A5000991549- Neurological disorders and treatments
- Obsessive-Compulsive Spectrum Disorders
- Neuroscience and Neural Engineering
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Parkinson's Disease Mechanisms and Treatments
- EEG and Brain-Computer Interfaces
- Autism Spectrum Disorder Research
- Genetic Neurodegenerative Diseases
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Cerebral Palsy and Movement Disorders
- Pain Management and Treatment
- Neuroscience and Neuropharmacology Research
- Muscle activation and electromyography studies
- Virus-based gene therapy research
- Eating Disorders and Behaviors
- Advanced Neuroimaging Techniques and Applications
- Musculoskeletal pain and rehabilitation
- Stroke Rehabilitation and Recovery
- Advanced MRI Techniques and Applications
- Pain Mechanisms and Treatments
- Neuroendocrine regulation and behavior
- Motor Control and Adaptation
- Memory and Neural Mechanisms
KU Leuven
2016-2025
Universitair Ziekenhuis Leuven
2015-2025
VIB-KU Leuven Center for Brain & Disease Research
2021-2023
United Cerebral Palsy
2023
European Academy of Technology and Innovation Assessment
2014
Akadémia Umení v Banskej Bystrici
2007-2013
IMEC
2009-2011
University of Twente
2011
Stereotaxis (United States)
2007-2010
Oldenburger Institut für Informatik
2007-2010
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson9s disease (PD), but its mechanism action unclear. Exaggerated oscillatory synchronization in β (13–30 Hz) frequency band has been associated bradykinesia PD. Accordingly, we tested hypothesis that clinical benefit exerted by STN HFS accompanied suppression local activity. To this end, explored after effects on field potential (LFP) activity recorded from...
Because of the irreversibility lesioning procedures and their possible side effects, we studied efficacy replacing bilateral anterior capsulotomy with chronic electrical capsular stimulation in patients severe, long-standing, treatment-resistant obsessive-compulsive disorder.We stereotactically implanted quadripolar electrodes both limbs internal capsules into six severe disorder. Psychiatrists psychologists performed a double-blind clinical assessment. A blinded random crossover design was...
In 1998, we proposed deep brain stimulation as a last-resort treatment option for patients suffering from severe, treatment-resistant obsessive-compulsive disorder (OCD). Here, 24 OCD were included in long-term follow-up study to evaluate the effects of electrical anterior limbs internal capsule (ALIC) and bed nucleus stria terminalis (BST). We find that ALIC/BST area is safe significantly decreases obsessions, compulsions, associated anxiety depressive symptoms, improves global functioning...
Objective: Investigation of deep brain stimulation (DBS) as a last‐resort treatment alternative to capsulotomy in treatment‐refractory obsessive‐compulsive disorder (OCD). Method: Prospective single‐case based design with evaluation DBS impact on emotions, behaviour, personality traits and executive function three patients OCD. Results: Two experienced sustained improvement OCD symptoms DBS. Yale‐Brown Obsessive‐Compulsive Scale (Y‐BOCS) dropped 12 points 23 baseline Y‐BOCS self‐rating scale...
<h3>Background</h3> For patients with psychiatric illnesses remaining refractory to 'standard' therapies, neurosurgical procedures may be considered. Guidelines for safe and ethical conduct of such have previously independently been proposed by various local regional expert groups. <h3>Methods</h3> To expand on these earlier documents, representative members continental international societies, joined efforts further elaborate adopt a pragmatic worldwide set guidelines. These are intended...
Exaggerated activity in the beta band (13–35 Hz) is a hallmark of basal ganglia signals patients with Parkinson's disease (PD). Beta however not constantly elevated, but comes bursts. In previous work we showed that longer bursts are maintained, more oscillatory synchronisation within subthalamic nucleus (STN) increases, which posited to limit information coding capacity local circuits. Accordingly, higher incidence correlates positively clinical impairment, while opposite true for short,...
<h3>Background</h3> Freezing of gait (FOG) is a debilitating disorder in Parkinson9s disease (PD) with partial responsiveness to dopaminergic medication. To date, notions about the effects subthalamic deep brain stimulation (STN-DBS) on FOG remain controversial. <h3>Objectives</h3> compare bilateral STN-DBS and continued best medical treatment (BMT) occurrence, severity clinical outcomes PD patients at 6 12 months follow-up. <h3>Methods</h3> In this prospective, controlled study, 41 least 5...
Deep brain stimulation—a novel surgical procedure—is emerging as a treatment of last resort for people diagnosed with neuropsychiatric disorders such severe obsessive-compulsive disorder. The US Food and Drug Administration granted so-called humanitarian device exemption to allow patients access this intervention, thereby removing the requirement clinical trial appropriate size statistical power. Bypassing rigors trials puts at risk, limits opportunities scientific discovery, gives...
Lentiviral vectors are promising tools for gene transfer into the central nervous system. We have characterized in detail transduction with human immunodeficiency virus type 1 (HIV-1)-derived encoding enhanced green fluorescent protein (eGFP) adult mouse brain. Different brain regions such as striatum, hippocampus, and lateral ventricle were targeted. The eGFP was transported anterogradely nigrostriatal pathway, but we found no evidence of transport lentiviral vector particle. performance...
Abstract Deep brain stimulation (DBS) has been proposed for severe, chronic, treatment-refractory obsessive-compulsive disorder (OCD) patients. Although serious adverse events can occur, only a few studies report on the safety profile of DBS psychiatric disorders. In prospective, open-label, interventional multi-center study, we examined and efficacy electrical in 30 patients with electrodes bilaterally implanted anterior limb internal capsule. Safety, efficacy, functionality assessments...
Abstract We previously found that electrical stimulation in the anterior limb of internal capsule/bed nucleus stria terminalis (IC/BST) alleviates depressive symptoms severe treatment-resistant obsessive-compulsive disorder (OCD) patients. Here we tested hypothesis either IC/BST or inferior thalamic peduncle (ITP) effectively reduces major (TRD). In a double-blind crossover design, effects at both targets were compared TRD The 17-item Hamilton Depression Rating scale (HAM-D) was primary...
Previous research suggests that anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) modulates NMDA receptor dependent processes mediate synaptic plasticity. Here we test this proposal by applying versus sham tDCS while subjects practiced to flex thumb as fast possible (ballistic movements). Repetitive practice of task has been shown result in performance improvements reflect use-dependent plasticity resulting from mediated, long-term potentiation...