies
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Nerve Injury and Rehabilitation
- Advanced Neuroimaging Techniques and Applications
- Cerebrospinal fluid and hydrocephalus
- Neuroscience and Neural Engineering
- Pain Mechanisms and Treatments
- Glycogen Storage Diseases and Myoclonus
- Ultrasound and Hyperthermia Applications
- Vascular Malformations Diagnosis and Treatment
- Ophthalmology and Eye Disorders
- Pain Management and Treatment
- Stroke Rehabilitation and Recovery
- Pituitary Gland Disorders and Treatments
- Trigeminal Neuralgia and Treatments
- Cerebral Palsy and Movement Disorders
- Lung Cancer Treatments and Mutations
- Intracranial Aneurysms: Treatment and Complications
- Anatomy and Medical Technology
Tokyo Women's Medical University
2015-2024
University of Toronto
2019-2024
Saitama Prefectural Kumagaya Girls High School
2023-2024
Hyogo University
2024
University of Birmingham
1990-2024
University Health Network
2024
Toronto Western Hospital
2024
University College London
2024
Stem Cell Institute
2024
Wellcome/MRC Cambridge Stem Cell Institute
2024
Uncontrolled pilot studies have suggested the efficacy of focused ultrasound thalamotomy with magnetic resonance imaging (MRI) guidance for treatment essential tremor.We enrolled patients moderate-to-severe tremor that had not responded to at least two trials medical therapy and randomly assigned them in a 3:1 ratio undergo unilateral or sham procedure. The Clinical Rating Scale Tremor Quality Life Essential Questionnaire were administered baseline 1, 3, 6, 12 months. assessments videotaped...
<h3>Background</h3> For patients with psychiatric illnesses remaining refractory to 'standard' therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such have previously independently been proposed by various local regional expert groups. <h3>Methods</h3> To expand on these earlier documents, representative members continental international societies, joined efforts further elaborate adopt a pragmatic worldwide set guidelines. These are intended...
Magnetic resonance guided focused ultrasound (MRgFUS) has recently been investigated as a new treatment modality for essential tremor (ET), but the durability of procedure not yet evaluated. This study reports results at 2- year follow-up after MRgFUS thalamotomy ET.A total 76 patients with moderate-to-severe ET, who had responded to least two trials medical therapy, were enrolled in original randomized unilateral and evaluated using clinical rating scale tremor. Sixty-seven continued...
ABSTRACT Background: Magnetic resonance imaging–guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications open stereotactic surgery. Objective: To determine safety profile magnetic unilateral tremor, including frequency, severity adverse events, events. Methods: Analysis data (186 patients, five studies). Results:...
<h3>Objective</h3> To test the hypothesis that transcranial magnetic resonance–guided focused ultrasound (tcMRgFUS) thalamotomy is effective, durable, and safe for patients with medication-refractory essential tremor (ET), we assessed clinical outcomes at 3-year follow-up of a controlled multicenter prospective trial. <h3>Methods</h3> Outcomes were based on Clinical Rating Scale Tremor, including hand combined tremor–motor (scale 0–32), functional disability postural 0–4) scores, total...
Skull density ratio (SDR) assesses the transparency of skull to ultrasound. Magnetic resonance-guided focused ultrasound (MRgFUS) thalamotomy in essential tremor (ET) patients with a lower SDR may be less effective, and risk for complications increased. To address these questions, authors analyzed clinical outcomes MRgFUS based on SDRs.
The objective of this study was to evaluate, at 4 and 5 years posttreatment, the long-term safety efficacy unilateral MRI-guided focused ultrasound (MRgFUS) thalamotomy for medication-refractory essential tremor in a cohort patients from prospective, controlled, multicenter clinical trial.
Introduction: Benign adult familial myoclonus epilepsy (BAFME) is an autosomal dominant disorder characterized by adult-onset cortical tremor and infrequent generalized seizures. Treatment options for managing involuntary movements in BAFME remain limited. Case Presentation: Here, we present two cases involving individuals with who underwent Vim thalamotomy tremor-like myoclonus. Despite the intervention, neither patient experienced any improvement their symptoms. Conclusion: These findings...
The objective of the present study was an evaluation incidence and risk factors for erroneous histopathological diagnosis low-grade glioma after stereotactic biopsy. Twenty-eight tumors diagnosed as biopsy surgically resected thereafter were analyzed. There 13 astrocytomas, 7 oligodendrogliomas, 8 mixed gliomas. All neoplasms had a lobar location. Seven contrast enhancement on MRI. number tissue samples obtained during one in 19 cases, two 4, three or more 5. Complete diagnostic agreement...
Musician's dystonia is a task-specific movement disorder that causes twisting or repetitive abnormal finger postures and movements, which tend to occur only while playing musical instruments. Such will probably lead termination of the careers affected professional musicians. Most currently available treatments have yet provide consistent satisfactory results. We present long-term follow-up results ventro-oral thalamotomy for 15 patients with musician's dystonia.Between October 2003 September...
To report the safety and long-term efficacy of ventro-oral thalamotomy for 171 consecutive patients with task-specific focal hand dystonia.Between October 2003 February 2017, dystonia underwent unilateral thalamotomy. Etiologies included writer's cramps (n = 92), musician's dystonias 58), other occupational task-related 21). The scale was used to evaluate patients' neurologic conditions (range 1-5, high score indicated a better condition). scores before surgery; at 1 week, 3 months, 12...
Abstract Background We report the first case of transcranial magnetic resonance-guided focused ultrasound (MRgFUS) for mesial temporal lobe epilepsy (MTLE). Case presentation The target was located 20 mm lateral from midline and 15 above skull base (left hippocampus). Despite application maximal energy, ablation temperature did not exceed 50 °C, probably because low number effective transducer elements with incident angles below 25 degrees. density ratio 0.56. Post-operative resonance...
Magnetic resonance-guided focused ultrasound thalamotomy (FUS-T) is an emerging treatment for essential tremor (ET).To determine the predictors of outcomes after FUS-T.Two groups were analyzed: 75 ET patients enrolled in pivotal trial, between 2013 and 2015; 114 postpivotal trials, 2015 2016. All had medication-refractory, disabling ET, underwent unilateral FUS-T. The primary outcome (hand score, 32-point scale with higher scores indicating worse tremor) secondary variables (Clinical Rating...
ABSTRACT Background The efficacy of magnetic resonance‐guided focused ultrasound (MRgFUS) thalamotomy for the treatment focal hand dystonia (FHD) is not well known. Objective We aimed to prospectively investigate MRgFUS FHD. Methods performed ventro‐oral (Vo) nucleus in 10 patients with evaluated scores Writer's Cramp Rating Scale (WCRS, 0–30; higher indicating greater severity), Tubiana Musician's Dystonia (TMDS, 0–5; lower and Arm Disability (ADDS, 0%–100%; disability) at baseline 3 12...
✓ Lesch—Nyhan syndrome (LNS) is an X-linked hereditary disorder caused by a deficiency of hypoxanthine-guanine phosphoribosyltransferase. Patients with this are characterized hyperuricemia, self-mutilation, developmental retardation, and movement disorders such as spasticity dystonia. The authors performed bilateral chronic stimulation the globus pallidus internus for control dystonic movements in 19-year-old man LNS. His self-mutilating behavior unexpectedly disappeared after stimulation....
Objective: We have developed an overlaid three-dimensional image (Volu-megraph)-guided navigation system that allows during operative procedures. The is superimposed on the patient''s head and body via a semi-transparent mirror. Volumegraph can display images in air by light beam which based CT/MRI. Method: consists of (thin plate recorded medium), Volumegraphscope original designed triangular-shaped marker for registration. data obtained from CT MRI before operation were processed computer....
Baclofen, an agonist of the γ-aminobutyric acid (GABA) receptor, has antinociceptive effects, and its intrathecal administration reduces allodynic responses in animal models neurogenic central pain. Such experimental studies lead to hypothesis that pain may be induced part by functional abnormalities spinal GABAergic systems. However, whether a system is actually involved human unknown. The authors investigated effect bolus injection baclofen 14 patients with due stroke or cord injury. Nine...
<i>Background:</i> Writer’s cramp is a type of focal dystonia due to dysfunction the pallido-thalamo-cortical circuit. The symptom refractory most conservative treatment, though botulinum toxin injection generally used for symptomatic relief. As surgical treatment dystonia, we performed stereotactic nucleus ventrooralis (Vo) thalamotomy dystonic hand. <i>Methods:</i> Twelve patients (5 men, 3 women; age 26–40 years, mean 32.1 years) with medically intractable...
Cerebellar neuromodulation could influence the pathological abnormalities of movement disorders through several connections between cerebellum and basal ganglia or other cortices. In present report, authors demonstrate effects cerebellar deep brain stimulation (DBS) on a patient with severe generalized fixed dystonia (FD) that was refractory to bilateral pallidotomy intrathecal baclofen therapy. A previously healthy 16-year-old girl presented FD. Bilateral therapy had failed resolve her...
Background: The cerebellum plays an important role in the pathogenesis and pathophysiology of movement disorders, including tremor dystonia. To date, there have been few reports on deep cerebellar stimulation. Case Report: patient was a 35-year-old previously healthy man with no history disorders. He developed stiffness his left hand at age 27 years, which diagnosed as dystonic tremor. We performed right thalamotomy, resulted complete resolution tremor; however, dystonia persisted....